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Absorbable anti-adhesion hernia repairing patch and preparation method thereof

A hernia repair and anti-adhesion technology, applied in medical science, prosthesis, etc., can solve problems such as increased patient pain, multiple complications, adhesion, etc., to reduce patient pain, high tension, abdominal compliance, and tissue compatibility. good effect

Inactive Publication Date: 2017-01-25
武汉蓝普医品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide an absorbable and anti-adhesion hernia repair sheet and its preparation method to solve the technical problems of the existing hernia repair sheet that will adhere to viscera after the hernia repair operation, cause various complications, and increase the suffering of patients.

Method used

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  • Absorbable anti-adhesion hernia repairing patch and preparation method thereof
  • Absorbable anti-adhesion hernia repairing patch and preparation method thereof

Examples

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Effect test

Embodiment 1

[0032] A method for preparing an absorbable anti-adhesion hernia repair sheet, comprising the following steps:

[0033] S1. The anti-infective drug Clinfloxacin and water are made into an aqueous solution of Clinfloxacin in a weight ratio of 1:2, and the aqueous solution of Clinfloxacin is added to the aqueous solution of the slow-release agent chitosan, mixed by stirring, and the drug is wrapped by the slow-release agent, Prepare slow-release anti-infective drug, the drug content of slow-release anti-infective drug is 50mg / ml;

[0034] S2. Spray the slow-release anti-infection drug on the lower mesh of polycarboxyacetic acid material, and form a ring-shaped slow-release anti-infection layer after drying;

[0035] S3. Use absorbable thread to sew the bottom of the lower mesh and the arc-shaped connector made of polycarboxyacetic acid;

[0036] S4. Use non-absorbable thread to suture the edge of the arc-shaped connecting body and the upper mesh sheet made of polypropylene to p...

Embodiment 2

[0038] A method for preparing an absorbable anti-adhesion hernia repair sheet, comprising the following steps:

[0039] S1. The anti-infective drug vancomycin and water are made into an aqueous solution of vancomycin in a weight ratio of 1:2, and the aqueous solution of vancomycin is added to the organosol of the slow-release agent polyethylene glycol, and the drug is mixed by stirring. Sustained-release agent package, prepared slow-release anti-infective medicine, the drug content of slow-release anti-infective medicine is 65mg / ml;

[0040] S2. Spray the slow-release anti-infection drug on the lower mesh made of polylactic acid, and form a ring-shaped slow-release anti-infection layer after drying;

[0041] S3. Use absorbable thread to suture the bottom of the lower mesh and the arc-shaped connector made of polycarboxyacetic acid;

[0042] S4. Use non-absorbable thread to suture the edge of the arc-shaped connecting body and the upper mesh sheet made of polypropylene to prep...

Embodiment 3

[0044] A method for preparing an absorbable anti-adhesion hernia repair sheet, comprising the following steps:

[0045] S1. The anti-infective drug neomycin and water are made into a neomycin aqueous solution in a weight ratio of 1:3, and the neomycin aqueous solution is added to the organic sol of the slow-release agent polylactic acid, and the drug is slowly released by stirring and mixing Agent package, prepared slow-release anti-infective drug, the drug content of slow-release anti-infective drug is 80mg / ml;

[0046] S2. Spray the slow-release anti-infection drug on the lower layer mesh made of polylactic-glycolic acid, and form a ring-shaped slow-release anti-infection layer after drying;

[0047]S3. Use absorbable thread to suture the bottom of the lower mesh and the arc-shaped connector made of polylactic-glycolic acid;

[0048] S4. The edge of the curved connecting body and the upper mesh made of polypropylene are sutured with a non-absorbable thread to obtain an abso...

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Abstract

The invention discloses an absorbable anti-adhesion hernia repairing patch and a preparation method thereof. The repairing patch comprises an upper-layer mesh and a lower-layer mesh, an arc-shaped connecting body is arranged between the upper-layer mesh and the lower-layer mesh, the edge of the arc-shaped connecting body is connected with the upper-layer mesh through non-absorbable lines, and the bottom of the arc-shaped connecting body is connected with the lower-layer mesh through absorbable lines; the lower-layer mesh and the arc-shaped connecting body are both made from an absorbable material; the lower-layer mesh is provided with multiple slow-release anti-infection layers which are distributed in a concentric annulus mode, and the circle center of the concentric annulus coincides with the center of the lower-layer mesh; the slow-release anti-infection layers are formed by applying slow-release anti-infection drugs on the lower-layer mesh and then drying the drugs at normal temperature. The arc-shaped connecting body and the lower-layer mesh are both made from the biodegradable material, can be slowly metabolized in a human body, is nontoxic and harmless and can effectively isolate the wound surface from visceral organs, the condition that the wound surface directly makes contact with the peripheral tissues in the healing process is avoided, and adhesion is effectively prevented.

Description

technical field [0001] The invention relates to a hernia repair sheet, in particular to an absorbable anti-adhesion hernia repair sheet and a preparation method thereof. Background technique [0002] Abdominal wall hernia is caused by the protrusion of abdominal viscera through the femoral inguinal canal. The incidence of abdominal wall hernia is high (about 27% for men and about 3% for women), and it may occur at various ages. Traditional repair methods are easy to Recurrence, long repair time, postoperative pain, etc. are determined and not adopted, and tension-free repair surgery using mesh methods emerged as the times require. Tension-free hernia repair surgery uses a mesh to repair the hernia gap, which avoids the disadvantages of postoperative pain and easy recurrence of traditional hernia repair surgery. At present, patches made of polyester and polypropylene materials are commonly used clinically. [0003] Polypropylene patch has excellent chemical stability and ti...

Claims

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Application Information

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IPC IPC(8): A61F2/00A61L27/16A61L27/18A61L27/54A61L27/58
Inventor 沈传宝李先华李辉沈乔
Owner 武汉蓝普医品有限公司
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