7 results about "Tert-butyl methyl ether" patented technology

An analysis method for detecting multiple residual solvents during the preparation process of a drug. In the method, a gas chromatographic method is utilized to simultaneously detect 21 organic solvents, i.e. methanol, tetrahydrofuran, ethanol, cyclohexane, diethyl ether, isopropyl acetate, acetone, n-heptane, isopropanol, n-butyl alcohol, acetonitrile, dioxane, dichloromethane, pyridine, tert-butyl alcohol, toluene, tert-butyl methyl ether, N,N-dimethylformamide, n-hexane, dimethyl sulfoxide and ethyl acetate. The method is free from influence of drug types, can be applied to the content detection of multiple residual solvents in drugs, has simple operation and a wide usable range, and saves on the time and cost for drug detection.

The invention belongs to the field of analytical chemistry, and particularly relates to an analysis method for detecting multiple residual solvents in a medicine preparation process. According to the method, 21 organic solvents including methanol, tetrahydrofuran, ethanol, cyclohexane, diethyl ether, isopropyl acetate, acetone, n-heptane, isopropanol, n-butyl alcohol, acetonitrile, dioxane, dichloromethane, pyridine, tert-butyl alcohol, toluene, tert-butyl methyl ether, N, N-dimethylformamide, n-hexane, dimethyl sulfoxide and ethyl acetate are simultaneously detected by adopting a gas chromatographic method. The method is not influenced by drug types, can be applied to content detection of various drug residual solvents, is simple to operate and wide in application, and saves drug detection time and detection cost.

The present application belongs to the fields of pharmaceutical technology and organic synthesis technology, and particularly relates to a method for preparing a brinzolamide intermediate. In the present application, triacetyl-5-chloro-2-(benzylthio)thiophene is dissolved in ethyl acetate, water is added, stirring is performed at 2°C to 10°C while chlorine gas is slowly introduced, and washing with water is then performed to obtain a reaction product. Ammonia gas is slowly introduced into the reaction product, and after the introduction of ammonia gas is completed, the reaction product is sequentially washed with water and saturated brine. After concentrating under reduced pressure until no liquid flows out, tert-butyl methyl ether is added, and after stirring, a solid is collected by means of filtration. The solid is rinsed with tert-butyl methyl ether, and dried to obtain triacetyl-5-chloro-2-thiophene sulfonamide. In the present application, to perform the reaction, water is used for catalysis and chlorine gas is used as both a chlorinating agent and an oxidizing agent, and materials such as sodium tungstate are not used; the preparation method involves simple steps, a shortened reaction time, reduced reaction material consumption and reduced production costs, while achieving the high yield and high purity of a target product.

This application discloses a method for detecting astaxanthin content. The provided method includes the following steps: mixing the sample to be tested with acetone to prepare a test solution; performing high-performance liquid chromatography (HPLC) on the test solution. The HPLC conditions include: using tert-butyl methyl ether as mobile phase A and a mixed solution of methanol and acetonitrile as mobile phase B, with isocratic elution. The provided detection method uses HPLC, employing a mixed solvent of tert-butyl methyl ether and methanol-acetonitrile as the mobile phase, and successfully achieves efficient and rapid separation of astaxanthin through isocratic elution. The chromatographic peak shape is excellent, effectively overcoming interference from proteins, lipids, nutrients, and ionic components in a complex matrix, providing a reliable analytical tool for assessing the intestinal absorption characteristics of astaxanthin.

The application discloses a preparation method and production process of a six-membered aromatic ring fused pyrrole compound, and belongs to the field of organic synthesis. The six-membered aromatic ring fused pyrrole compound of the target compound can be obtained in a high yield even under normal pressure by using specific low-boiling-point solvents (a mixed system of toluene and water). In addition, in the post-treatment process after the reaction is completed, a method of sequentially using sodium chloride aqueous solution washing and t-butyl methyl ether beating is used, so that the by-products can be effectively removed in the post-treatment process, and the product properties are improved.

To provide deoxycytidine compositions with reduced residual solvent content.SOLUTION: Provided is a composition comprising Form B deoxycytidine and at least one residual solvent, the form B deoxycytidine being characterized by a powder X-ray diffraction pattern comprising peaks at 13.7°, 17.2°, 18.0°, 19.2° and 22.8 (2θ) (± 0.2°(2θ)), the at least one residual solvent being selected from the group consisting of methanol, toluene, methylene chloride, ethanol, tert-butylmethyl ether, acetone, ethyl acetate, and n-heptane, and the composition being stable for at least 3 months at 25±2°C and 60±5% relative humidity.SELECTED DRAWING: None

The invention relates to an analysis method for detecting multiple residual solvents in a medicine preparation process, which comprises the following steps of: simultaneously detecting methanol, tetrahydrofuran, ethanol, cyclohexane, diethyl ether, isopropyl acetate, acetone, n-heptane, isopropanol, n-butyl alcohol, acetonitrile, dioxane, dichloromethane, pyridine, tert-butyl alcohol, methylbenzene, tert-butyl methyl ether, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide and N, N-dimethylformamide by adopting a gas chromatographic method; and 21 organic solvents including N, N-dimethylformamide, normal hexane, dimethyl sulfoxide and ethyl acetate are adopted. The method is not influenced by drug types, can be applied to content detection of various drug residual solvents, is simple to operate and wide in application, and saves drug detection time and detection cost.