Device for enhancing medicine curative effect by amplitude modulation electric field

Abstract

The invention relates to a device for enhancing the medicine curative effect by an amplitude modulation electric field. The device comprises a power supply, a central control unit, a frequency modulation signal generating unit, an amplitude modulation unit, a power amplification unit, an output distribution unit, an insulation electrode and an insulation electrode positioning system, wherein under the control of the central control unit, the frequency modulation signal generating unit generates a required frequency signal; the required frequency signal is modulated by the amplitude modulation unit to generate a square wave form amplitude modulation signal; the square wave from amplitude modulation signal is amplified by the power amplification unit and is then allocated onto one than one pair of insulation electrodes by the output distribution unit, so that an amplitude modulation electric field with the continuous weakness serious sudden change is generated between more than one pair of insulation electrodes. The amplitude modulation electric field with the continuous weakness serious sudden change is applied onto cells; cell membrane generates depolarization and repolarization, so that the membrane permeability reversibility is improved; the quantity of the medicine passing through the cell membranes is increased; the curative effect is enhanced.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and relates to a device for enhancing the curative effect of medicine by using an amplitude-modulated electric field. Background technique [0002] Since 1980, electric fields have been widely used in the fields of biology and medicine, including killing microorganisms, cell fusion, gene transformation and tumor treatment. In 1987, Japanese scholar Okino pioneered electric pulse chemotherapy (EPCT). EPCT is a tumor treatment method that combines electric pulses with electric field strengths as high as kilovolts per centimeter and durations of microseconds or even nanoseconds with chemical drugs. This method only Only a small dose of drugs can kill tumor cells efficiently and with low toxicity, greatly improving the efficacy of chemotherapy drugs and reducing their toxic and side effects. [0003] Electric field therapy can be used in combination with chemotherapy for maintenance therapy ...

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a device that uses amplitude-modulated electric field to enhance the curative effect of drugs. One is to overcome the unsafe use of high voltage in pulse therapy, the invasiveness of direct insertion of insulated electrodes into the body, the pH value of the extracellular fluid in the electrode action area, etc. The shortcoming of damaging normal tissues due to drastic changes; the second is to generate an amplitude-modulated electric field with continuous and sharp changes in electric field strength between a pair of insulated electrodes, which is used to enhance the drug treatment, and can significantly reduce the drug consumption while ensuring the same curative effect of the drug To reduce the toxic and side effects of the drug, the curative effect of the drug is significantly enhanced due to the increase in the amount of the drug permeating the cell membrane at the same dosage

Images