32 results about "Cefazedone sodium" patented technology

The invention relates to a preparation method of a novel anti-infective drug. The preparation method comprises the following steps: (1) salifying, namely putting cefazedone and a sodium acetate solvent in absolute methanol to have a salifying reaction, and controlling the temperature in the range of 10-30 DEG C after the cefazedone is completely dissolved, (2) decoloring, namely adding active carbon to a reaction liquid, stirring and decoloring, and removing the active carbon by filtering, keeping the temperature of the filtrate in the range of 10-30 DEG C, and then re-filtering; (3) crystalizing, namely slowly and dropwise adding a certain amount of ethanol to the filtered filtrate at a rate of 20L / H under a stirring condition until the system is turbid, growing crystals for 0.5 to 1 hour, next, adding a certain amount of acetone, growing crystals for 0.5 to 1 hour, and then reducing the temperature to 5 DEG C at a temperature reducing rate of 5-15 DEG C per hour, and stirring by keeping the stirring speed in the range of 80-120r / min for crystallization, and growing the crystals for 1-3 hours; and (4) drying, namely filtering and washing the filter cake, and drying to obtain refined cefazedone sodium. Compared with the prior art, the preparation method is simple to operate, low in cost and high in yield, and pollution is greatly reduced; and the obtained refined cefazedone sodium is low in moisture content, low in impurity content and high in stability.

The invention provides a preparation method of Cefazedone sodium salt, comprising the following main steps: adding Cefazedone acid into a methanol-isopropanol mixed solvent, adding methanol / triethylamine to carry out a salt forming reaction, regulating pH by adding acetic acid, adding sodium acetate and seed crystals to precipitate out sodium salt, growing the grain, adding acetone to completely precipitate out crystals, carrying out programmable heating and vacuum drying to obtain a finished product. an anhydrous system is adopted in the method without the need of humidification, and moisturecan reach 0.5% and below; the content of residual solvent is low, and the contents of methanol, isopropanol and acetone are all below 0.1%; the production cycle is shortened and the production cost is lowered; and there are few crystal impurities and the purity is high.

The invention relates to an enzymatic synthesis technology of a novel cephalo-type anti-infection drug. The technology comprises the following steps: preparing TDA hydrochloride from TDA, purifying, processing to prepare TDA sodium salt, and directly carrying out enzymatic synthesis of cefazedone sodium in a water phase under the action of immobilized penicillin acylase. The enzymatic synthesis technology has the advantages of operating step simplification, implementation of a reaction in the water phase, mild reaction conditions, few byproducts, great reduction of energy consumption and organic wastewater discharge, cost reduction, small pollution to environment, good environmental protection property, and industrialization requirement meeting; and the technology greatly improves the product yield and the product yield, the product purity is greater than 99.9%, and the total yield is greater than 90%.