31 results about "Biphenyl derivatives" patented technology

A biphenyl derivative, its preparation method and its use in preparing drugs for treating related diseases, specifically relating to a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

The present application belongs to the field of photoetching technology, and relates to a pentaphenyl derivative, a preparation method thereof and application of the pentaphenyl derivative in photoetching. A photoetching glue composition containing the pentaphenyl derivative can be prepared to obtain a uniform film, the film has good resolution, photosensitivity, adhesion, is easy to store, and the molecular glass as a base component does not precipitate in the film preparation process. The photoetching glue composition prepared by the present application has good film forming property, high thermal stability, is not easy to change in storage, and has low viscosity, and does not need to use an additional solvent for dilution in the use process. After electron beam exposure and development, the exposure pattern has high contrast, excellent resolution and good sensitivity, and can reach a photoetching line width of 40 nm.

A biphenyl derivative having a structure represented by formula I or a pharmaceutically acceptable salt, an ester, an amide, a solvate, an active metabolite, a polymorph, an isotopically labeled substance, an isomer or a prodrug thereof, and a pharmaceutical composition containing the same. The derivative is designed on the basis of a plurality of Wnt upstream kinases with similar structures, and can regulate the pathway by means of at least one Wnt upstream pathway. The derivative increases the expression of reprogramming core genes Oct4, Lin28A and c-Myc when existing independently, and can thus be well applied to cell reprogramming.

The invention relates to a novel method for high-selectivity synthesis of a p-terphenyl derivative through cascade cyclization of dimethyl sulfoxide (DMSO) serving as two C sources and aryl ketone in a multi-component form under the promotion of potassium tert-butoxide. According to the method, only strong base potassium tert-butoxide is used as an accelerant, and complex ligands and expensive metal reagents are prevented from being used. Meanwhile, the formal [1 + 2 + 2 + 1] cascade cyclization reaction is suitable for various substrates, has good tolerance to various substituent groups, and can provide p-terphenyl derivatives which are easy to obtain at a good yield. In addition, the reaction also has the characteristics of low additive price, simple reaction conditions, easily available initial raw materials and the like. According to the method, a multi-group hierarchical cyclization protocol is carried out on starting raw materials which are easy to purchase commercially at lower cost, and the p-terphenyl compounds with multiple substituent groups are synthesized.

This invention discloses a pyrrolobenzene derivative compound, its preparation method, and its pharmaceutical application, belonging to the field of chemical pharmaceutical raw materials and formulation manufacturing technology. The compound has the structure shown. This compound specifically binds to the SGLT-2 protein through a pyrrolobenzene conjugated system, inhibiting its glucose transport function and affecting the IC50 of SGLT-2. 50 Values ​​range from 15 to 105 nM. Suitable for preparing drugs to treat non-alcoholic liver disease, solid tumors, hematological malignancies, and autoimmune diseases, especially effective against abnormal glucose and lipid metabolism in hepatocytes and energy deprivation in tumor cells. The compound possesses enhanced metabolic stability due to its deuterated group and can be formulated into tablets, capsules, injections, and other dosage forms.

The application discloses a biphenyl derivative photoinitiator, a preparation method thereof, a photocuring film material and a preparation method and application thereof. The biphenyl derivative photoinitiator has a structural formula as shown in formula (I), R1 is an electron donor group, and R2 is an electron acceptor group. In the application, the biphenyl is used as a main body structure, different donor groups R1 and acceptor groups R2 are connected, a photoinitiator is synthesized through a Suzuki reaction, and a polymer monomer material is N,N-dimethyl acrylamide (DMA). The photocuring material with long afterglow luminescence can be obtained through a method of ultraviolet light irradiation, under the irradiation of a 365 nm ultraviolet lamp, the initiator absorbs photons to generate active species to attack double bonds in monomers to initiate a polymerization reaction. The photocuring film can produce long afterglow luminescence for several seconds after light irradiation, and can be applied to aspects of anti-counterfeiting, 3D printing and photolithography.

