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Nano-silver emulsifiable paste and its preparation method

A nano-silver, cream technology, applied in the field of medicine, can solve the problems of increasing medical costs, shortage of medical resources, heavy economic burden on patients and families, etc., to restore the health of the wounded, reduce combat attrition, and promote wound healing.

Inactive Publication Date: 2012-10-17
中国人民解放军济南军区第四零一医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The problem of bacterial drug resistance is becoming more and more serious. It not only makes the patient's condition difficult to cure for a long time, brings great physical and mental pain and heavy economic burden to the patient and family, but also increases the medical cost of the whole society, making limited medical resources more scarce
Antibiotics without the problem of bacterial resistance have not been reported

Method used

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  • Nano-silver emulsifiable paste and its preparation method
  • Nano-silver emulsifiable paste and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Components and content of nano silver cream: 59.1g stearic acid, 59.1g stearyl alcohol, 118.2g liquid paraffin, 0.5g ethylparaben, 4.6g triethanolamine, 10.1g laurocaprolactone, 2,6- Di-tert-butyl-p-cresol 0.5g, edetate disodium 0.5g, glycerin 228g, nano-silver solution 232.6mL, add water to 1000g.

[0040] Preparation:

[0041] (1) Preparation of water phase: Add glycerin, disodium edetate and ethylparaben into an appropriate amount of nano-silver solution, heat to 80°C, stir well, and set aside.

[0042] (2) Oil phase preparation: Mix stearic acid, stearyl alcohol, 2,6-di-tert-butyl-p-cresol, laurocaprazine and liquid paraffin, heat to 75°C, and stir well.

[0043] (3) Immediately add the water phase to the oil phase, then add triethanolamine, stop heating, stir rapidly immediately, and when the temperature drops to 50°C, continue stirring until it coagulates to obtain nano silver cream.

Embodiment 2

[0045] Components and content of nano silver cream: 59.1 g of stearic acid, 59.1 g of stearyl alcohol, 118.2 g of liquid paraffin, 4.6 g of triethanolamine, 228 g of glycerin, 200 mL of nano silver liquid, and add water to 1000 g.

[0046] Preparation:

[0047] (1) Preparation of water phase: Mix glycerin and nano-silver solution, heat to 80°C, stir well, and set aside.

[0048] (2) Preparation of oil phase: Mix stearic acid, stearyl alcohol and liquid paraffin, heat to 75°C, stir well, and set aside.

[0049] (3) Immediately add the water phase to the oil phase, then add triethanolamine, stop heating, stir rapidly immediately, and when the temperature drops to 50°C, continue stirring until it coagulates to obtain nano silver cream.

Embodiment 3

[0051] Components and content of nano silver cream: 59.1g stearic acid, 59.1g stearyl alcohol, 118.2g liquid paraffin, 4.6g triethanolamine, 10.1g laurocapram, 2,6-di-tert-butyl p-cresol 0.5g, 0.5g disodium edetate, 228g glycerin, 300mL nano-silver solution, add water to 1000g.

[0052] Preparation:

[0053] (1) Preparation of water phase: Mix glycerin, disodium ethylenediaminetetraacetic acid, and nano-silver solution, heat to 80°C, stir well, and set aside.

[0054] (2) Oil phase preparation: Mix stearic acid, stearyl alcohol, 2,6-di-tert-butyl-p-cresol, laurocaprazine and liquid paraffin, heat to 75°C, stir well, and set aside.

[0055] (3) Immediately add the water phase to the oil phase, then add triethanolamine, stop heating, stir rapidly immediately, and when the temperature drops to 50°C, continue stirring until it coagulates to obtain nano silver cream.

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Abstract

The invention provides a nano-silver emulsifiable paste and its preparation method and relates to the field of medicines. The nano-silver emulsifiable paste is an O / W type emulsifiable paste or W / O type emulsifiable paste which is prepared by a certain preparation technology with nano-silver being used as a main drug. The nano-silver emulsifiable paste can be used for treating infection of infected wounds and body surface chronic ulcer (venous ulcer, pressure ulcer and the like) caused by burn and scald and physical and mechanical damage and for promoting healing of the wounds. The O / W type emulsifiable paste is similar to a moistening burn cream and can provide burn and scald wounds with a moistening environment which is beneficial to tissue regeneration. Simultaneously, due to specific high antibacterial activity and good wound heating promotion effect of the nano-silver, the nano-silver emulsifiable paste is better than the moistening burn cream; and in comparison with sulfadiazine silver and other external-use anti-infection drugs, the nano-silver emulsifiable paste is beneficial to wound healing, has no bacterial drug resistance and has high antibacterial activity.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a nano-silver cream and a preparation method thereof. Background technique [0002] Burns and other traumas caused by other reasons are relatively common clinically, especially during wartime. External use of anti-infective drugs to prevent the deepening of wound bacterial invasion is the initial and important part of the whole treatment process. The commonly used drug at present is silver sulfadiazine. After a long period of application, it is found that the drug has side effects of deepening the wound surface and delaying healing, and the drug-resistant bacteria of the drug have been found clinically. [0003] The problem of bacterial drug resistance is becoming more and more serious. It not only makes the patient's condition difficult to cure for a long time, brings great physical and mental pain and heavy economic burden to the patient and family, but also increases the medical cost o...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K33/38A61K47/44A61P17/02
Inventor 马守栋李明春曹恩惠赵丽艳
Owner 中国人民解放军济南军区第四零一医院
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