Synthesis method of parachlorophenylhydrazine hydrochloride

Abstract

The invention provides a synthesis method of parachlorophenylhydrazine hydrochloride. The synthesis method comprises the following steps: 1. diazotization of parachloroaniline; 2. reduction; 3. acidification; and 4. after-treatment. The synthesis method has the advantages of environment-friendly raw materials, simple synthesis technique, environment friendliness, low cost, high product yield, energy saving and consumption reduction, effectively lowers the production cost, and can enhance the economic benefit of the enterprise.

Description

Technical field [0001] The invention relates to a method for synthesizing p-chlorophenylhydrazine hydrochloride. Background technique [0002] P-chlorophenylhydrazine hydrochloride is an important pharmaceutical and pesticide intermediate. An important starting material for a new generation of anti-inflammatory analgesics. CAS number: 1073-70-7, molecular formula: C6H8Cl2N2, molecular weight: 179.0486, English name: 4-chlorophenylhydrazine hydrochloride, appearance is white or light red powder, melting point 210~218℃, moisture content ≤ 2%, content ≥ 98%. [0003] P-chlorophenylhydrazine hydrochloride is an important intermediate for the synthesis of pyraclostrobin. Pyraclostrobin is a new type of methoxy acrylate fungicide, a new broad-spectrum fungicide, and its mechanism of action is mitochondrial respiratory inhibition It prevents the mitochondria from producing and providing the energy required for the normal metabolism of the cell, eventually leading to cell death. [0004] ...

AI Technical Summary

Problems solved by technology

Because of its salty taste and cheap price, it is often used as an unreasonable substitute for table salt in illegal food production. Because sodium nitrite is poisonous, food containing industrial salt is very harmful to the human body and has carcinogenicity. Therefore, its preparation method not friendly to the environment