20 results about "Isopropyl ether" patented technology

The invention relates to the technical field of pharmaceutical chemical engineering, in particular to a preparation method of a 5-fluoro-1-(2-fluorophenyl)-1H-pyrazolone [3, 4-B] pyridine-3-formonitrile crystal form, which comprises the following steps: mixing a 5-fluoro-1-(2-fluorophenyl)-1H-pyrazolone [3, 4-B] pyridine-3-formonitrile solid with isopropyl ether, and stirring for dissolving; and cooling, growing crystals, performing suction filtration, washing and drying. The preparation method of the 5-fluoro-1-(2-fluorophenyl)-1H-pyrazolone [3, 4-B] pyridine-3-formonitrile crystal form solves the problems that the original crystal form of the existing 5-fluoro-1-(2-fluorophenyl)-1H-pyrazolone [3, 4-B] pyridine-3-formonitrile is small in density, large in volume and easy to generate electrostatic effect, and the crystal form is easy to agglomerate to wrap impurities and is not beneficial to subsequent API (American Petroleum Institute) purification.

The present application relates to the technical field of medicine and chemical industry, and in particular to a preparation method of a 5-fluoro-1-(2-fluorophenyl)-1H-pyrazolyl[3,4-B]pyridine-3-carbonitrile crystal form, which comprises the following steps: mixing 5-fluoro-1-(2-fluorophenyl)-1H-pyrazolyl[3,4-B]pyridine-3-carbonitrile solid with isopropyl ether, and then stirring and dissolving; cooling and crystallizing, and then drying after filtration and washing to obtain the product. The preparation method of the 5-fluoro-1-(2-fluorophenyl)-1H-pyrazolyl[3,4-B]pyridine-3-carbonitrile crystal form solves the problems of the original crystal form of 5-fluoro-1-(2-fluorophenyl)-1H-pyrazolyl[3,4-B]pyridine-3-carbonitrile, such as small density, large volume and easy electrostatic effect, and the crystal form is easy to form a group and wrap impurities, which is not conducive to subsequent API purification.

The invention belongs to the technical field of reverse osmosis membranes, and discloses a preparation method of a hyperconcentration SD reverse osmosis membrane and the hyperconcentration SD reverse osmosis membrane. The preparation method comprises the following steps: (1) adding a polymer into an organic solvent in a heating and stirring state to obtain a mixed solution; (2) cooling the mixed solution, and continuously adding a pore-foaming agent to obtain a precursor solution; (3) performing vacuum defoaming treatment on the precursor solution to obtain a membrane casting solution; (4) loading the membrane casting solution on a carrier, and then carrying out gel bath treatment to obtain a base membrane; and (5) sequentially infiltrating the base membrane in a water phase solution and an organic phase solution to perform polyamide treatment, thereby obtaining the super-concentrated SD reverse osmosis membrane. Wherein the water phase solution is prepared from m-phenylenediamine and piperazine; the organic phase solution comprises a first component and a second component, the first component comprises trimesoyl chloride, and the second component comprises at least one of xylene, acetone, isopropyl ether, ethyl acetate and paraphthaloyl chloride.

The invention provides a device and a method for reducing the COD (Chemical Oxygen Demand) content of wastewater of an epoxypropane device. The treatment method comprises the following steps: carrying out negative pressure cyclone separation on flashed saponification wastewater to obtain a first gas phase and a first liquid phase; condensing the first gas phase to obtain a second gas phase and a second liquid phase; carrying out gas-liquid separation on the second gas phase to obtain an oil phase and a third gas phase; and mixing the second liquid phase and the oil phase, standing and separating to obtain dichloro isopropyl ether and a water phase. The COD (Chemical Oxygen Demand) content and the dichloro isopropyl ether content of the treated saponified wastewater are reduced.

The invention relates to a method for synthesizing polymeric dyes by polymerizing polymerizable monomers bearing polymerizable functional groups (e.g., acrylates, methacrylates, acrylamides or methacrylamides) and chromophore functional groups, in which the polymerization is carried out in a solvent selected from a mixture of methyl ethyl ketone and ethanol or acetonitrile, and the purification of the resulting polymeric dye is carried out with a solvent selected from the group consisting of diisopropyl ether, methyl tert-butyl ether, dimethyl carbonate, ethyl acetate and water. The invention also relates to the resulting polymeric dyes and to ink compositions comprising same. In particular, the following polymeric dyes are disclosed:.

