47 results about "Anti-infection drugs" patented technology

The invention relates to an anti-infection and anticoagulation coating for central venous catheters and a preparation method thereof. The anti-infection and anticoagulation coating comprises the following raw materials in percentage by weight: 0.81-2.0% of support polymer, 1.2-2.8% of super-lubrication hydrophilic polymer, 0.32-1.0% of anti-infection drug, 0.1-1.5% of coupling agent, and 90-97% of water. The anti-infection and anticoagulation coating has the advantages that the anti-infection and anticoagulation double functions are realized; the coating technology is simple, the effect is obvious, and the application range is wide.

The invention provides a construction method of a kidney transplantation anti-infection drug dosage prediction model. The method comprises the following steps: establishing a group pharmacokinetic model of an anti-infective drug by adopting a nonlinear mixed effect model, a two-atrioventricular model and a mixed residual model through plasma concentration analysis, and calculating pharmacokinetic parameters of the corresponding model; and carrying out related hypothesis testing and estimation on the obtained model pharmacokinetic parameters based on a bootstrap method, visual prediction testing and normalized prediction distribution errors, and completing the steps of stability and prediction capability evaluation and the like. According to the established pharmacokinetic model of the kidney transplantation patient population, the reasonable judgment on the medication scheme information is accurately realized, the reference of the optimal dosage is expected to be provided in the infection prevention and treatment process, the adverse reaction risk is reduced, the curative effect is improved, and finally the individualized administration of the anti-infection medicine of the kidney transplantation patient is realized.

A method of administering an aerosolized anti-infective, such as a glycopeptide, to the respiratory system of a patient. A ratio of an amount of the glycopeptide, such as vancomycin, delivered to the pulmonary system of the patient in a 24 hour period to a minimum inhibitory amount for the target organ for the same period is about 2 or more. A system to introduce aerosolized medicament to a patient may include a humidifier coupled to an inspiratory limb of a ventilator circuit wye, where the humidifier supplies heated and humidified air to the patient, and an endotracheal tube having a proximal end coupled to a distal end of the ventilator circuit wye. The system may also include a nebulizer coupled to the endotracheal tube, where the nebulizer generates the aerosolized medicament.

The invention provides a piglet colibacillosis lyophilized serum immunoglobulin preparation. The piglet colibacillosis lyophilized serum immunoglobulin preparation is composed of following components in parts by weight: 5.0-55.0 parts of saccharicterpenin, 0.005-0.01 parts of hyoscyamine, 55.0-95.0 parts of serum immunoglobulin. The piglet colibacillosis lyophilized serum immunoglobulin preparation disclosed by the invention has higher stability, can inhibit and kill colon bacillus more sustainably and more sufficiently, and has more remarkable anti-infection effects, so that the purpose of preventing and treating diarrhea of the piglet due to the colon bacillus can be realized more easily. Meanwhile, the piglet colibacillosis lyophilized serum immunoglobulin preparation is not only a pure natural environment-friendly type green and anti-infection drug without medicine residue, public hazard, drug tolerance and side effect, but is also an excellent medicine for replacing various harmful antibiotic medicines.

An improved post-operative dressing for providing both breast and, notably, nipple reconstruction and which in particular establishes custom lateral supporting of the nipple annulus. A body is constructed of a medical grade silicone and exhibits a three dimensional shape adapted for placement over the reconstructed breast and an aperture defined by an inner rim configured within the body is adapted to seat therethrough an associated nipple graft in a laterally supporting and non-pressure applied fashion. A number of secondary advantages incorporated into the body include each of apertures for breathability, suction / adherence properties, and impregnation or entrainment within the body inner surface of any form of anti-infection medicine.

The invention discloses a berberine hydrochloride and malic acid eutectic compound as well as a preparation method, a composition and application thereof. Specifically, the invention discloses a novelberberine hydrochloride and malic acid eutectic substance which takes berberine hydrochloride as a medicinal active component and malic acid as a eutectic precursor, a preparation method of the berberine hydrochloride and malic acid eutectic substance, and application of the berberine hydrochloride and malic acid eutectic substance as a medicinal active ingredient in preparation of medicines forpreventing and treating cardiovascular diseases, resisting viruses and cancers, reducing blood fat, reducing blood sugar, resisting inflammation, resisting bacteria and resisting infection.

