Microneedle transdermal drug delivery device
The microneedle drug delivery device with a spiral connection and needle adjustment mechanism solves the problems of poor drug dosage control and insufficient drug delivery in existing equipment, achieves precise drug delivery and deep penetration into scar tissue, and improves the user experience.
Patent Information
- Application Number
- CN202510875693.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-27
- Publication Date
- 2025-09-05
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Existing microneedle drug delivery devices cannot effectively control the dosage of drugs and the drug delivery is insufficient, causing pain and inconvenience.
The spirally connected microneedle body is coordinated with the base, combined with the needle body adjustment mechanism and the drug pump. The dosage is adjusted through the electronic display screen, and is equipped with a liquid level sensor and a rotating sealing ring to achieve precise control and deep drug delivery.
It achieves precise control of drug dosage and deeper drug delivery, reduces pain, and improves patient compliance and drug delivery adequacy.
Smart Images
Figure FT_1
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of transdermal drug delivery equipment, in particular to a microneedle transdermal drug delivery device. Background Art
[0002] The therapeutic effect of a drug depends not only on the drug itself, but also on the drug delivery system, which has a crucial impact on its efficacy. For biomacromolecules such as peptides, proteins, DNA, and vaccines, represented by insulin, oral bioavailability is very low due to degradation by gastrointestinal enzymes and the first-pass effect in the liver, thus failing to achieve therapeutic effects. Subcutaneous injection allows for the convenient and rapid delivery of large doses of drugs into the human body and can compensate for the shortcomings of oral administration. However, its limitations include significant pain during administration, injection site damage, the need for specialized techniques, and the difficulty in achieving sustained administration. Patients, especially children, often have a fear of needles, making long-term administration unsuitable. Transdermal drug delivery systems, also known as transdermal therapeutic systems, are preparations in which drugs are absorbed through the skin via capillaries at a certain rate into the systemic circulation to produce their effects. Compared with traditional drug delivery methods, transdermal drug delivery has many advantages: it can produce sustained, constant, and controllable blood drug concentrations, significantly enhancing the activity of drugs with short half-lives due to rapid metabolism in the body, avoiding the first-pass effect of the liver and interference from gastrointestinal factors, and minimizing toxic side effects. It is painless, non-invasive, or minimally invasive, allows patients to self-administer medication, is convenient to use, allows for discontinuation of drug delivery at any time, and has high patient compliance, making it one of the fastest-growing new dosage forms. Existing transdermal drug delivery devices suffer from issues such as an inability to effectively control drug dosage and insufficient drug delivery. Summary of the Invention
[0003] The object of the present invention is to provide a microneedle transdermal drug delivery device to solve the problems mentioned in the above background art, such as the inability of existing microneedle drug delivery devices to effectively control the drug dosage and insufficient drug delivery.
[0004] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a microneedle transdermal drug delivery device, comprising a base and a microneedle body, the microneedle body being conical, the microneedle body comprising a needle body and a needle tip, a hollow needle tube being arranged in the needle tip, the needle body being threadedly matched with the base, a needle body adjustment mechanism being arranged in the base, the end of the drug delivery tube being inserted into the needle body, one end of the drug delivery tube being connected to the needle body, and the other end opening passing through the middle of the base, a thread groove being arranged on the base outside the opening of the drug delivery tube for matching with the thread of the medicine bottle, a drug pump being arranged in the drug delivery tube, and a liquid level sensor being arranged at the base between the drug delivery tube and the thread groove.
[0005] The inner wall and the outer wall of the thread groove are both provided with threads matching with the mouth of the medicine bottle.
[0006] The power supply of the medicine pump is set as a lithium battery, which is embedded in the base.
[0007] The outer wall of the root of the needle body is provided with an external thread which is threadably matched with the threaded hole in the middle of the base.
[0008] The end of the drug delivery tube extending into the inner cavity of the needle body is provided with a rotary sealing ring.
[0009] The needle body adjusting mechanism comprises a gear ring fixed on the outside of the root of the needle body and a gear shaft matched with the gear ring.
[0010] A groove is provided on the outside of the base, and the gear shaft is rotatably installed through the rotating shaft and the groove.
[0011] Compared with the prior art, the present invention has the following beneficial effects: The microneedle connection of the present invention uses a spiral connection, which is convenient for replacement and the use of hollow disposable microneedles, and better controls the amount of medicine and allows deeper administration. The needle body can penetrate the medicine deeper and more effectively into the scar tissue. The electronic display screen can be used to adjust and select the dosage by controlling the medicine pump. The electronic display screen can help users accurately grasp the dosage. BRIEF DESCRIPTION OF THE DRAWINGS
[0012] Figure 1 This is a structural diagram of the microneedle transdermal drug delivery device provided by the present invention.
[0013] In the above drawings, substrate 1, microneedle body 2, needle body 2-1, needle tip 2-2, hollow needle tube 2-3, threaded hole 3, needle body adjustment mechanism 4, gear ring 4-1, gear shaft 4-2, drug delivery tube 5, threaded groove 6, drug pump 7, liquid level sensor 8, power supply 9, rotating sealing ring 10, groove 11, rotating shaft 12, electronic display screen 13. DETAILED DESCRIPTION
[0014] The technical solutions in the embodiments of the present invention will be described clearly and completely below with reference to the accompanying drawings in the embodiments of the present invention.
