8 results about "Optical coherence elastography" patented technology

The utility model discloses a kind of non-contact optical coherence elastic imaging endoscope devices, comprising: non-contact ultrasonic excitation and optical detection integrated probe and high-speed sweep frequency laser, the integrated probe includes air-coupled ultrasonic transducer, collimating optical fiber, off-axis parabolic mirror and polymer resin packaging shell, air-coupled ultrasonic transducer diameter is not greater than 2.5 mm, center frequency is not less than 250 kHz, collimating optical fiber is single-mode fiber and emission end integrated collimator is used to produce collimating beam, off-axis parabolic mirror focal length is greater than 7 mm, the polymer resin packaging shell is used to integrally package integrated probe, the polymer resin packaging shell is designed using 3D printing, and it is windowed at the exit end of the off-axis parabolic mirror;The scanning speed of this high-speed sweep frequency laser is 100 kHz, center wavelength 1310 nm, bandwidth 100 nm, synchronous output trigger clock and sampling clock.

The invention discloses a self-adaptive vector strain calculation method and system for three-dimensional optical coherence elastography. The method comprises the following steps: carrying out continuous interference spectrogram acquisition on a material before and after loading through a three-dimensional optical coherence tomography system; preprocessing the acquired continuous interference spectrogram to obtain a three-dimensional structure field pattern before loading and a three-dimensional structure field pattern after loading; performing complex conjugate multiplication on the three-dimensional OCT volume data in the three-dimensional structure field graph before loading voxel by voxel and the three-dimensional OCT volume data in the three-dimensional structure field graph after loading voxel by voxel to obtain a displacement field vector graph before and after material loading; performing adaptive parameter optimization on the displacement field vector diagram to obtain a complex vector after adaptive window averaging; and calculating a three-dimensional strain field based on the complex vector averaged by the adaptive window. In the strain calculation process, the size of the window can be adaptively selected according to the mechanical characteristics of the object, and various mechanical characteristics of the three-dimensional body are fully utilized.

The invention discloses a phase unwrapping algorithm for optical coherence elastography, and relates to the technical field of phase unwrapping. The algorithm is based on an improved U-Net architecture, a network comprising an encoder, a decoder and a jump connection mechanism is constructed, the core is cooperated with an EGA module through a multi-branch Inception residual module in the encoder, the multi-branch Inception residual module extracts different receptive field phase features through five parallel convolution branches, the EGA module calculates gradients through a Sobel operator, attention weights are generated, and the attention weights are calculated through the EGA module. Strengthening phase edge and gradient mutation region response; the decoder removes residual noise through transposition convolution up-sampling, fusion of high and low layer features for fine reconstruction, and optional smoothing filtering. The method solves the problems that a traditional algorithm is low in precision, poor in robustness and low in speed under the scenes of low signal-to-noise ratio, strong speckle disturbance and severe phase gradient change, achieves high precision, high robustness and rapid unwrapping of OCE phase signals, adapts to complex tissue deformation and large-view-field rapid reconstruction requirements, and can be widely applied to the fields of clinical diagnosis, biomedical research and the like.

The application discloses a brain glioma resection device based on machine vision guidance, which comprises an imaging module, a processing module, a decision module and a resection execution module. The imaging module comprises an optical coherence elastography system and an excitation unit, which is used for applying ultrasonic excitation to brain tissue and acquiring elastic response information of the brain tissue under the excitation. The processing module analyzes the elastic response information, constructs the mechanical property distribution of the brain tissue, and identifies the spatial structure boundary between the glioma tissue and the normal brain tissue based on the mechanical property distribution. The decision module generates a resection path and resection parameters according to the structure boundary. The resection execution module resects the target tissue according to the resection path and resection parameters. By combining the tissue mechanical property information acquired by the optical coherence elastography with the resection control, the controllability and consistency of the resection process are improved, and the brain glioma resection can be assisted or automated.