The invention belongs to the technical field of resin gears, and particularly provides a low-friction compound gear as well as a preparation method and application thereof.The low-friction compound gear is prepared by mixing the following raw materials in parts by mass: 50-60 parts of polylaurolactam, 15-20 parts of polyformaldehyde, 2-3 parts of a compatilizer, 2-3 parts of heat conduction fibers, 0.3-0.4 part of a coupling agent, 0.1-0.2 part of a crystal forming agent and 0.01-0.02 part of an antioxidant; the heat-conducting fibers are obtained by etching polyether-ether-ketone fibers and coating and curing the polyether-ether-ketone fibers; the crystal forming agent is obtained by condensation polymerization of p-dichlorobenzene, sodium sulfide and biphenyl derivatives. According to the compound gear prepared by matching the crystal forming agent with the heat-conducting fiber, the crystallinity of the gear product can reach 67.9%, the heat conductivity is greater than or equal to 3.34 W. (m.K)-1, and the mechanical property is excellent.

The invention relates to the technical field of dyes, and discloses a preparation method and application of an environment-friendly acidic color fixing agent, the preparation method comprises the following steps: S1) carrying out sulfonation reaction on tetramethyl biphenyl, acetic anhydride and 98% concentrated sulfuric acid in a first reaction temperature range to obtain a sulfonation product; preparing an intermediate mixture containing a monosulfonic acid biphenyl derivative and a disulfonic acid biphenyl derivative; and S2) dropwise adding deionized water and a 37% formaldehyde solution into the stirred intermediate mixture, heating to a second reaction temperature range, and terminating the condensation reaction when the viscosity is controlled to reach a viscosity threshold range, thereby obtaining the environment-friendly acidic color fixing agent. The prepared acidic color fixing agent does not contain phenol and bisphenol substances, is green and environment-friendly, and can meet the REACH regulation and the limit requirements of OEKO-TEX100. According to the application of the environment-friendly acidic color fixing agent, the color fastness of a nylon fabric or a nylon / spandex fabric can be improved.

A holosymmetric biphenyl derivative and a preparation method therefor and the use thereof are described. Particularly provided are a holosymmetric biphenyl derivative having the structure of formula (I), and a preparation method therefor and a pharmaceutical composition containing same. The series of compounds can be widely used for the preparation of a drug for preventing and / or treating PD-1 / PD-L1 signal pathway-mediated cancers or tumors, immune-related diseases and disorders, communicable diseases, infectious diseases or metabolic diseases, and are expected to be developed into a new generation of PD-1 / PD-L1 inhibitors.

The invention discloses a 1H-triazole biphenyl derivative as well as a preparation method and medical application thereof, and particularly relates to the 1H-triazole biphenyl derivative as shown in a general formula (I) and enantiomers, diastereoisomers, tautomers, N-oxides, solvates, physiologically hydrolyzable esters, preparations and pharmaceutically acceptable salts of the 1H-triazole biphenyl derivative. The invention discloses a 1H-triazole biphenyl derivative having an inhibition effect on S1PR1 and a pharmaceutically acceptable salt thereof, pharmacological experiments prove that the compound has a significant inhibition effect on S1PR1, has an effect of relieving pain, and is expected to become a novel analgesic molecule for replacing opioid drugs. # imgabs0 #

The invention relates to the technical field of organic materials, in particular to a multicolor microcrystalline dielectric material with a sulfur-containing bridge anthraquinone structure and application of the multicolor microcrystalline dielectric material. The material is formed by compounding amyl cyanobiphenyl, heptyl cyanobiphenyl, various cyanobiphenyl derivatives and three sulfur-containing bridge anthraquinone compounds F1, F2 and F3 according to a specific proportion, and the multicolor adjustable characteristic is achieved through the synergistic effect of a p-pi conjugated system constructed by sulfur bridges and auxochrome groups. Meanwhile, due to the introduction of the sulfur bridge, the stability of high temperature resistance and ultraviolet radiation resistance of the material and the compatibility of the material with microcrystalline medium components are remarkably improved. The material can be used for preparing a high-performance dimming functional layer, shows high light transmission contrast ratio, quick response and long-term cycle stability in intelligent windows, vehicle-mounted dimming glass and light-operated display parts, and solves the technical problems of single color and poor environmental tolerance of the existing material.

