12 results about "Biphenyl derivatives" patented technology

This invention discloses a pyrrolobenzene derivative compound, its preparation method, and its pharmaceutical application, belonging to the field of chemical pharmaceutical raw materials and formulation manufacturing technology. The compound has the structure shown. This compound specifically binds to the SGLT-2 protein through a pyrrolobenzene conjugated system, inhibiting its glucose transport function and affecting the IC50 of SGLT-2. 50 Values ​​range from 15 to 105 nM. Suitable for preparing drugs to treat non-alcoholic liver disease, solid tumors, hematological malignancies, and autoimmune diseases, especially effective against abnormal glucose and lipid metabolism in hepatocytes and energy deprivation in tumor cells. The compound possesses enhanced metabolic stability due to its deuterated group and can be formulated into tablets, capsules, injections, and other dosage forms.

The application discloses a biphenyl derivative photoinitiator, a preparation method thereof, a photocuring film material and a preparation method and application thereof. The biphenyl derivative photoinitiator has a structural formula as shown in formula (I), R1 is an electron donor group, and R2 is an electron acceptor group. In the application, the biphenyl is used as a main body structure, different donor groups R1 and acceptor groups R2 are connected, a photoinitiator is synthesized through a Suzuki reaction, and a polymer monomer material is N,N-dimethyl acrylamide (DMA). The photocuring material with long afterglow luminescence can be obtained through a method of ultraviolet light irradiation, under the irradiation of a 365 nm ultraviolet lamp, the initiator absorbs photons to generate active species to attack double bonds in monomers to initiate a polymerization reaction. The photocuring film can produce long afterglow luminescence for several seconds after light irradiation, and can be applied to aspects of anti-counterfeiting, 3D printing and photolithography.

The invention relates to the technical field of organic materials, in particular to a multicolor microcrystalline dielectric material with a sulfur-containing bridge anthraquinone structure and application of the multicolor microcrystalline dielectric material. The material is formed by compounding amyl cyanobiphenyl, heptyl cyanobiphenyl, various cyanobiphenyl derivatives and three sulfur-containing bridge anthraquinone compounds F1, F2 and F3 according to a specific proportion, and the multicolor adjustable characteristic is achieved through the synergistic effect of a p-pi conjugated system constructed by sulfur bridges and auxochrome groups. Meanwhile, due to the introduction of the sulfur bridge, the stability of high temperature resistance and ultraviolet radiation resistance of the material and the compatibility of the material with microcrystalline medium components are remarkably improved. The material can be used for preparing a high-performance dimming functional layer, shows high light transmission contrast ratio, quick response and long-term cycle stability in intelligent windows, vehicle-mounted dimming glass and light-operated display parts, and solves the technical problems of single color and poor environmental tolerance of the existing material.

The present invention is directed biphenyl derivatives, pharmaceutical compositions containing said compounds, and the use of said compounds in the treatment of leukemias, lymphomas and other cancers.

The present invention is directed biphenyl derivatives, pharmaceutical compositions containing said compounds, and the use of said compounds in the treatment of leukemias, lymphomas and other cancers.

The present invention relates to an antimicrobial adjuvant containing a biphenyl derivative compound as an active ingredient, and a technology of various uses thereof. The compound of the present invention reduces the dosage of polymyxin antibiotics, which are administered to inhibit the proliferation of gram-negative bacteria, by enhancing the sensitivity of the gram-negative bacteria with respect to the polymyxin antibiotics, is concomitantly administered with the polymyxin antibiotics to show gram-negative bacteria growth inhibitory and killing effects, may notably reduce side effects such as nephrotoxicity, and may prevent or treat sepsis and septic shock due to antibiotic overuse.

The present invention relates to a novel compound which exhibits an inhibitory effect on the interaction between PD-1 and PD-L1, and a novel biphenyl derivative of the present invention exhibits an excellent cancer prevention and treatment effect by means of the inhibitory effect.

