Application of hexachlorophene in preparation of voltage-gated potassium channel agonist

A technology of agonist and hexachlorophene, applied in the field of application in the preparation of antiarrhythmic drugs and antiepileptic drugs
CN103565783AActive Publication Date: 2014-02-12SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Publication Date
2014-02-12

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Abstract

The invention provides an application of hexachlorophene in the preparation of a KCNQ agonist. In addition, the invention provides an application of the hexachlorophene in the preparation of a medicine serving as the KCNQ agonist. In the application, the KCNQ agonist can be a KCNQ1 agonist, a KCNQ1 / KCNE1 agonist, a KCNQ2 agonist or KCNQ2 / KCNQ3 agonist. The hexachlorophene has the effects of shortening the action potential duration and treating the arrhythmia by boosting KCNQ1 / KCNE1 electric currents and promoting the repolarization of the action potential of myocardial cells. The subtype potentiation proves that the hexachlorophene is capable of enhancing KCNQ and M electric currents and has the effects of adjusting the membrane potential level by boosting KCNQ2 electric currents and KCNQ2 / KCNQ3 hetero-oligomer electric currents and weakening the issuing frequency of the action potential; the application of the hexachlorophene in the preparation of medicines taking KCNQ as anti-epileptic targets is realized, and the anti-epileptic effect is achieved.
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Description

technical field

[0001] The present invention belongs to the field of medicines. Specifically, the present invention relates to the application of hexachlorophene in the preparation of KCNQ agonists, wherein, in the above application, the KCNQ agonists can be KCNQ1 agonists, KCNQ1 / KCNE1 agonists, KCNQ2 agonists agent or KCNQ2 / KCNQ3 agonist. In addition, the present invention also provides an application of hexachlorophene in the preparation of a medicine as a KCNQ agonist, wherein, in the above application, the KCNQ agonist can be a KCNQ1 agonist, a KCNQ1 / KCNE1 agonist, a KCNQ2 agonist agent or KCNQ2 / KCNQ3 agonist. In addition, the present invention also relates to the application of hexachlorophene in the preparation of antiarrhythmic drugs and antiepileptic drugs. Background technique

[0002] Hexachlorophene (HCP), also known as mycofenol, is widely used as a local anti-inflammatory and bactericidal drug in clinical practice. Full chemical name: 2,2'-methylenebis(3,4,6-...

Claims

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