Synthetic process of novel cephalosporin anti-infective drug

A synthesis process and technology for cephalosporins, applied in the field of drug synthesis, can solve problems such as being unsuitable for industrialized large-scale production, high industrial production cost, difficult to find purification methods, etc., and achieve reduction of by-products, product cost reduction, and easy post-processing. Effect
CN105017285AActive Publication Date: 2015-11-04SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
5 Cites 3 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
Publication Date
2015-11-04

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a synthetic process of a novel cephalosporin anti-infective drug. A thioester compound (formula III) synthesized by adopting 3,5-dichloro-4-pyridone-1-acetic acid and 2-thiol-5-methyl-1,3,4-thiadiazole as raw materials is directly reacted with 7-ACA in one step to successfully prepare cefazedone sodium. According to the synthetic process disclosed by the invention, the operating steps are simplified, so that the production conditions are milder, the generation of byproducts is reduced, and the production technology is simpler; and moreover, the product yield and purity are greatly improved, the cost is reduced, the environmental pollution is little, and the synthetic process is higher in environmental protection, so that the process accords with the requirement of industrialization.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of drug synthesis, in particular to a synthesis process of a novel cephalosporin anti-infective drug cefzidone sodium. Background technique

[0002] Cefazedone sodium (Cefazedone) belongs to the first generation of injectable cephalosporin antibiotics, and its curative effect on various Gram-positive bacteria and Gram-negative bacteria, including Staphylococcus aureus, Streptococcus, and Enterococcus, is superior to similar drugs— The drug resistance of cefazolin and cephalothin is obviously better than that of the latter. They are classic broad-spectrum antibiotics with broad antibacterial spectrum and wide clinical application. A total of 732 patients in 7 foreign countries and 35 hospitals participated in the clinical research results showed that cefzidome was effective against urinary system infection, respiratory tract infection, surgical-skin infection and gynecological infection caused by gram-positive and nega...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More