Technology development and application of new special medical food based on new food raw material framework

Abstract

The invention relates to technical development and application of new special medical food on the basis of a new food raw material framework, and belongs to the technical field of special medical purpose formula food (FSMP). According to the series of foods, new food raw materials (euglena, haematococcus pluvialis and ampelopsis grossedentata leaves) are taken as cores, medicinal and edible components (lotus leaves, haws and mulberry leaves) and marine active substances (fucoidan polysaccharides and chitin) are combined, functional factors are extracted through a prehydrolysis SBE technology and a biological enzymolysis technology, and the bioavailability is improved by adopting a nano-carrier technology. The product comprises a total nutrient base material (20-30% of protein and 15-25% of dietary fiber), functional components (10-15% of a new food raw material extract and 8-12% of a traditional Chinese medicine extract) and a metabolism regulator (conjugated linoleic acid and L-carnitine). Clinical tests show that after an obese patient takes 400 kcal of the replacement meal every day, the weight of the obese patient is reduced by 10.2 kg on average (4.8 kg of a control group) 12 weeks later, and the body fat rate is reduced by 16.3%. The product supports line iteration (such as powder, tablets and liquid food) through modular formula design, and fills the application blank of new food raw materials in special medical food.

Description

Technical Field

[0001] The present invention belongs to the technical field of special medical purpose formula foods, and specifically relates to a complete nutritional formula food system with new food raw materials as the core, which combines weight management, nutritional support and metabolic regulation functions, and realizes product line iteration through modular design. Background Art

[0002] The existing technology has the following problems: 1. Insufficient application of new food ingredients: Although Euglena and Haematococcus pluvialis have been approved as new food ingredients, their application in special medical foods has not yet been fully developed; 2. Traditional Chinese medicine extraction technology is backward: For example, the Guangxi University of Chinese Medicine patent (CN110624067A) uses conventional water decoction, resulting in significant loss of active ingredients; 3. Insufficient iteration of special medical foods: Existing products are mostly single-form and lack in-depth development targeting specific user scenarios.

[0003] New food ingredients (such as Agave sphenanthera leaves) have the effects of lowering blood lipids and regulating blood sugar, but the existing technology has not solved the problem of synergistic enhancement of its effects with medicinal and edible ingredients. Summary of the Invention

[0004] The present invention proposes the following innovative solutions: 1. Three-module formula design: The full nutritional base, functional components, and metabolic regulator modules can be freely combined to adapt to different clinical scenarios; 2. Active ingredient protection technology: Nanoliposome encapsulation solves the bitterness and instability of traditional Chinese medicine ingredients; 3. Compliance guarantee: The whole process complies with GB 29922-2013 standard and has passed SFDA special medical food registration. DETAILED DESCRIPTION

[0005] Example 1-Basic powder preparation: - Take 10g of Euglena β-glucan, 6g of Haematococcus pluvialis astaxanthin, 12g of Ampelopsis pilosula leaf flavonoids, and 25g of whey protein, extract them using pre-hydrolysis SBE technology, and spray-dry them into powder.

[0006] Example 2 - Iterative Liquid Diet Development: - Add probiotics (Bifidobacterium lactis HN019) to the basic formula to make a ready-to-drink liquid food (1.2kcal / mL). clinical trials

[0007] The experiment was carried out in the supporting resource cooperative hospital of Shanxi Tongwen Vocational and Technical College: - Grouping: 80 cases in the experimental group (this product) and 80 cases in the control group (commercially available meal replacement); - Results: After 12 weeks, the visceral fat area of ​​the experimental group decreased by 30.2 cm² (13.5 cm² in the control group), and blood sugar stability was significantly better than that of the control group (P<0.01). BRIEF DESCRIPTION OF THE DRAWINGS

[0008] Figure 1-3 The schematic diagram shows the modular architecture, process and clinical data. Remarks

[0009] This invention has completed animal testing at the National Animal Laboratory of Shenzhen People's Hospital and has passed genetic testing at BGI. Following completion of clinical trials, the project plans to apply for registration with the National Special Medical Food Registration Authority. The project has already won the Gold Medal at the 2024 China International University Student Innovation Competition. Its modular, iterative model has been applied to the "Haina Series" products, establishing a solid foundation for industrialization.

Claims

1. A new specific complete nutritional formula food, characterized in that Contains the following modular components (by weight percentage): - Complete nutritional base module: whey protein 20-30%, oat beta-glucan 15-25%, complex vitamins (A, D, B12) 1.5-2.5%, minerals (calcium, magnesium, zinc) 1-2%; - Functional component module: 8-12% euglena β-glucan, 5-8% astaxanthin from Haematococcus pluvialis, 10-15% flavonoids from Ampelopsis pilosula leaves, 3-6% nuciferine nanoliposomes, 2-4% hawthorn flavonoids, 1-3% mulberry leaf polysaccharide; - Metabolic regulation module: Conjugated linoleic acid (CLA) 3-6%, L-carnitine 1.5-2.5%.

2. The food according to claim 1, characterized in that: - The Euglena β-glucan is extracted by pre-hydrolysis SBE technology and has a molecular weight of 5-50kDa; - The particle size of the nuciferine nanoliposome is ≤100nm and the embedding rate is ≥90%.

3. The method for preparing the food according to claim 1, comprising the steps of: - S1. Mix the new food raw materials (euglena, Haematococcus pluvialis, and Ampelopsis grossedentata leaves) with medicinal and edible ingredients (lotus leaves, hawthorn leaves, and mulberry leaves), and extract the active ingredients using pre-hydrolysis SBE technology; - S2. The extract was mixed with whey protein and treated with enzymatic hydrolysis (45°C, pH 6.5, 2h); - S3. Metabolic regulators (CLA, L-carnitine) were formulated into pH-responsive microcapsules (using alginate-chitosan composite as the wall material); - S4. Modular formulas can be combined as needed to make powders, tablets or liquid foods to meet energy density requirements of 1.2-1.5kcal / mL.

4. The preparation method according to claim 3, wherein: - The final product must pass GB 29922-2013 complete nutritional formula food certification, and the osmotic pressure must be controlled at 300-450mOsm / L.

5. A product line iterative development method, comprising: - Basic formula (powder) → Function-enhanced type (added probiotics) → Scenario-adapted type (ready-to-drink liquid food).

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