This application discloses a method for preparing diisopropyl ether from propylene hydration. A raw material containing propylene and water is contacted with a catalyst and reacted to obtain a product containing diisopropyl ether. The catalyst consists of a support and an active component supported on the surface of the support; the support is an Hβ molecular sieve; the active component is selected from at least one of CuO, Fe2O3, and CoO. The reaction is fast, with high yield, and can be applied to large-scale production. The catalyst preparation method is stable, controllable, and reproducible.

The present application relates to the technical field of separation and purification of Schizonepeta tenuifolia, and is a kind of Schizonepeta tenuifolia phenylpropanoid compound, its preparation method and application, Schizonepeta tenuifolia is extracted by heating reflux with ethanol solution and recovered under reduced pressure, and concentrated, the total extract of Schizonepeta tenuifolia is extracted and concentrated with petroleum ether, dichloromethane and ethyl acetate in turn, the extract of ethyl acetate part is separated by gradient elution, the third fraction is separated by gradient elution, the first fraction is separated by gradient elution, the sixth fraction is separated by gradient elution, and phenylpropanoid compound one and phenylpropanoid compound two are obtained at 12.1 minutes and 13.4 minutes, respectively. The present application discloses phenylpropanoid compound one and phenylpropanoid compound two separated from Schizonepeta tenuifolia for the first time, and in vitro anti-inflammatory pharmacodynamic experiments are carried out on the two compounds, which prove that they have a certain inhibitory effect on RAW264.7 cells, and can be applied to the preparation of anti-inflammatory drugs.

The invention discloses a synthesis method for preparing an aryl phosphine-oxazoline ligand, which comprises the following steps: sequentially adding an alkyl alcohol alkali metal compound, a first solvent and a compound B into a reaction container, stirring, continuously adding a compound A, carrying out heat preservation reaction at the reaction temperature of 0-100 DEG C, and synthesizing the aryl phosphine-oxazoline ligand by a one-pot method, the alkyl alcohol alkali metal compound is selected from potassium tert-butoxide, sodium tert-butoxide, lithium tert-butoxide, potassium isopropoxide, sodium isopropoxide, lithium isopropoxide, sodium ethoxide and sodium methoxide; the first solvent is selected from the group consisting of tetrahydrofuran, diethyl ether, 1, 4-dioxane, 2-methyltetrahydrofuran, ethylene glycol dimethyl ether, cyclopentyl methyl ether, methyl tert-butyl ether and isopropyl ether. The method has the advantages of few reaction steps, easily available raw materials, mild reaction conditions, high yield, simple separation and convenient purification.

The invention discloses a method for accurately detecting impurity metal elements in high-purity gallium. The method comprises the following steps: completely dissolving high-purity gallium in mixed acid, adding ammonia water, standing, and fully precipitating; taking out supernate obtained by standing and precipitating, adding the mixed acid again, fully mixing, and concentrating to obtain a to-be-detected precursor; adding ultrapure water and an internal standard substance into the to-be-detected precursor, uniformly mixing to obtain a to-be-detected sample, and detecting by ICP-MS (Inductively Coupled Plasma Mass Spectrometry) to obtain the target product. According to the method, a solvent-precipitation separation-detection process is constructed through the synergistic effect of all the steps, the problem that the detection result is inaccurate due to impurities introduced by isopropyl ether is effectively avoided, and the method does not need to adopt a GD-MS or a customized chlorination separation device, so that the detection cost is greatly reduced, and the detection precision is effectively ensured.

The invention relates to the technical field of synthesis of pesticide intermediates, in particular to an industrial production process of 2, 4-dichloro-5-nitrophenyl isopropyl ether, which comprises the following steps: reacting 2, 4-dichloro-5-nitrophenol with caustic soda liquid to generate sodium salt by taking methylbenzene as a solvent, then carrying out azeotropic dehydration, and directly adding a catalyst to carry out etherification reaction with isobromopropane to obtain 2, 4-dichloro-5-nitrophenyl isopropyl ether. The catalyst is 2, 4-dichloro-5-nitrophenyl isopropyl ether. The method realizes the recycling of isobromopropane and the recovery of the byproduct bromine salt, reduces the production cost, is more environment-friendly, is short in reaction time, and is suitable for industrial large-scale production.

