46 results about "Anti-infection drugs" patented technology

The invention relates to an anti-infection and anticoagulation coating for central venous catheters and a preparation method thereof. The anti-infection and anticoagulation coating comprises the following raw materials in percentage by weight: 0.81-2.0% of support polymer, 1.2-2.8% of super-lubrication hydrophilic polymer, 0.32-1.0% of anti-infection drug, 0.1-1.5% of coupling agent, and 90-97% of water. The anti-infection and anticoagulation coating has the advantages that the anti-infection and anticoagulation double functions are realized; the coating technology is simple, the effect is obvious, and the application range is wide.

The invention provides a construction method of a kidney transplantation anti-infection drug dosage prediction model. The method comprises the following steps: establishing a group pharmacokinetic model of an anti-infective drug by adopting a nonlinear mixed effect model, a two-atrioventricular model and a mixed residual model through plasma concentration analysis, and calculating pharmacokinetic parameters of the corresponding model; and carrying out related hypothesis testing and estimation on the obtained model pharmacokinetic parameters based on a bootstrap method, visual prediction testing and normalized prediction distribution errors, and completing the steps of stability and prediction capability evaluation and the like. According to the established pharmacokinetic model of the kidney transplantation patient population, the reasonable judgment on the medication scheme information is accurately realized, the reference of the optimal dosage is expected to be provided in the infection prevention and treatment process, the adverse reaction risk is reduced, the curative effect is improved, and finally the individualized administration of the anti-infection medicine of the kidney transplantation patient is realized.

The invention discloses a berberine hydrochloride and malic acid eutectic compound as well as a preparation method, a composition and application thereof. Specifically, the invention discloses a novelberberine hydrochloride and malic acid eutectic substance which takes berberine hydrochloride as a medicinal active component and malic acid as a eutectic precursor, a preparation method of the berberine hydrochloride and malic acid eutectic substance, and application of the berberine hydrochloride and malic acid eutectic substance as a medicinal active ingredient in preparation of medicines forpreventing and treating cardiovascular diseases, resisting viruses and cancers, reducing blood fat, reducing blood sugar, resisting inflammation, resisting bacteria and resisting infection.

The invention relates to a preparation method and application of effective components of polygonum capitatum, and belongs to the field of extraction of effective components of traditional Chinese medicines. The preparation method comprises the following steps: a, taking polygonum capitatum medicinal raw material, adding water for extraction, so as to obtain water extracting solution; b, processing the water extracting solution by using a macroporous adsorption resin chromatographic column; c, firstly eluting the sampled macroporous adsorption resin chromatographic column by using water, then eluting by using 70-95wt% ethanol, and collecting eluent I; d, processing the eluent I by a polyamide chromatographic column; e, recovering effluent liquid from the sampled polyamide chromatographic column, eluting by using 40-95wt% ethanol, collecting eluent II; f, mixing the effluent liquid and the eluent II, recovering ethanol, concentrating and drying to finally obtain the effective components of polygonum capitatum. The preparation method has the beneficial effect that the effective components of the polygonum capitatum, which has strong antibacterial effect and can be used for preparing anti-infection drugs can be prepared by reasonable extracting and separating methods.

The invention provides a covered stent. The covered stent comprises a covered stent body and a medicine storage device. The covered stent body is internally provided with a circulation space with two communicated ends; the medicine storage device is fixed to the covered stent body, at least part of the medicine storage device is located on the outer side of the covered stent body, a medicine storage space is formed in the medicine storage device, a medicine feeding hole is formed in the medicine storage device, and the medicine storage space is communicated with the external environment through the medicine feeding hole. Compared with the prior art, the covered stent provided by the invention has the advantages that antibacterial and anti-infection medicines can be stored in the medicine storage device, and the medicines can be released outwards through the administration holes, so that the covered stent has better anti-infection capability.

The invention relates to an enzymatic synthesis technology of a novel cephalo-type anti-infection drug. The technology comprises the following steps: preparing TDA hydrochloride from TDA, purifying, processing to prepare TDA sodium salt, and directly carrying out enzymatic synthesis of cefazedone sodium in a water phase under the action of immobilized penicillin acylase. The enzymatic synthesis technology has the advantages of operating step simplification, implementation of a reaction in the water phase, mild reaction conditions, few byproducts, great reduction of energy consumption and organic wastewater discharge, cost reduction, small pollution to environment, good environmental protection property, and industrialization requirement meeting; and the technology greatly improves the product yield and the product yield, the product purity is greater than 99.9%, and the total yield is greater than 90%.

