The invention discloses fibronectin essence lotion having high permeability and capable of reproducing photosensitive nascent skin and a preparation method of the fibronectin essence lotion. The fibronectin essence lotion comprises 45.0-70.0 parts of group A raw materials, 3.0-6.0 parts of group B raw materials, 10.0-20.0 parts of group C raw materials, 0.3-1.0 part of group D raw materials, 2.0-6.0 parts of group E raw materials and 15.0-30.0 parts of group F raw materials. The fibronectin essence lotion has the beneficial effects that efficient active ingredients such as thiamine HCl, riboflavin, nicotinamide, pantothenic acid, pyridoxine, folic acid, cyanocobalamin vitamin B family compounds, fibronectin, acetyl hexapeptide-8, asiaticoside, saccharide isomers, brown algae extracts, phytosterol low-erucic-acid rapeseed oil glycerides, glyceryl glucoside, laurocapram and the like are selected, the lotion can realize efficient permeation, and skin moisture is locked. The skin barrier and sensitivity are deeply repaired, vitamins and energy necessary for the skin are supplemented, the health state is recovered, and the photosensitive nascent skin is reproduced.