Suspending agent containing amfomycin calcium, hydrocortisone and kanamycin sulfate, and preparation method thereof

A technology of kanamycin sulfate and hydrocortisone, which is applied in the field of preparation of suspensions, can solve the problems that cartilage tissue cannot be repaired by itself, and chondrocytes are too late to produce enough

Inactive Publication Date: 2015-02-11
QINGDAO KDN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cartilage repairs after wear and tear, but chondrocytes do not have time to produce a sufficient spongy matrix, so worn cartilage cannot repair itself

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example

[0023] Example: 5% amphomycin calcium + hydrocortisone + kanamycin sulfate aqueous suspension

[0024] [Prescription] Amphomycin Calcium + Hydrocortisone + Kanamycin Sulfate 5+15% (W / V)

[0025] Tragacanth Gum 0.8%(W / V)

[0026] Propylene Glycol 10%(W / V)

[0027] Poloxamer 0.3%(W / V)

[0028] Sodium Benzoate 0.2%(W / V)

[0029] Add pure water to 100% (V / V)

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PUM

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Abstract

The present invention belongs to the technical field of suspending agent solutions of veterinary anti-infection drugs and preparation methods thereof, particularly to a suspending agent containing amfomycin calcium, hydrocortisone and kanamycin sulfate, and a preparation method thereof. The formulation comprises (a) bulk drugs amfomycin calcium, hydrocortisone and kanamycin sulfate, (b) an assistant suspending agent, (c) a wetting agent, (d) a preservative, and (e) a preservative. The suspending agent containing amfomycin calcium, hydrocortisone and kanamycin sulfate is prepared by adopting the dispersion method, is the white-like and slightly-viscous water suspension, has characteristics of good stability, good palatability, long elimination half life and high bioavailability, and can be used as the veterinary oral formulation.

Description

technical field [0001] The invention belongs to the technical field of veterinary anti-infectives and preparation methods, and in particular relates to a preparation method of a suspending agent of amphomycin calcium+hydrocortisone+kanamycin sulfate. [0002] technical background [0003] Normal articular cartilage is white, smooth and translucent. It is composed of chondrocytes and a spongy matrix surrounding chondrocytes. The main components of this matrix are collagen, polysaccharide protein and water. In the early stage of osteoarthritis, the cartilage will appear yellow and opaque, and some parts of the surface will soften and become rough. [0004] As the disease progresses, this softened cartilage cracks and wears away, exposing the underlying hard bone. At the same time, the changed cartilage reorganizes and increases in stiffness, and the remaining cartilage begins to wear away. Eventually, osteophytes form in the joints. Cartilage repairs after wear and tear, b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K9/10A61P31/00A61P29/00A61P19/02A61K31/7036A61K31/573
Inventor 张瑞丽郝智慧
Owner QINGDAO KDN BIOTECH
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