The invention relates to a preparation method and application of effective components of polygonum capitatum, and belongs to the field of extraction of effective components of traditional Chinese medicines. The preparation method comprises the following steps: a, taking polygonum capitatum medicinal raw material, adding water for extraction, so as to obtain water extracting solution; b, processing the water extracting solution by using a macroporous adsorption resin chromatographic column; c, firstly eluting the sampled macroporous adsorption resin chromatographic column by using water, then eluting by using 70-95wt% ethanol, and collecting eluent I; d, processing the eluent I by a polyamide chromatographic column; e, recovering effluent liquid from the sampled polyamide chromatographic column, eluting by using 40-95wt% ethanol, collecting eluent II; f, mixing the effluent liquid and the eluent II, recovering ethanol, concentrating and drying to finally obtain the effective components of polygonum capitatum. The preparation method has the beneficial effect that the effective components of the polygonum capitatum, which has strong antibacterial effect and can be used for preparing anti-infection drugs can be prepared by reasonable extracting and separating methods.

The invention relates to the fields of antibody engineering and antiviral medicine, and relates to a method for rapidly and effectively measuring the antiviral function of recombinant human anti-hepatitis B virus antibody. The invention utilizes the technology of sinking virus complexes to establish a new method for detecting and evaluating the anti-virus ability of molecules. The method is to detect the anti-virus and anti-infection ability of the molecule by detecting the ability of the test molecule to induce a sinking pathogenic complex in serum; the pathogen is a virus. The method can be used to quickly detect the ability of antibodies and other anti-infection drugs to clear virus and control virus infection. The method is simple to operate and the results are reproducible, and it is a supplement to the existing antiviral drug functional detection and evaluation methods. a new choice. The invention also relates to a detection reagent for antiviral infection activity, a sinking pathogenic complex occurring in the detection process and the application of the above detection method.

The invention provides a covered stent. The covered stent comprises a covered stent body and a medicine storage device. The covered stent body is internally provided with a circulation space with two communicated ends; the medicine storage device is fixed to the covered stent body, at least part of the medicine storage device is located on the outer side of the covered stent body, a medicine storage space is formed in the medicine storage device, a medicine feeding hole is formed in the medicine storage device, and the medicine storage space is communicated with the external environment through the medicine feeding hole. Compared with the prior art, the covered stent provided by the invention has the advantages that antibacterial and anti-infection medicines can be stored in the medicine storage device, and the medicines can be released outwards through the administration holes, so that the covered stent has better anti-infection capability.

The invention relates to an enzymatic synthesis technology of a novel cephalo-type anti-infection drug. The technology comprises the following steps: preparing TDA hydrochloride from TDA, purifying, processing to prepare TDA sodium salt, and directly carrying out enzymatic synthesis of cefazedone sodium in a water phase under the action of immobilized penicillin acylase. The enzymatic synthesis technology has the advantages of operating step simplification, implementation of a reaction in the water phase, mild reaction conditions, few byproducts, great reduction of energy consumption and organic wastewater discharge, cost reduction, small pollution to environment, good environmental protection property, and industrialization requirement meeting; and the technology greatly improves the product yield and the product yield, the product purity is greater than 99.9%, and the total yield is greater than 90%.

The invention provides plectasin expressed through bacillus subtilis and an expressing method thereof. The sequence of the plectasin is shown as a sequence table SEQ ID No.1. The expressing method includes the steps that a plectasin gene with the signal peptide SacB and protein tag 6*His-SUMO is connected onto an expression vector pGJ148 and then the connected product is electrically transferred into competent escherichia coli cells DH5alpha; correctly-authenticated recombinant plasmid is converted into the bacillus subtilis WB800N; and under the action of an inductive agent maltose, fusion protein can be expressed, and plectasin protein can be obtained by means of purification. The protein has an efficient killing effect on gram positive bacteria and does not have hemolysis to red blood cells of human bodies, production cost is reduced, and application of the plectasin as an anti-infection drug is further promoted; and meanwhile a theoretical basis is provided for application of the plectasin.

