A method for measuring corneal elastic modulus in vivo based on jet optical coherence elastography

Abstract

A method for measuring the elastic modulus of the human cornea in vivo based on jet optical coherence elastography technology, using optical coherence elastography (optical coherence elastography, OCE) to collect Doppler images of different cross-sections of in vivo corneal tissue, The elastic wave information in the corneal tissue is extracted through the human eye movement artifact correction algorithm, and the elastic modulus of the corneal tissue is estimated according to the Lamb wave model, which solves the problem that the existing OCE is difficult to achieve in vivo human corneal elastography.

Description

technical field [0001] The invention specifically relates to the technical field of optical coherence elastography, in particular to a method for measuring the elastic modulus of human cornea in vivo based on jet optical coherence elastography technology. Background technique [0002] Corneal tissue is a viscoelastic material with both viscous and elastic properties, which can be characterized by biomechanical parameters such as elastic modulus and viscosity coefficient. Existing studies have found that corneal mechanical properties can assist in the early diagnosis of certain ophthalmic diseases (such as keratoconus, Fuchs corneal degeneration, etc.) and guide corneal-related operations (such as corneal refractive surgery, corneal cross-linking surgery, etc.). [0003] Optical Coherence Elastography (OCE) is based on Optical Coherence Tomography (OCT), which uses biomechanical parameters such as elastic modulus, shear modulus, and viscosity coefficient of soft tissue as ima...

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Problems solved by technology

Air-coupled ultrasonic radiation force induces very small deformation of corneal tissue, which is not easy to cause overall eye movement, while micro-air pulse excitation can cause large corneal deformation accompanied by overall eye movement; in addition, the research objects were rabbits after anesthesia , the algorithm only considers the interference of eyeball axial movement artifacts, but in fact, clinical subjects have the interference of eyeball horizontal movement artifacts, so it is still not possible to directly apply the algorithm to clinical practice

[0010] Due to the lack of human eye movement artifact correction algorithm for jet OCE in the prior art, the elastic modulus of human corneal tissue in vivo has not yet been obtained

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