The invention discloses an absorbable anti-adhesion hernia repairing patch and a preparation method thereof. The repairing patch comprises an upper-layer mesh and a lower-layer mesh, an arc-shaped connecting body is arranged between the upper-layer mesh and the lower-layer mesh, the edge of the arc-shaped connecting body is connected with the upper-layer mesh through non-absorbable lines, and the bottom of the arc-shaped connecting body is connected with the lower-layer mesh through absorbable lines; the lower-layer mesh and the arc-shaped connecting body are both made from an absorbable material; the lower-layer mesh is provided with multiple slow-release anti-infection layers which are distributed in a concentric annulus mode, and the circle center of the concentric annulus coincides with the center of the lower-layer mesh; the slow-release anti-infection layers are formed by applying slow-release anti-infection drugs on the lower-layer mesh and then drying the drugs at normal temperature. The arc-shaped connecting body and the lower-layer mesh are both made from the biodegradable material, can be slowly metabolized in a human body, is nontoxic and harmless and can effectively isolate the wound surface from visceral organs, the condition that the wound surface directly makes contact with the peripheral tissues in the healing process is avoided, and adhesion is effectively prevented.

The invention provides a nano-silver emulsifiable paste and its preparation method and relates to the field of medicines. The nano-silver emulsifiable paste is an O/W type emulsifiable paste or W/O type emulsifiable paste which is prepared by a certain preparation technology with nano-silver being used as a main drug. The nano-silver emulsifiable paste can be used for treating infection of infected wounds and body surface chronic ulcer (venous ulcer, pressure ulcer and the like) caused by burn and scald and physical and mechanical damage and for promoting healing of the wounds. The O/W type emulsifiable paste is similar to a moistening burn cream and can provide burn and scald wounds with a moistening environment which is beneficial to tissue regeneration. Simultaneously, due to specific high antibacterial activity and good wound heating promotion effect of the nano-silver, the nano-silver emulsifiable paste is better than the moistening burn cream; and in comparison with sulfadiazine silver and other external-use anti-infection drugs, the nano-silver emulsifiable paste is beneficial to wound healing, has no bacterial drug resistance and has high antibacterial activity.

The invention relates to the technical field of medical catheters, in particular to a hemodialysis medical catheter for dialysis and a preparation method of the hemodialysis medical catheter. The medical catheter comprises a catheter body and an antibacterial coating coated on the surface of the catheter body, wherein the catheter body is prepared from polyvinyl chloride plastic, modified filter residues, magnesium carbonate, silicon dioxide and ethidene diamine; and the antibacterial coating is prepared from copper powder and an anti-infection drug. Mulberry bark is used as a raw material, is treated by a propyl alcohol solution, and cooperates with the magnesium carbonate, the silicon dioxide and the ethidene diamine, so that the antibacterial performance of the medical catheter is improved. The antibacterial coating is prepared from anti-infection medicine raw materials and sprayed to the surface of the medical catheter, and the antibacterial performance of the medical catheter can be further improved.

The invention relates to the field of biological engineering, in particular to an Escherichia coli lyase as well as a preparation method and application thereof as an anti-infection drug. The Escherichia coli lyase is characterized in that an amino acid sequence is Seq ID NO.2. Enzymic preparations capable of effectively killing Escherichia coli are developed by utilizing a bioengineering technology. The preparations can be used independently or can be compounded to use, can specifically deactivate multiple Escherichia coli, and a safe and nontoxic enzyme preparation source with no side effect can be provided for controlling the Escherichia coli in garget at present.

Belonging to the field of medical technology, the invention discloses a postoperative wound anti-infection drug and a preparation method thereof. The postoperative wound anti-infection drug is prepared from the following components by weight: 15-20 parts of an arundina graminifolia extract, 10-15 parts of mangnolia officinalis, 8-12 parts of phellodendron, 5-10 parts of peppermint oil, 2-5 parts of methyl violet, 5-8 parts of indigo naturalis, 16-19 parts of flaxseed oil, 8-11 parts of citric acid, and 35-42 parts of anhydrous ethanol. The anti-infection drug prepared according to the invention can effectively inhibit the production of bacterial toxin, reduce the postoperative wound infection rate, at the same time alleviate the wound pain, make the wound heal quickly, and reduce the generation of scars, and after being made into a spray, is convenient to preserve and carry, and is convenient to take.

The present invention relates to antibody engineering and anti-infection drug field, provides a method for detection and evaluation of biological functions of a molecule and a medicine and use thereof, and particularly relates to a method for detection of biological functions of (human) anti-human hepatitis B virus antibody. The method can effectively detect the level of the biological functions of the molecule, the medicine and the (human) anti-human hepatitis B virus antibody. According to the method, biological activity of a forerunner molecule and drug can be defined by detection of the ability of the to-be-detected forerunner molecule and drug to neutralize pathogene key molecules in animal body and the ability of the to-be-detected forerunner molecule and drug to break immune tolerance and reconstruct immune protection in the animal body. The method can be used for rapid detection of virus clearing ability and virus infection and pathogenesis control ability of antibodies and other anti-infection drugs. The method has the advantages of simple operation process and good the repeatability, and is a supplement to methods in the prior art for detection and evaluation of functionality of antiviral drugs, the method is established for providing a new choice for research and development of drugs of cell and animal infection model virus.

