2 results about "Biphenyl derivatives" patented technology

This invention discloses a pyrrolobenzene derivative compound, its preparation method, and its pharmaceutical application, belonging to the field of chemical pharmaceutical raw materials and formulation manufacturing technology. The compound has the structure shown. This compound specifically binds to the SGLT-2 protein through a pyrrolobenzene conjugated system, inhibiting its glucose transport function and affecting the IC50 of SGLT-2. 50 Values ​​range from 15 to 105 nM. Suitable for preparing drugs to treat non-alcoholic liver disease, solid tumors, hematological malignancies, and autoimmune diseases, especially effective against abnormal glucose and lipid metabolism in hepatocytes and energy deprivation in tumor cells. The compound possesses enhanced metabolic stability due to its deuterated group and can be formulated into tablets, capsules, injections, and other dosage forms.

The application belongs to the technical field of resin gears, and specifically provides a low-friction composite gear, a preparation method and application thereof, which is prepared by mixing raw materials including the following components by mass: poly(lauryl lactam) 50-60 parts, polyformaldehyde 15-20 parts, a compatilizer 2-3 parts, a heat-conducting fiber 2-3 parts, a coupling agent 0.3-0.4 parts, a crystallization agent 0.1-0.2 parts, and an antioxidant 0.01-0.02 parts; the heat-conducting fiber is obtained by etching and glue-curing poly(ether ether ketone) fiber; and the crystallization agent is obtained by polycondensation reaction of p-dichlorobenzene, sodium sulfide and a biphenyl derivative. The composite gear prepared by using the crystallization agent and the heat-conducting fiber has a gear product crystallinity of 67.9%, a thermal conductivity of 3.34 W·(m·K) ‑1 , and excellent mechanical properties.