The invention discloses an absorbable anti-adhesion hernia repairing patch and a preparation method thereof. The repairing patch comprises an upper-layer mesh and a lower-layer mesh, an arc-shaped connecting body is arranged between the upper-layer mesh and the lower-layer mesh, the edge of the arc-shaped connecting body is connected with the upper-layer mesh through non-absorbable lines, and the bottom of the arc-shaped connecting body is connected with the lower-layer mesh through absorbable lines; the lower-layer mesh and the arc-shaped connecting body are both made from an absorbable material; the lower-layer mesh is provided with multiple slow-release anti-infection layers which are distributed in a concentric annulus mode, and the circle center of the concentric annulus coincides with the center of the lower-layer mesh; the slow-release anti-infection layers are formed by applying slow-release anti-infection drugs on the lower-layer mesh and then drying the drugs at normal temperature. The arc-shaped connecting body and the lower-layer mesh are both made from the biodegradable material, can be slowly metabolized in a human body, is nontoxic and harmless and can effectively isolate the wound surface from visceral organs, the condition that the wound surface directly makes contact with the peripheral tissues in the healing process is avoided, and adhesion is effectively prevented.

The invention provides a nano-silver emulsifiable paste and its preparation method and relates to the field of medicines. The nano-silver emulsifiable paste is an O / W type emulsifiable paste or W / O type emulsifiable paste which is prepared by a certain preparation technology with nano-silver being used as a main drug. The nano-silver emulsifiable paste can be used for treating infection of infected wounds and body surface chronic ulcer (venous ulcer, pressure ulcer and the like) caused by burn and scald and physical and mechanical damage and for promoting healing of the wounds. The O / W type emulsifiable paste is similar to a moistening burn cream and can provide burn and scald wounds with a moistening environment which is beneficial to tissue regeneration. Simultaneously, due to specific high antibacterial activity and good wound heating promotion effect of the nano-silver, the nano-silver emulsifiable paste is better than the moistening burn cream; and in comparison with sulfadiazine silver and other external-use anti-infection drugs, the nano-silver emulsifiable paste is beneficial to wound healing, has no bacterial drug resistance and has high antibacterial activity.

The invention relates to the technical field of medical catheters, in particular to a hemodialysis medical catheter for dialysis and a preparation method of the hemodialysis medical catheter. The medical catheter comprises a catheter body and an antibacterial coating coated on the surface of the catheter body, wherein the catheter body is prepared from polyvinyl chloride plastic, modified filter residues, magnesium carbonate, silicon dioxide and ethidene diamine; and the antibacterial coating is prepared from copper powder and an anti-infection drug. Mulberry bark is used as a raw material, is treated by a propyl alcohol solution, and cooperates with the magnesium carbonate, the silicon dioxide and the ethidene diamine, so that the antibacterial performance of the medical catheter is improved. The antibacterial coating is prepared from anti-infection medicine raw materials and sprayed to the surface of the medical catheter, and the antibacterial performance of the medical catheter can be further improved.

The invention relates to the field of biological engineering, in particular to an Escherichia coli lyase as well as a preparation method and application thereof as an anti-infection drug. The Escherichia coli lyase is characterized in that an amino acid sequence is Seq ID NO.2. Enzymic preparations capable of effectively killing Escherichia coli are developed by utilizing a bioengineering technology. The preparations can be used independently or can be compounded to use, can specifically deactivate multiple Escherichia coli, and a safe and nontoxic enzyme preparation source with no side effect can be provided for controlling the Escherichia coli in garget at present.

The invention provides an implantable prosthesis, which comprises a prosthesis body, a fixing part, a fixing part and a fixing part, wherein the prosthesis body is provided with a mounting part; the medicine carrying container is fixedly mounted on the mounting part, the medicine carrying container is provided with a containing cavity for containing medicine, and an overflowing hole and a slow release hole which are communicated with the containing cavity are formed in the medicine carrying container; wherein a medicine control cavity with variable volume is arranged in the prosthesis body, the overflowing hole is communicated with the medicine control cavity, and the slow release hole is communicated with the outside of the prosthesis body. According to the technical scheme, the problem that in the prior art, due to long-time non-healing of bones, the bone fracture plate is broken or the artificial hip joint prosthesis is loosened is effectively solved, the medicine in the containing cavity can be one of anti-infection medicine, osteogenesis promoting medicine, anti-osteoporosis medicine and anti-tumor medicine, and therefore the medicine can be used for treating osteoporosis. A doctor can select according to the actual condition of a patient, so that the implanted prosthesis can provide help for corresponding treatment.

