Biphenyl derivatives

A kind of technology of compound and solvate, applied in the field of new biphenyl derivatives, can solve undisclosed and other problems
CN1759108AActive Publication Date: 2006-04-12THERAVANCE BIOPHARMA R&D IP LLC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THERAVANCE BIOPHARMA R&D IP LLC
Publication Date
2006-04-12

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Abstract

This invention provides biphenyl derivatives of formula I: wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
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Description

Background of the invention

[0001] field of invention

[0002] The present invention relates to novel biphenyl derivatives useful in the treatment of pulmonary diseases. The present invention also relates to pharmaceutical compositions containing such biphenyl derivatives, methods and intermediates for preparing such biphenyl derivatives, and methods of using such biphenyl derivatives for the treatment of pulmonary diseases.

[0003] technical status

[0004] Lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are often treated with bronchodilators. A widely used class of bronchodilators consists of the beta 2 Adrenergic receptor (adrenergic receptor) agonists such as albuterol, formoterol, and salmeterol. These compounds are usually administered by inhalation. Another class of bronchodilators consists of muscarinic receptor antagonists (anticholinergic compounds), such as ipratropium and tiotropium. These compounds are also usually administe...

Claims

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