Oxazolidinone-adenosine type compounds have the following structural general formula described in the specification; the compounds have better inhibition and killing effects on various pathogenic bacteria; a part of compounds have higher bacteriostatic activity than penicillin G, kalamycin, ketoconazole and linezolid and can be used for preparation of anti-infection drugs; the invention discloses a preparation method and a biological activity of the compounds.

The invention discloses 4'-N-demethyl-vicenistatin as well as a preparation method and application thereof, and belongs to the technical field of natural products. According to the present invention, the N-demethylation vicenatistatin derivative 4'-N-demethylation-vicenistatin is separated from the N-methyltransferase inactivated mutant strain SCSIO Mla-L010/[delta] vicG of S.parvus SCSIO Mla-L010, the test result shows that the 4'-N-demethylation-vicenistatin has significant inhibitory activity on a variety of fungi and bacteria, the important value of the 4'-N-demethylation-vicenistatin in the development of anti-infection drugs is displayed, the antibacterial activity of the 4'-N-demethylation-vicenistatin on fungi Candida albicans is 2-4 times stronger than the antibacterial activity of vicenistatin on fungi Candida albicans, and the derivative with the structure has better patent medicine potential. In addition, the 4'-N-demethyl-vicenistatin also shows relatively strong cytotoxic activity on a plurality of cancer cells, and has the potential of being developed into an anti-tumor drug.

The invention provides a compound polysaccharide immunological enhancement agent for pets and a preparation method and application thereof. The enhancement agent is prepared from bursa fabricius bioactive peptide BP-IV, mannan oligosaccharide, vitamin A, adhesive, disintegrant and lubricant. The enhancement agent has a good immunological enhancement effect on the pets, the capacity for the organisms to resist pathogen infection can be enhanced, and the health level of the organisms is improved. Compared with existing anti-infection medicine, the enhancement agent is a good pet compound for enhancing immunity, can be used for clinically preventing infectious diseases, and has high application value in improving the immunological capacity of the organisms of the pets.

The invention belongs to the technical field of medicine and particular relates to a novel compound of an anti-infection drug and a preparation method thereof. According to the compound, characteristic peaks are displayed at diffraction angles of 3.5 degrees, 4.6 degrees, 8.4 degrees, 12.5 degrees, 13.8 degrees, 16.2 degrees, 19.0 degrees, 19.5 degrees, 20.0 degrees, 21.1 degrees, 27.1 degrees and 33.1 degrees in an X-ray powder diffraction pattern obtained through measurement by Cu-KAlpha rays. The invention further relates to powder injection containing 100% cefazedone sodium. The new crystal from of the compound is different from that in the prior art, through experimental verification, it is surprised to find that compared with the prior art, the powder injection obtained by direct subpackage of the compound of the novel crystal form does not need any auxiliary material and is good in liquidity, the content of impurities and moisture is reduced effectively, the safety of products is good, and the stability is high.

The invention relates to an anti-infection coating capable of realizing immediate construction in an operation as well as a preparation method and application of the anti-infection coating. The anti-infection coating comprises an anti-infection drug coating covering the surface of a main body structure and a high polymer material coating covering the surface of the anti-infection drug coating, and the high polymer material comprises chitosan and beta-sodium glycerophosphate. The temperature-sensitive phase-change high polymer material coating can be subjected to rapid phase change under a heating condition, and the surface of the main body structure is covered with an anti-infection drug, so that immediate construction in an operation is realized, the defect that in the prior art, an antibacterial coating needs to be prepared before the operation, and then the storage problem needs to be considered is overcome. Meanwhile, the content of the anti-infection drug can be adjusted according to the infection degree of the focus in the operation, and personalized treatment is achieved. Meanwhile, the biocompatibility of the anti-infection coating is good, the local slow release behavior of the anti-infection drug can be achieved, and the action time of the drug is remarkably prolonged.

The invention provides a medicine-carrying aquogel coating and a preparation method and application thereof. Alumina aquogel serves as a coating substrate and carries anti-infection medicine, and the nanometer medicine-carrying aquogel coating is obtained; due to the characteristics that alumina aquogel is not degraded and is slowly absorbed by human bodies, the anti-infection medicine carried by the medicine-carrying coating can be stored in the coating all the time, and the anti-infection effect of the coating can be achieved continuously; when the coating is applied to an implant material, a composite implant body is obtained and implanted into a human body, and chronic infection especially the chronic infection caused by the implant material can be effectively stopped when damaged parts are repaired.