Belonging to the field of medical technology, the invention discloses a postoperative wound anti-infection drug and a preparation method thereof. The postoperative wound anti-infection drug is prepared from the following components by weight: 15-20 parts of an arundina graminifolia extract, 10-15 parts of mangnolia officinalis, 8-12 parts of phellodendron, 5-10 parts of peppermint oil, 2-5 parts of methyl violet, 5-8 parts of indigo naturalis, 16-19 parts of flaxseed oil, 8-11 parts of citric acid, and 35-42 parts of anhydrous ethanol. The anti-infection drug prepared according to the invention can effectively inhibit the production of bacterial toxin, reduce the postoperative wound infection rate, at the same time alleviate the wound pain, make the wound heal quickly, and reduce the generation of scars, and after being made into a spray, is convenient to preserve and carry, and is convenient to take.

The present invention relates to antibody engineering and anti-infection drug field, provides a method for detection and evaluation of biological functions of a molecule and a medicine and use thereof, and particularly relates to a method for detection of biological functions of (human) anti-human hepatitis B virus antibody. The method can effectively detect the level of the biological functions of the molecule, the medicine and the (human) anti-human hepatitis B virus antibody. According to the method, biological activity of a forerunner molecule and drug can be defined by detection of the ability of the to-be-detected forerunner molecule and drug to neutralize pathogene key molecules in animal body and the ability of the to-be-detected forerunner molecule and drug to break immune tolerance and reconstruct immune protection in the animal body. The method can be used for rapid detection of virus clearing ability and virus infection and pathogenesis control ability of antibodies and other anti-infection drugs. The method has the advantages of simple operation process and good the repeatability, and is a supplement to methods in the prior art for detection and evaluation of functionality of antiviral drugs, the method is established for providing a new choice for research and development of drugs of cell and animal infection model virus.

The invention belongs to the technical field of medicine and particular relates to a novel compound of an anti-infection drug and a preparation method thereof. According to the compound, characteristic peaks are displayed at diffraction angles of 3.5 degrees, 4.6 degrees, 8.4 degrees, 12.5 degrees, 13.8 degrees, 16.2 degrees, 19.0 degrees, 19.5 degrees, 20.0 degrees, 21.1 degrees, 27.1 degrees and 33.1 degrees in an X-ray powder diffraction pattern obtained through measurement by Cu-KAlpha rays. The invention further relates to powder injection containing 100% cefazedone sodium. The new crystal from of the compound is different from that in the prior art, through experimental verification, it is surprised to find that compared with the prior art, the powder injection obtained by direct subpackage of the compound of the novel crystal form does not need any auxiliary material and is good in liquidity, the content of impurities and moisture is reduced effectively, the safety of products is good, and the stability is high.

The invention discloses a 3-aryl-4-(2-acyloxy ethyoxyl)-2(5H)-furanone compound, which is shown as a structural formula in the specifications. The compound plays a role in suppressing staphylococcus epidermidis, klebsiella pneumonia, novel cryptococcus gattii and the like and can be used for preparing an anti-infection medicament for treating pneumonia, wound suppuration and the like. The invention also discloses a preparation method of the compound.

An implantable drug eluting medical device includes a polymer substrate having a surface, a first plurality of nanofibers, and at least one antimicrobial drug. Each of the first plurality of nanofibers includes a first portion interpenetrated with the surface of the substrate to mechanically fix the nanofiber to the substrate, and a second portion projecting from the surface. The at least one antimicrobial drug is disposed within or among the second portion of the first plurality of nanofibers.

Oxazolidinone-adenosine type compounds have the following structural general formula described in the specification; the compounds have better inhibition and killing effects on various pathogenic bacteria; a part of compounds have higher bacteriostatic activity than penicillin G, kalamycin, ketoconazole and linezolid and can be used for preparation of anti-infection drugs; the invention discloses a preparation method and a biological activity of the compounds.