[0015] like Figure 1As shown, a microneedle transdermal drug delivery device includes a substrate 1 and a microneedle body 2, the microneedle body 2 is tapered, the microneedle body 2 includes a needle body 2-1 and a needle tip 2-2, a hollow needle tube 2-3 is provided in the needle tip 2-2, the needle body 2-1 is threadedly matched with the substrate 1, specifically, the outer wall of the root of the needle body 2-1 is provided with an external thread that is threadedly matched with the threaded hole 3 in the middle of the base, and the length of the needle body 2-1 extending out of the substrate 1 can be controlled by rotating the needle body 2-1, thereby controlling the drug delivery depth of the needle body 2-1, and a needle body adjustment mechanism 4 is provided in the substrate 1. The structure 4 drives the needle body 2-1 to rotate, and the end of the dosing tube 5 is inserted into the needle body 2-1. One end of the dosing tube 5 is connected to the needle body 2-1, and the other end opens through the middle of the base 1. A threaded groove 6 that cooperates with the thread of the medicine bottle is provided on the base 1 outside the opening of the dosing tube 5. A medicine pump 7 is provided in the dosing tube 5. The base is installed by cooperating with the thread of the medicine bottle through the threaded groove 6. The dosing tube 5 is inserted into the medicine bottle, and the medicine pump 7 is started to draw the medicine in the medicine bottle into the needle body 2-1 for injection. A liquid level sensor 8 is provided at the base 1 between the dosing tube 5 and the threaded groove 6 to detect the remaining amount of medicine in the medicine bottle.
[0016] The inner wall and the outer wall of the thread groove 6 are both provided with threads that match the mouth of the medicine bottle. The mouth of the medicine bottle is sealed by the double thread matching, which plays a role in installation connection and prevents drug contamination.
[0017] The power supply 9 of the medicine pump 7 is configured as a lithium battery, which is embedded in the base. The medicine pump 7 is powered by the power supply 9 .
[0018] The end of the dosing tube 5 extending into the inner cavity of the needle body 2-1 is provided with a rotating sealing ring 10, so that the dosing tube 5 is connected to the needle body 2-1 and prevents the drug from leaking, and the needle body 2-1 can rotate relative to the dosing tube 5 or slide axially.
[0019] The needle body adjustment mechanism 4 includes a gear ring 4-1 fixed to the outside of the root of the needle body 2-1 and a gear shaft 4-2 matched with the gear ring 4-1. The needle body 2-1 and the gear ring 4-1 are detachable in a snap-on manner to facilitate the replacement of the disposable hollow needle tube 2-3. A groove 11 is provided on the outside of the base, and the gear shaft 4-2 is rotatably installed with the groove 11 through the rotating shaft 12. By rotating the gear shaft 4-2, the needle body 2-1 fixedly connected to the gear ring 4-1 is driven to rotate through the cooperation of the gear shaft 4-2 and the gear ring 4-1, thereby adjusting the length of the needle body 2-1 extending out of the base 1. When administering the drug, the part of the needle body 2-1 extending out of the base 1 is completely pushed into the skin, and the length of the needle body 2-1 extending out of the base 1 is controlled so that the drug can penetrate deeper and more effectively into the scar tissue. The length of the gear shaft 4-2 is controlled and set reasonably so that the gear ring 4-1 on the needle body 2-1 is always matched with the gear shaft 4-2 during the movement.
[0020] An electronic display screen 13 is provided on the outside of the base 1. The electronic display screen 13 can adjust and select the dosage of the drug by controlling the drug pump 7. The electronic display screen 13 can facilitate the user to accurately grasp the dosage of the drug. The microneedle connection also uses a spiral connection, which is convenient for replacement and facilitates the use of hollow disposable microneedles. The needle body 2-1 can penetrate the drug deeper and more effectively into the scar tissue.
Claims
1. A microneedle transdermal drug delivery device, characterized in that: It includes a base and a microneedle body. The microneedle body is conical. The microneedle body includes a needle body and a needle tip. A hollow needle tube is provided in the needle tip. The needle body cooperates with the base thread. A needle body adjustment mechanism is provided in the base. The end of the dosing tube is inserted into the needle body. One end of the dosing tube is connected to the needle body, and the other end opens through the middle of the base. A threaded groove that cooperates with the thread of the medicine bottle is provided on the base outside the opening of the dosing tube. A medicine pump is provided in the dosing tube. A liquid level sensor is provided at the base between the dosing tube and the threaded groove.
2. A microneedle transdermal drug delivery device according to claim 1, characterized in that: The inner wall and the outer wall of the thread groove are both provided with threads matching with the mouth of the medicine bottle.
3. The microneedle transdermal drug delivery device according to claim 1, characterized in that: The power supply of the medicine pump is set as a lithium battery, which is embedded in the base.
4. The microneedle transdermal drug delivery device according to claim 1, characterized in that: The outer wall of the root of the needle body is provided with an external thread which is threadably matched with the threaded hole in the middle of the base.
5. The microneedle transdermal drug delivery device according to claim 1, characterized in that: The end of the drug delivery tube extending into the inner cavity of the needle body is provided with a rotary sealing ring.
6. The microneedle transdermal drug delivery device according to claim 1, characterized in that: The needle body adjusting mechanism comprises a gear ring fixed on the outside of the root of the needle body and a gear shaft matched with the gear ring.
7. The microneedle transdermal drug delivery device according to claim 1, characterized in that: A groove is provided on the outside of the base, and the gear shaft is rotatably installed through the rotating shaft and the groove.