Continuous production method and device of 4-chlorophenylhydrazine hydrochloride

Abstract

The invention relates to the field of organic synthesis and in particular relates to a continuous production method and device of 4-chlorophenylhydrazine hydrochloride. A continuous production mannercombining tubular reaction and kettle type reaction is adopted; diazotization reaction is carried out in a tubular reactor and raw materials are uniformly mixed; the reaction is stably carried out, the safety of the reaction is improved, side reaction is reduced and the purity and the yield of a final product are improved; reduction reaction and acidification reaction are carried out in a reduction reaction kettle so that the production continuity is improved, the total reaction time is reduced, the production efficiency is improved, the energy consumption is saved and the production cost is reduced; the yield of the prepared 4-chlorophenylhydrazine hydrochloride is greater than 90 percent and the purity is greater than 96 percent; the continuous production method and device meet industrial requirements and are suitable for industrial continuous production.

Description

technical field

[0001] The invention relates to the field of organic synthesis, in particular to a continuous production method of p-chlorophenylhydrazine hydrochloride and a device thereof. Background technique

[0002] p-Chlorophenylhydrazine hydrochloride is a widely used organic synthesis intermediate, which can be used in the synthesis of dyes, medicines and other chemicals. Its molecular formula is C 6 h 8 Cl 2 N 2 , the molecular weight is 179, the appearance is white or light red powder, and the melting point is 210-218 ℃. The main applications of p-chlorophenylhydrazine hydrochloride in chemical synthesis are: (1) for central nervous system drug thieno[2,3',2,3]thiopyran[4,5,c]-pyrazoline -Synthesis of 3(4H)-ketone, blocking the ascending activation system of the brainstem reticular structure; (2) for the synthesis of anxiolytics benzothiophene [5,4-c] pyrazoline; (3) with Used in the synthesis of salicylic acid anti-inflammatory drugs; (4) for the synthesis of...

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