The present invention is directed biphenyl derivatives, pharmaceutical compositions containing said compounds, and the use of said compounds in the treatment of leukemias, lymphomas and other cancers.

The invention relates to the technical field of chemical synthesis, in particular to a method for oxidative synthesis of benzoxazepine or azepine compounds, which specifically comprises the following steps: taking biphenyl derivatives and sodium benzenesulfinate compounds as reaction raw materials, and electrifying and reacting in an electrolytic tank to obtain dibenzoxazepine derivatives. According to the method, firstly, an additional chemical oxidizing agent is not needed, a traditional chemical oxidation mode is replaced with electrode oxidation, impurities introduced by the chemical oxidizing agent and generated waste salt pollutants are reduced, the method better conforms to the green, economical and environment-friendly concepts, and the environment-friendly treatment cost is reduced;

The invention discloses a synthesis method of a pyridine biphenyl derivative, which comprises the following steps: in a micro-positive pressure nitrogen environment, carrying out coupling reaction on 3-bromo-5-nitropyridine and 4-hydroxy-4 '-nitrobiphenyl in a dehydration solvent; (4) feeding and catalyzing in stages: firstly adding a multifunctional metal chelating agent and a hydrogen catalyst, then adding a sodium dihydrogen phosphate buffering agent and an EDTMPA chelating agent in two stages, and respectively reacting at 0.3-1.1 MPa / 35-45 DEG C and 1.2-1.9 MPa / 55-65 DEG C; and (5) combining ethanol-normal hexane anti-solvent precipitation with gradient cooling crystallization purification to finally obtain the target product with the purity of greater than or equal to 98.95% and the yield of greater than or equal to 94.55%. The method simplifies the synthesis steps, solves the problems of difficult catalyst recovery, many byproducts and high energy consumption in the traditional process, is suitable for industrial mass production, has a wide application range, and obviously improves the vulcanization speed of insoluble sulfur.

The present invention is directed biphenyl derivatives, pharmaceutical compositions containing said compounds, and the use of said compounds in the treatment of leukemias, lymphomas and other cancers.

The present invention relates to a holosymmetric biphenyl derivative, and a preparation method therefor and the use thereof. Particularly, the present invention relates to a holosymmetric biphenyl derivative having the structure of formula (I), and a preparation method therefor and a pharmaceutical composition containing same. The series of compounds of the present invention can be widely used for the preparation of a drug for preventing and / or treating PD-1 / PD-L1 signal pathway-mediated cancers or tumors, immune-related diseases and disorders, communicable diseases, infectious diseases or metabolic diseases, and are expected to be developed into a new generation of PD-1 / PD-L1 inhibitors.

The invention discloses high-temperature-resistant synthetic aromatic hydrocarbon heat-conducting oil and a preparation method thereof. The invention belongs to the technical field of chemical engineering, and the conduction oil used in the invention takes dicyclohexylbenzene and a specific biphenyl derivative as main components, and can effectively transfer heat; meanwhile, the biphenyl derivative is prepared from cyclohexyl biphenyl and methyl biphenyl according to a certain proportion, and the cyclohexyl biphenyl and the methyl biphenyl are mutually matched with dicyclohexylbenzene, so that the heat conduction efficiency of the heat conduction oil is further improved, the heat conduction oil can quickly and uniformly transfer heat in a high-temperature environment, and the requirements of a high-temperature process are met; the high-temperature-resistant heat-conducting coating has excellent heat stability and dispersity, also has good corrosion resistance and heat conducting efficiency, and can meet the use requirements under various high-temperature working conditions.

The present invention relates to an antimicrobial adjuvant containing a biphenyl derivative compound as an active ingredient, and a technology of various uses thereof. The compound of the present invention reduces the dosage of polymyxin antibiotics, which are administered to inhibit the proliferation of gram-negative bacteria, by enhancing the sensitivity of the gram-negative bacteria with respect to the polymyxin antibiotics, is concomitantly administered with the polymyxin antibiotics to show gram-negative bacteria growth inhibitory and killing effects, may notably reduce side effects such as nephrotoxicity, and may prevent or treat sepsis and septic shock due to antibiotic overuse.