The invention discloses 4'-N-demethyl-vicenistatin as well as a preparation method and application thereof, and belongs to the technical field of natural products. According to the present invention, the N-demethylation vicenatistatin derivative 4'-N-demethylation-vicenistatin is separated from the N-methyltransferase inactivated mutant strain SCSIO Mla-L010 / [delta] vicG of S.parvus SCSIO Mla-L010, the test result shows that the 4'-N-demethylation-vicenistatin has significant inhibitory activity on a variety of fungi and bacteria, the important value of the 4'-N-demethylation-vicenistatin in the development of anti-infection drugs is displayed, the antibacterial activity of the 4'-N-demethylation-vicenistatin on fungi Candida albicans is 2-4 times stronger than the antibacterial activity of vicenistatin on fungi Candida albicans, and the derivative with the structure has better patent medicine potential. In addition, the 4'-N-demethyl-vicenistatin also shows relatively strong cytotoxic activity on a plurality of cancer cells, and has the potential of being developed into an anti-tumor drug.

The invention provides a compound polysaccharide immunological enhancement agent for pets and a preparation method and application thereof. The enhancement agent is prepared from bursa fabricius bioactive peptide BP-IV, mannan oligosaccharide, vitamin A, adhesive, disintegrant and lubricant. The enhancement agent has a good immunological enhancement effect on the pets, the capacity for the organisms to resist pathogen infection can be enhanced, and the health level of the organisms is improved. Compared with existing anti-infection medicine, the enhancement agent is a good pet compound for enhancing immunity, can be used for clinically preventing infectious diseases, and has high application value in improving the immunological capacity of the organisms of the pets.

The invention belongs to the technical field of medicine and particular relates to a novel compound of an anti-infection drug and a preparation method thereof. According to the compound, characteristic peaks are displayed at diffraction angles of 3.5 degrees, 4.6 degrees, 8.4 degrees, 12.5 degrees, 13.8 degrees, 16.2 degrees, 19.0 degrees, 19.5 degrees, 20.0 degrees, 21.1 degrees, 27.1 degrees and 33.1 degrees in an X-ray powder diffraction pattern obtained through measurement by Cu-KAlpha rays. The invention further relates to powder injection containing 100% cefazedone sodium. The new crystal from of the compound is different from that in the prior art, through experimental verification, it is surprised to find that compared with the prior art, the powder injection obtained by direct subpackage of the compound of the novel crystal form does not need any auxiliary material and is good in liquidity, the content of impurities and moisture is reduced effectively, the safety of products is good, and the stability is high.

The invention relates to an anti-infection coating capable of realizing immediate construction in an operation as well as a preparation method and application of the anti-infection coating. The anti-infection coating comprises an anti-infection drug coating covering the surface of a main body structure and a high polymer material coating covering the surface of the anti-infection drug coating, and the high polymer material comprises chitosan and beta-sodium glycerophosphate. The temperature-sensitive phase-change high polymer material coating can be subjected to rapid phase change under a heating condition, and the surface of the main body structure is covered with an anti-infection drug, so that immediate construction in an operation is realized, the defect that in the prior art, an antibacterial coating needs to be prepared before the operation, and then the storage problem needs to be considered is overcome. Meanwhile, the content of the anti-infection drug can be adjusted according to the infection degree of the focus in the operation, and personalized treatment is achieved. Meanwhile, the biocompatibility of the anti-infection coating is good, the local slow release behavior of the anti-infection drug can be achieved, and the action time of the drug is remarkably prolonged.

The present invention belongs to the technical field of suspending agent solutions of veterinary anti-infection drugs and preparation methods thereof, particularly to a suspending agent containing amfomycin calcium, hydrocortisone and kanamycin sulfate, and a preparation method thereof. The formulation comprises (a) bulk drugs amfomycin calcium, hydrocortisone and kanamycin sulfate, (b) an assistant suspending agent, (c) a wetting agent, (d) a preservative, and (e) a preservative. The suspending agent containing amfomycin calcium, hydrocortisone and kanamycin sulfate is prepared by adopting the dispersion method, is the white-like and slightly-viscous water suspension, has characteristics of good stability, good palatability, long elimination half life and high bioavailability, and can be used as the veterinary oral formulation.