According to the method for treating the lithium precipitation mother liquor based on eutectic solvent extraction-precipitation, trioctylphosphine oxide and tetradecyl phosphoric acid are mixed to form a eutectic solvent system, trioctylphosphine oxide serves as a hydrogen bond acceptor, and the property of an eutectic solvent extraction-precipitation agent is regulated and controlled. Compared with an extraction-precipitation strategy of single tetradecyl phosphoric acid, by introducing trioctylphosphine oxide, the particle size of the precipitate is remarkably increased, an organic solvent is prevented from being used in the reverse extraction process, and meanwhile, the high-selectivity precipitation capacity of tetradecyl phosphoric acid TDPA to lithium is kept. The lithium can be enriched without isopropyl ether in the reverse extraction process, so that the isopropyl ether evaporation process in the extraction-precipitant circulation process is reduced, the overall energy consumption is reduced, and meanwhile, the performance attenuation of the extraction-precipitant caused by isopropyl ether oxidation is also avoided.

This invention discloses an esomeprazole sodium and its purification method, relating to the field of drug synthesis technology. The purification method includes the following steps: S1, mechanically grinding crude esomeprazole sodium with a composite solid purification additive to obtain an activated mixture; the composite solid purification additive is a composition of diisopropyl tartrate and hydroxypropyl-β-cyclodextrin, and the mass ratio of diisopropyl tartrate to hydroxypropyl-β-cyclodextrin is (1~5):(2~4); S2, adding a washing solvent to the activated mixture and stirring and washing, then performing solid-liquid separation to obtain a solid wet product; the washing solvent includes ethyl acetate, methyl tert-butyl ether, or isopropyl ether; S3, drying the solid wet product to obtain purified esomeprazole sodium. This purification method is not only simple in process and has a high product yield, but also does not introduce new impurities, and the product has high optical and chemical purity.

Method for manufacturing a cathode of a lithium-sulfur secondary battery, comprising: (1) Production of a primary sludge by mixing sulfur, a conductive material, a first solvent and a non-aqueous planar contact binder, (2) Production of a primary composite material by drying the primary sludge and pulverizing the primary sludge, (3) Producing a secondary slurry by mixing the primary composite, the conductive material and a second solvent with an aqueous point contact binder, and (4) Applying the secondary sludge to a cathode plate, wherein the first solvent is one or more selected from the group consisting of N-methylpyrrolidone, acetonitrile, isopropyl ether, benzene, chloroform, n-hexane, methanol, acetone, and toluene, and the non-aqueous planar contact binder is one or more from the group consisting of polyvinyl acetate, polyvinyl alcohol, polyethylene oxide, polyvinylpyrrolidone, polyvinyl ether, polymethyl methacrylate, polyvinylidene fluoride, polyhexafluoropropylene-polyvinylidene fluoride copolymer, polyethyl acrylate, polytetrafluoroethylene, polyvinyl chloride, polyacrylonitrile, carboxymethylcellulose (CMC), and combinations thereof, wherein the second solvent of step (3) is water, and the aqueous point contact binder is one or more selected from the group consisting of polyvinylpyrrolidone, polytetrafluoroethylene, styrene-butadiene rubber (SBR), carboxymethylcellulose (CMC), and combinations thereof, and wherein the secondary sludge is produced by dispersing the primary composite material using ultrasonic waves and mixing it with the conductive material, the second solvent and the aqueous point contact binder.

The ink-jet ink of the present invention comprises a solvent S having an SP value of 9.1-9.4, resin emulsion particles and water. It is preferable that the resin emulsion particles contain a (meth)acrylic polymer. It is also preferable that the resin emulsion particles contain a structural unit derived from styrene. It is also preferable that the solvent S is tripropylene glycol monomethyl ether and / or monoethylene glycol monoisopropyl ether.

