Synthesis method of parachlorophenylhydrazine hydrochloride

A technology for the synthesis of chlorophenylhydrazine hydrochloride, which is applied in the preparation of hydrazine, organic chemistry, etc., can solve the problems of carcinogenicity, great harm to the human body, and the preparation method is not friendly to the environment, and achieve low cost and high product yield. High and improve the effect of enterprise economic benefits

Inactive Publication Date: 2016-08-10
JIANGSU TUOQIU AGRI CHEM CO LTD
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Problems solved by technology

Because of its salty taste and cheap price, it is often used as an unreasonable substitute for table salt in illegal food production. Because sodium nitrite is pois

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Embodiment Construction

[0038] The present invention will be described in detail below in conjunction with specific embodiments. The following examples will help those skilled in the art to further understand the present invention, but do not limit the present invention in any form. It should be pointed out that for those of ordinary skill in the art, a number of modifications and improvements can be made without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

[0039] The method for synthesizing p-chlorophenylhydrazine hydrochloride according to the present invention includes the following steps:

[0040] 1. Diazotization of p-chloroaniline

[0041] 1a) Take the reactor, add 250~350kg of toluene, stir, add 150~250kg of p-chloroaniline, heat up to 25~30℃, keep for 50~70min, until the p-chloroaniline is completely dissolved, get the mixed solution, pump the mixed solution into High-level liquid storage tank, ready for use;

[0042] 1b)...

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Abstract

The invention provides a synthesis method of parachlorophenylhydrazine hydrochloride. The synthesis method comprises the following steps: 1. diazotization of parachloroaniline; 2. reduction; 3. acidification; and 4. after-treatment. The synthesis method has the advantages of environment-friendly raw materials, simple synthesis technique, environment friendliness, low cost, high product yield, energy saving and consumption reduction, effectively lowers the production cost, and can enhance the economic benefit of the enterprise.

Description

Technical field [0001] The invention relates to a method for synthesizing p-chlorophenylhydrazine hydrochloride. Background technique [0002] P-chlorophenylhydrazine hydrochloride is an important pharmaceutical and pesticide intermediate. An important starting material for a new generation of anti-inflammatory analgesics. CAS number: 1073-70-7, molecular formula: C6H8Cl2N2, molecular weight: 179.0486, English name: 4-chlorophenylhydrazine hydrochloride, appearance is white or light red powder, melting point 210~218℃, moisture content ≤ 2%, content ≥ 98%. [0003] P-chlorophenylhydrazine hydrochloride is an important intermediate for the synthesis of pyraclostrobin. Pyraclostrobin is a new type of methoxy acrylate fungicide, a new broad-spectrum fungicide, and its mechanism of action is mitochondrial respiratory inhibition It prevents the mitochondria from producing and providing the energy required for the normal metabolism of the cell, eventually leading to cell death. [0004] ...

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Application Information

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IPC IPC(8): C07C241/02C07C243/22
CPCC07C241/02C07C245/20C07C243/22
Inventor 廖大章廖大泉孙雅泉孙伯文
Owner JIANGSU TUOQIU AGRI CHEM CO LTD
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