The application belongs to the technical field of resin gears, and specifically provides a low-friction composite gear, a preparation method and application thereof, which is prepared by mixing raw materials including the following components by mass: poly(lauryl lactam) 50-60 parts, polyformaldehyde 15-20 parts, a compatilizer 2-3 parts, a heat-conducting fiber 2-3 parts, a coupling agent 0.3-0.4 parts, a crystallization agent 0.1-0.2 parts, and an antioxidant 0.01-0.02 parts; the heat-conducting fiber is obtained by etching and glue-curing poly(ether ether ketone) fiber; and the crystallization agent is obtained by polycondensation reaction of p-dichlorobenzene, sodium sulfide and a biphenyl derivative. The composite gear prepared by using the crystallization agent and the heat-conducting fiber has a gear product crystallinity of 67.9%, a thermal conductivity of 3.34 W·(m·K) ‑1 , and excellent mechanical properties.

The invention relates to the technical field of room-temperature phosphorescent polymer films, in particular to a room-temperature phosphorescent polymer film with adjustable afterglow color as well as a preparation method and application of the room-temperature phosphorescent polymer film. The preparation raw materials comprise a polymer matrix material solution, a donor material solution and an acceptor material solution. The polymer matrix material solution is obtained by dissolving a polymer matrix material in water; the donor material solution is obtained by dissolving a donor material in an organic solvent; the acceptor material solution is obtained by dissolving an acceptor material in water; the donor material includes a biphenyl derivative. The afterglow color of the obtained room-temperature phosphorescent polymer film can change along with the continuous change of the ratio of the donor material to the acceptor material, and meanwhile, the room-temperature phosphorescent polymer film has ultra-long room-temperature phosphorescent service life and can be applied to an encrypted anti-counterfeiting pattern layer, an ultraviolet light display film or an ultraviolet protective film.

The application is a new method for synthesizing p-terphenyl derivatives by cascade cyclization of aryl ketone multi-component form with dimethyl sulfoxide (DMSO) as two C sources under the promotion of potassium tert-butoxide. The method only uses strong base potassium tert-butoxide as a promoter, avoids the use of complex ligands and expensive metal reagents. At the same time, this formal [1+2+2+1] cascade cyclization reaction is suitable for a variety of substrates, has good tolerance to a variety of substituents, and can provide easily obtained p-terphenyl derivatives with good yield. In addition, the reaction also has the characteristics of low price of additives, simple reaction conditions, easy availability of starting materials, etc. The multi-component cascade cyclization protocol is realized by using easily commercially available starting materials at a lower cost, and a variety of substituted p-terphenyl compounds are synthesized.

The invention provides a pre-lithiation method for a silicon-based negative electrode material of a lithium ion battery. The pre-lithiation method comprises the following steps: (a) dissolving a first biphenyl derivative and a second biphenyl derivative in an organic solvent to form a mixed solution; (b) dissolving a lithium metal in the mixed solution to form a pre-lithiation solvent; and (c) soaking a silicon-based negative electrode material in the pre-lithiation solvent for a predetermined time to obtain a pre-lithiated silicon-based negative electrode material. The invention also provides the silicon-based negative electrode material prepared by the pre-lithiation method, a negative electrode of a lithium ion battery prepared by using the silicon-based negative electrode material, and the lithium ion battery.

The present invention suppresses deterioration of detection capability of a vibration sensor that uses liquid crystal.　This vibration sensor comprises: a first substrate and a second substrate disposed to face each other; a first electrode disposed on one surface of the first substrate; a second electrode disposed on one surface of the second substrate; and a liquid crystal layer disposed at least between the first electrode and the second electrode, and having spontaneous polarization. The liquid crystal layer is composed of a liquid crystal material that exhibits a nematic phase or a smectic A phase at room temperature, the liquid crystal material containing one or more types of liquid crystal molecules having a main backbone and first and second side-chain portions respectively located at two ends of the main backbone. In the liquid crystal molecules, the main backbone contains a quaterphenyl derivative, the first side-chain portion contains an alkoxy group having 2 to 5 carbon atoms, the second side-chain portion contains an alkyl group and / or an alkoxy group having 2 to 10 carbon atoms, and the main backbone has one or two fluorine groups.