The application discloses a production method of preparing tetrabutyl tin with single solvent, and particularly relates to the technical field of organic compound synthesis. The application solves the technical problems of large solvent loss, high energy consumption of separation, complex water removal process and low product yield in the traditional THF and toluene mixed solvent process. In the application, isopropyl ether is used as single solvent, magnesium and chlorobutane are used to generate butylmagnesium chloride in the isopropyl ether; then, tin tetrachloride is dropped into the mixture, and tetrabutyl tin and anhydrous magnesium chloride are generated by continuous stirring reaction; hydrochloric acid is added to the system to dissolve the solid precipitate, and the upper organic phase is obtained by standing and separating; finally, the isopropyl ether is recovered by normal pressure distillation, and the tetrabutyl tin is obtained by reduced pressure distillation. The application realizes efficient recovery and recycling of the solvent by using the low boiling point and water insolubility of the isopropyl ether; and the molecular sieve drying step is omitted by using the in-situ water absorption property of the by-product anhydrous magnesium chloride.

This invention belongs to the field of catalyst technology and discloses a modified clay mesoporous composite catalyst, its preparation method, and its application. The preparation method includes: (1) crystallizing a mesoporous silica precursor solution containing a template agent, a silicon source, and a pore-expanding agent to obtain a mesoporous silica filter cake; (2) mixing the mesoporous silica filter cake, clay minerals, and a first dispersant to obtain a clay mesoporous composite slurry; then, selectively diluting the clay mesoporous composite slurry and drying it to obtain a clay mesoporous composite material; (3) mixing the clay mesoporous composite material with an acid solution to obtain a modified clay mesoporous composite catalyst. The catalyst provided by this invention can achieve a stable conversion of isopropanol to isopropyl ether with high conversion rate and high selectivity.

The invention provides an adamantane carbonate derived photoacid generator and a preparation method thereof.The method comprises the steps that triphosgene serves as a substrate, the triphosgene, adamantane methanol and organic alkali are dissolved in an organic solvent, after substitution reaction is conducted under the temperature control condition, reaction liquid is filtered and subjected to reduced pressure distillation, and a chloroformate adamantane methyl ester intermediate is obtained; the preparation method comprises the following steps: reacting an intermediate with 2-fluoro-2-bromoethanol and organic alkali in dichloromethane at a controlled temperature to obtain 1-adamantane methyl carbonate 2-bromo-2-fluoroethyl ester oily matter, sulfonating the oily matter to obtain a 1-adamantane methyl carbonate 2-fluoroethyl ester sodium sulfonate carbonate compound, and reacting the compound with 4-[1-(4-methoxybenzoyl)-2, 2, 4-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3 The preparation method comprises the following steps: carrying out anion exchange reaction on 2, 2-dimethylpropyl]-[1, 4] oxathietidine-4-onium trifluoroacetate in a mixed system of dichloromethane and water, concentrating an organic phase, and finally crystallizing isopropyl ether to obtain a target product.

The invention relates to the technical field of isopropyl alcohol dehydration catalyst preparation, and discloses a spherical clay mesoporous composite material catalyst, a preparation method thereof and an application in isopropyl ether preparation through isopropyl alcohol dehydration, the catalyst comprises a carrier and clay mineral loaded on the carrier, the carrier is spherical mesoporous silica, and the clay mineral is loaded on the carrier. On the basis of the total weight of the catalyst, the content of the clay mineral is 1-40 wt%. When the spherical clay mesoporous composite material catalyst is applied to an isopropanol dehydration reaction, excellent isopropanol conversion rate, isopropyl ether selectivity and long cycle stability can be reflected.

The application relates to the technical field of boron amine complexes, and discloses a high-purity boron trifluoride monoethylamine complex as well as a preparation method and application thereof. The preparation method of the high-purity boron trifluoride monoethylamine complex comprises the following steps: introducing boron trifluoride into an ethylamine solution to perform a complexation reaction, filtering and washing the filter residue, and drying to obtain the boron trifluoride monoethylamine complex; and the washing agent during the washing process comprises a non-ether alkane solvent and isopropyl ether. Through the technical scheme, the problem of low purity of the boron trifluoride monoethylamine complex in the related art is solved.

The present invention relates to a method for preparing a glucagon-like peptide by precipitating the peptide or precursor peptide by mixing with an anti-solvent comprising diisopropyl ether and acetonitrile. Furthermore, the present invention relates to a peptide conjugated to a solid phase and a pharmaceutical composition comprising liraglutide obtainable according to the method of the present invention.