Brillouin scattering and optical coherent elastic imaging in-situ detection method

Abstract

The invention provides a Brillouin scattering and optical coherent elastic imaging in-situ detection method. According to the method, a wavelength division multiplexing method and a confocal optical path are adopted to integrate a Brillouin scattering elastic imaging system and an optical coherent elastic imaging system, then the two detection systems can perform imaging detection without mutual influences through a time sequence control system of a computer, and therefore in-situ detection of a bulk elasticity modulus and a shear elasticity modulus of a sample can be completed under the condition of not moving the sample. The method has the advantages that comparative research of the two elasticity moduli can provide technical support for diagnosis and early prevention of numerous clinical diseases; and the method has important significance and value for diagnosis, treatment and prevention of multiple clinical diseases currently and especially multiple eye diseases.

Description

technical field [0001] The invention relates to an imaging detection method of elastic modulus of biological tissue, in particular to a method capable of realizing in-situ detection of Brillouin scattering and optical coherence elastic imaging. Background technique [0002] At present, Brillouin scattering elastography and optical coherence elastography are the latest methods to detect the elastic properties of biological tissue. The physical principles of the two are different, and the bulk elastic modulus and shear elastic modulus of biological tissue can be obtained respectively. This is important for some clinical The diagnosis and treatment of diseases, especially eye diseases (myopia, keratoconus, etc.) are of great significance. But there are still some technical limitations in the research on Brillouin scattering elastography and optical coherence elastography. [0003] In clinical practice, some chronic diseases, especially ophthalmological myopia, presbyopia or ca...

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Problems solved by technology

But there are still some technical limitations in the research on Brillouin scattering elastography and optical coherence elastography

[0003] In clinical practice, some chronic diseases, especially ophthalmological myopia, presbyopia or cataract, often cannot be directly judged in the early stage whether the disease occurs, and the elastic detection method can be used to detect whether the nature of the tissue has occurred from a biomechanical point of view. Pathological changes, so the means of elastic detection is needed to obtain the elastic properties of the tissue, but other technical means cannot achieve such high precision as optical means, and the use of optical means is a non-destructive means

The reason for the comparison is that the shear elastic modulus and the bulk elastic modulus are the classical physical quantities that we consider to characterize the elastic properties of the sample, but because the magnitudes of the two elastic moduli are usually much different, it is impossible to use the same system to do Therefore, our patent can achieve this problem. The advantage of this is that we can analyze how the elasticity of the tissue changes from the two moduli, or we can determine which of the two elastic moduli is more suitable for use. Clinically, the detection of elastic properties of biological tissues is very different. At present, there is no technical means that can realize the detection of two elastic moduli at the same time, let alone the comparative study of the two elastic moduli.

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