Method for detection and evaluation of biological functions of molecule and medicine and use thereof
A molecular and drug technology, applied in the direction of medical preparations containing active ingredients, drug combinations, and pharmaceutical formulas, can solve the problems of lagging application of HBV transgenic mice, and achieve the effect of simple operation and good repeatability of results
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[0044] Example 1: Ability of anti-HBV monoclonal antibody and HBIG to neutralize HbSAg in animals
[0045] Using the detection method established in the present invention, respectively detect the ability of anti-HBV monoclonal antibody and HBIG to neutralize HbSAg in animal body. HBIG is a human anti-hepatitis B virus globulin produced by Zhongsheng Group. The humanized anti-HBV monoclonal antibody was provided by the Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention.
[0046] The specific detection steps are:
[0047] (1) 7-8 week-old female C57BL / 6J-Tg(AlblHBV)44Bri / Jf4J mice stably expressing HbSAg were selected for the experiment.
[0048] (2) After grouping, 0.5 ml of experimental samples were injected intraperitoneally.
[0049] (3) Blood was collected from the venous plexus of the mouse frame at a specific time point. After the blood sample was allowed to stand at room temperature for 1 hour, it was centrifuged at a ...
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