Anti-infection and anticoagulation coating for central venous catheters and preparation method thereof

Abstract

The invention relates to an anti-infection and anticoagulation coating for central venous catheters and a preparation method thereof. The anti-infection and anticoagulation coating comprises the following raw materials in percentage by weight: 0.81-2.0% of support polymer, 1.2-2.8% of super-lubrication hydrophilic polymer, 0.32-1.0% of anti-infection drug, 0.1-1.5% of coupling agent, and 90-97% of water. The anti-infection and anticoagulation coating has the advantages that the anti-infection and anticoagulation double functions are realized; the coating technology is simple, the effect is obvious, and the application range is wide.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to an anti-infection and anti-coagulation coating for a central venous catheter and a preparation method thereof. Background technique [0002] At present, the most widely used anti-infection central venous catheters in the world are the Arrow series products developed and produced by the American Teleflex Company, which use the swelling properties of the polyurethane material on the surface of the catheter to absorb antibacterial substances widely used in clinical practice to achieve the antibacterial performance of the catheter itself, but There is no anticoagulant effect. The Vantex series of anticoagulant and anti-infection central venous catheters produced by Edwards of the United States use polyurethane-based OLIGON polymers (including: silver, platinum, and black carbon), and AMC thrombosis protection is attached to the surface. The product uses silver-pla...

AI Technical Summary

Problems solved by technology

[0002] At present, the most widely used anti-infection central venous catheters in the world are the Arrow series products developed and produced by the American Teleflex Company, which use the swelling properties of the polyurethane material on the surface of the catheter to absorb antibacterial substances widely used in clinical practice to achieve the antibacterial performance of the catheter itself, but There is no anticoagulant effect. The Vantex series of anticoagulant and anti-infection central venous catheters produced by Edwards of the United States use polyurethane-based OLIGON polymers (including: silver, platinum, and black carbon), and AMC thrombosis protection is attached to the surface. The product uses silver-platinum carbon to form a micro-battery, and slowly forms silver ions with strong bactericidal properties under the spontaneous electro-chemical reaction to achieve anti-infection effects. However, the current silver-ion products will gradually be eliminated. Self-patented technology provides the platform with a super-lubricating medical coating, which can reduce the adhesion of blood cells and microorganisms on the surface of the tube body, but it does not have the effect of anti-infection and anti-coagulation in the true sense

[0003] The wide clinical use of central venous catheters is the basis for product development. All related products with anti-infection properties on the market are imported, and no products have dual properties of anti-coagulation and anti-infection. Domestic research on the surface modification technology of central venous catheters has achieved There are quite a few, and a large number of research results have been published in journal patent reports, but there are still no products with anticoagulant and anti-infective properties in the true sense, and the market is basically in a blank stage. Strong will, such products are urgently needed to improve the medical level and reduce the risk of surgery