The present invention relates to biphenyl derivative inhibitors, their preparation methods, and uses. In particular, the present invention relates to compounds represented by general formula (I), their preparation methods, and pharmaceutical compositions containing the compounds, as well as their use as inhibitors in the treatment of cancer, infectious diseases, and autoimmune diseases, wherein the substituents in general formula (I) have the same definitions as in the specification.

The invention provides an adsorbent for malignant tumors and a preparation method and application thereof.According to the adsorbent, hypercrosslinked macroporous adsorption resin containing chloromethyl serves as a carrier, adsorption ligands are immobilized on the carrier, and the adsorption ligands are polyphenol compounds or biphenyl derivatives; the polyphenol compound or the biphenyl derivative reacts with the chloromethyl group and is immobilized on the carrier. The adsorbent can remove transforming growth factors-beta and programmed death ligands 1 which help tumor metastasis and escape, and can reduce immune escape of malignant tumors, so that the adsorbent can assist in improving the success rate of malignant tumor treatment.

The present invention relates to a novel compound which exhibits an inhibitory effect on the interaction between PD-1 and PD-L1, and a novel biphenyl derivative of the present invention exhibits an excellent cancer prevention and treatment effect by means of the inhibitory effect.

The application belongs to the technical field of resin gears, and specifically provides a low-friction composite gear, a preparation method and application thereof, which is prepared by mixing raw materials including the following components by mass: poly(lauryl lactam) 50-60 parts, polyformaldehyde 15-20 parts, a compatilizer 2-3 parts, a heat-conducting fiber 2-3 parts, a coupling agent 0.3-0.4 parts, a crystallization agent 0.1-0.2 parts, and an antioxidant 0.01-0.02 parts; the heat-conducting fiber is obtained by etching and glue-curing poly(ether ether ketone) fiber; and the crystallization agent is obtained by polycondensation reaction of p-dichlorobenzene, sodium sulfide and a biphenyl derivative. The composite gear prepared by using the crystallization agent and the heat-conducting fiber has a gear product crystallinity of 67.9%, a thermal conductivity of 3.34 W·(m·K) ‑1 , and excellent mechanical properties.

The invention discloses a photo-thermal conversion eutectic material based on a biphenyl derivative and a preparation method thereof, the eutectic material comprises an electron donor and an electron acceptor, the electron donor is a biphenyl derivative containing pyridine nitrogen, the pyridine nitrogen is delocalized from the electron donor to the electron acceptor as an electron source, and the photo-thermal conversion eutectic material is formed. A biphenyl derivative containing pyridine nitrogen is used as an electron donor, when the electron donor is combined with an electron acceptor, electrons of N atoms are delocalized to the electron acceptor from the electron donor to form a charge transfer compound, and the charge transfer compound is self-assembled to form the photo-thermal conversion eutectic material. The eutectic material has excellent photo-thermal conversion performance, the absorption band can reach 200-2000 nm, and light of a wide wave band can be effectively utilized; the high photo-thermal conversion efficiency is achieved, and the photo-thermal conversion efficiency can reach 91.2 + / -6.6% in the near-infrared region of 808 nm; meanwhile, good thermal stability is achieved, and the thermal stability ranges from normal temperature to 155 DEG C.

The invention discloses a pyridine biphenyl derivative as well as a preparation method and application thereof, 3-bromo-5-nitropyridine and 4-hydroxy-4 '-nitrobiphenyl are taken as raw materials, under the action of a solvent and an acid-binding agent, an intermediate product is obtained through condensation reaction, and the intermediate product is reduced under the action of a catalyst and hydrogen to obtain a final product. The product is the pyridine biphenyl derivative, and the method has the advantages of high purity, high yield, few by-products, mild conditions, single solvent and repeated recovery and reuse of the catalyst, is suitable for industrial mass production, and has a wide application range.

