Novel compound of anti-infection drug and preparation method thereof

A drug compound and anti-infection technology, applied in the field of medicine, can solve the problems of easy residue, high stability, poor fluidity, etc., and achieve the effects of reducing impurities and moisture content, improving stability and good fluidity

Active Publication Date: 2015-09-30
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For example, in CN 101584671A, the cefazedone sodium solid is dissolved in water, after activated carbon decolorization and filtration, acetone crystallization is added to the filtrate, and the crystals are filtered and dried to obtain cefazedone sodium crystals. This method is only through conventional drying. There are problems such as low drying efficiency and difficulty in reproducing moisture control in different batches of products.
[0006] CN 102924482A discloses a preparation method of low-water-content cefazedone sodium, which has the following disadvantages: (1) sodium methoxide is used as a salt-forming solvent, and the alkalinity is too strong, so that the cefazedone β-lactam ring is easily destroyed, High impurity content, strong corrosiveness, and large pollution; (2) Isopropanol is used as the crystallization solvent, which has a high boiling point and low volatility, and is easy to remain in the product, increasing the impurity content; (3) The crystallization process uses Seed Crystal Generation by Ultrasonic Oscillation Seeding Method
This preparation method is loaded down with trivial details operation, high to equipment requirement, pollution is big, cost is also high, and the obtained product impurity content is high, and yield is low; (4) prepara...

Method used

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  • Novel compound of anti-infection drug and preparation method thereof
  • Novel compound of anti-infection drug and preparation method thereof
  • Novel compound of anti-infection drug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: a kind of preparation method of anti-infective drug compound, the steps are as follows:

[0032] Dissolve 1.0Kg of cefazedone sodium solid in 4.0L of pure aqueous solution at 15°C; first add a mixed solvent of isopropanol and acetone with a total volume of 8.0L, and the volume ratio of isopropanol to acetone is 1:1, Stir while adding, control the temperature at 15°C, and grow the crystal for 0.5 hours; then add a mixed solvent of isopropanol and acetone with a total volume of 12.0L, the volume ratio of isopropanol and acetone is 1:1, and grow the crystal for 2 hours. Hours later, the temperature was lowered to 5°C at a speed of 5°C / hour, and then the stirring speed was kept at 80 rpm to stir and crystallize and grow crystals for 1 hour; filter, dry at 40°C, and dry under reduced pressure to obtain 0.958Kg of cefazedone sodium crystalline compound, The yield was 95.8%.

[0033] The prepared X-ray powder diffraction pattern obtained by measuring the cefazed...

Embodiment 2

[0034] Embodiment 2: a kind of preparation method of anti-infective drug compound, the steps are as follows:

[0035] Dissolve 1.0Kg of cefazedone sodium solid in 8.0L of pure aqueous solution at 35°C; first add a mixed solvent of anhydrous isopropanol and anhydrous acetone with a total volume of 10.0L at a rate of 4ml / min, and anhydrous isopropanol The volume ratio of propanol to anhydrous acetone is 1:1, stir while adding, control the temperature at 35°C, grow the crystal for 1 hour; then add anhydrous isopropanol with a total volume of 25.0L at a speed of 4ml / min , a mixed solvent of anhydrous acetone, the volume ratio of anhydrous isopropanol to anhydrous acetone is 1:1, after growing crystals for 5 hours, cool down to 5°C at a speed of 15°C / hour, and then maintain a stirring speed of 120 rpm / The crystallization was stirred for 3 hours, and the crystal was grown for 3 hours; filtered, 50° C., and dried under reduced pressure for 12 hours to obtain 0.925 Kg of cefazedone s...

Embodiment 3

[0037] Embodiment 3: a kind of preparation method of anti-infective drug compound, the steps are as follows:

[0038] Dissolve 1.0Kg of cefazedone sodium solid in 6.0L of pure aqueous solution at 25°C; first add a mixed solvent of anhydrous isopropanol and anhydrous acetone with a total volume of 9.0L at a rate of 3ml / min, and anhydrous isopropanol The volume ratio of propanol to anhydrous acetone is 1:1, stir while adding, control the temperature at 25°C, and grow crystals for 0.7 hours; then add anhydrous isopropanol with a total volume of 19.0L at a speed of 3ml / min , a mixed solvent of anhydrous acetone, the volume ratio of anhydrous isopropanol to anhydrous acetone is 1:1, after growing crystals for 3.5 hours, cool down to 5°C at a speed of 10°C / hour, and then maintain a stirring speed of 100 rpm / The crystallization was stirred for 2 hours, and the crystal was grown for 2 hours; filtered, 45° C., and dried under reduced pressure for 11 hours to obtain 0.936 Kg of cefazedon...

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Abstract

The invention belongs to the technical field of medicine and particular relates to a novel compound of an anti-infection drug and a preparation method thereof. According to the compound, characteristic peaks are displayed at diffraction angles of 3.5 degrees, 4.6 degrees, 8.4 degrees, 12.5 degrees, 13.8 degrees, 16.2 degrees, 19.0 degrees, 19.5 degrees, 20.0 degrees, 21.1 degrees, 27.1 degrees and 33.1 degrees in an X-ray powder diffraction pattern obtained through measurement by Cu-KAlpha rays. The invention further relates to powder injection containing 100% cefazedone sodium. The new crystal from of the compound is different from that in the prior art, through experimental verification, it is surprised to find that compared with the prior art, the powder injection obtained by direct subpackage of the compound of the novel crystal form does not need any auxiliary material and is good in liquidity, the content of impurities and moisture is reduced effectively, the safety of products is good, and the stability is high.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a novel compound of an anti-infection drug and a preparation method thereof. Specifically, it relates to a cefazedone sodium crystal compound and a preparation method thereof. Background technique [0002] Infectious diseases are a common and frequently-occurring disease in clinical practice. According to the report of the World Health Organization (WHO), the number of deaths from infectious diseases is as high as 33.3% of the total number of deaths from various causes. Cephalosporins are the most widely used first-line drugs in clinical practice. In recent years, due to the abuse of antibiotics, many "super bacteria" have emerged, and the problem of bacterial drug resistance has become increasingly serious. The "Administrative Measures for the Clinical Application of Antibacterial Drugs" officially implemented by the state restricts the clinical application of the third-generat...

Claims

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Application Information

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IPC IPC(8): C07D501/36C07D501/12A61P31/04
CPCC07D501/12C07D501/36
Inventor 孙松赵金龙张锋
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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