This invention discloses an optical dual-modal imaging device for detecting the boundary of thalamic gliomas, belonging to the field of optical imaging. The device includes an optical coherence elastography (OCE) subsystem and a hyperspectral imaging (HSI) subsystem. The OCE subsystem acquires the mechanical properties and three-dimensional tomographic structural information of the tissue; the HSI subsystem determines the location of the thalamic glioma over a large area and acquires biochemical information. The two subsystems are coupled optically via a dichroic mirror and share a scanning galvanometer and scanning lens to ensure spatial matching of the detection area. A temporal collaborative scanning mode is employed, where the HSI subsystem first performs a large-scale scan to locate the abnormal area, and then the OCE subsystem performs precise elastic and structural imaging of that area. This invention overcomes the limitations of single imaging technologies through dual-modal functional complementarity, achieving high-resolution and accurate detection and imaging of the infiltration boundary of thalamic gliomas.

The invention discloses a brain glioma detection device for mechanical arm assisted light sheet optical coherence elastography, which is characterized in that a millimeter-level air coupling ultrasonic excitation probe and a virtual scanning light sheet probe are jointly integrated to a mechanical arm, and non-destructive and non-contact excitation is performed on brain glioma tissues by utilizing air coupling ultrasound; the scanning light sheet is used for detecting and collecting three-dimensional structure and elasticity modulus information of brain glioma tissues; an integrated mechanical arm is used for clamping an X-ray plate scanning probe to carry out large-range elastic imaging scanning on a suspicious focus area of brain tissue, and mechanical scanning positioning and self-adaptive registration of a three-dimensional structure of the brain tissue are achieved through programming according to irregular morphology characteristics of the brain tissue; according to the system device, use of a coupling agent is avoided, nondestructive, non-contact, high-spatial-resolution and large-view-field-range self-adaptive elastic imaging of the brain glioma boundary is achieved, a doctor can be assisted in tumor excision in an operation, and it is guaranteed that normal brain tissue is not damaged while tumor excision is conducted in the maximum range.

A method for constructing a personalized human eye model. This includes the following steps: (1) simplifying the structural parameters of the human eye to establish a personalized three-dimensional full-eye geometric model; (2) determining the viscoelastic material parameters of the human cornea; (3) using fluid-structure interaction to simulate the actual boundary conditions of the human eye, analyzing the changes in the actual state of the human eye, selecting appropriate element types, discretizing the model into a finite number of aggregates, completing the construction of the finite element human eye model, and solving the model using finite elements; (4) simulating optical coherence elastography of the anterior segment tissues such as the cornea. Considering the individual differences in the geometric morphology and tissue material parameters of the human eye, based on clinical ophthalmological diagnostic data, a personalized full-eye model containing complete geometric morphological information of the human eye was established in finite element software using an elastography method, providing theoretical guidance and technical support for ocular tissue optical coherence elastography equipment.

The invention discloses a bimodal non-contact elasticity detection device based on Brillouin and air-blowing sweep-frequency optical coherence elastography, and relates to the technical field of imaging devices. The Brillouin-sweep-frequency optical coherence elastography common-path scanning unit focuses a Brillouin scattering signal to the surface of a biological tissue sample and focuses a sweep-frequency light beam into the biological tissue sample; the Brillouin scattering elastic imaging system collects backward Brillouin scattering light and carries out frequency discrimination processing so as to determine the longitudinal elastic modulus of the biological tissue sample; the air-blowing non-contact excitation unit is used for applying non-contact air pressure excitation to the surface of the biological tissue sample so as to generate shear wave propagation; the sweep-frequency optical coherence tomography unit is used for acquiring a backscattered light signal and carrying out interference so as to obtain phase change information caused by shear wave propagation in the biological tissue sample; and the time schedule controller is used for performing synchronous control. According to the invention, in-situ synchronous acquisition of bimodal elastic information can be realized, and the measurement consistency and reliability are improved.