This application relates to biphenyl derivatives, wherein the biphenyl derivatives have the structure represented by formula I, or are pharmaceutically acceptable salts, esters, amides, solvates, active metabolites, polymorphs, isotope-labeled, isomers, or prodrugs of the structure represented by formula I. Here, ring A is a methyl- or amino-substituted, or unsubstituted, five-membered ring, and the ring atoms of ring A contain one or two nitrogen atoms, R 1 It is a hydrogen bond donor or acceptor, and its structure contains one or more of the following: an amino group, an imino group, a hydroxyl group, and an ether bond. JPEG2026528760000075.jpg6154

The invention relates to the technical field of room-temperature phosphorescent polymer films, in particular to a room-temperature phosphorescent polymer film with adjustable afterglow color as well as a preparation method and application of the room-temperature phosphorescent polymer film. The preparation raw materials comprise a polymer matrix material solution, a donor material solution and an acceptor material solution. The polymer matrix material solution is obtained by dissolving a polymer matrix material in water; the donor material solution is obtained by dissolving a donor material in an organic solvent; the acceptor material solution is obtained by dissolving an acceptor material in water; the donor material includes a biphenyl derivative. The afterglow color of the obtained room-temperature phosphorescent polymer film can change along with the continuous change of the ratio of the donor material to the acceptor material, and meanwhile, the room-temperature phosphorescent polymer film has ultra-long room-temperature phosphorescent service life and can be applied to an encrypted anti-counterfeiting pattern layer, an ultraviolet light display film or an ultraviolet protective film.

The application is a new method for synthesizing p-terphenyl derivatives by cascade cyclization of aryl ketone multi-component form with dimethyl sulfoxide (DMSO) as two C sources under the promotion of potassium tert-butoxide. The method only uses strong base potassium tert-butoxide as a promoter, avoids the use of complex ligands and expensive metal reagents. At the same time, this formal [1+2+2+1] cascade cyclization reaction is suitable for a variety of substrates, has good tolerance to a variety of substituents, and can provide easily obtained p-terphenyl derivatives with good yield. In addition, the reaction also has the characteristics of low price of additives, simple reaction conditions, easy availability of starting materials, etc. The multi-component cascade cyclization protocol is realized by using easily commercially available starting materials at a lower cost, and a variety of substituted p-terphenyl compounds are synthesized.

The present invention belongs to the technical field of organic electroluminescent materials, and specifically relates to a high-efficiency chiral liquid crystal fluorescent material and its application. The chiral liquid crystal fluorescent material is prepared by using binaphthol as the chiral center, biphenyl derivatives as the liquid crystal primitive, diphenyl sulfone or cyano as the electron acceptor, and aromatic amine derivatives as the electron donor. This type of luminescent material can transition from the triplet state to the singlet state through reverse intersystem crossing to obtain 100% exciton utilization. At the same time, this type of material exhibits obvious liquid crystal properties. Using this type of chiral liquid crystal fluorescent material as the dopant of the luminescent layer, an electroluminescent device is prepared by a solution method, and its maximum external quantum efficiency reaches more than 10%. The present invention discusses in detail the relationship between molecular structure and performance, which is of great significance for constructing a new type of chiral liquid crystal fluorescent material.

The invention provides a pre-lithiation method for a silicon-based negative electrode material of a lithium ion battery. The pre-lithiation method comprises the following steps: (a) dissolving a first biphenyl derivative and a second biphenyl derivative in an organic solvent to form a mixed solution; (b) dissolving a lithium metal in the mixed solution to form a pre-lithiation solvent; and (c) soaking a silicon-based negative electrode material in the pre-lithiation solvent for a predetermined time to obtain a pre-lithiated silicon-based negative electrode material. The invention also provides the silicon-based negative electrode material prepared by the pre-lithiation method, a negative electrode of a lithium ion battery prepared by using the silicon-based negative electrode material, and the lithium ion battery.

The present invention relates to an antibacterial adjuvant containing a biphenyl derivative compound as an active ingredient and various uses thereof. The compound of the present invention reduces the amount of polymyxin antibiotics, and the composition is applied to inhibit the proliferation of gram-negative bacteria, and shows an effect of inhibiting the growth and killing gram-negative bacteria by being used in combination with polymyxin antibiotics to increase the sensitivity of gram-negative bacteria to polymyxin antibiotics, can significantly reduce side effects such as nephrotoxicity, and can prevent or treat septicemia and septic shock caused by overuse of antibiotics.