Extraction and purification method for 6-shogaol

A purification method, the technology of shogaol, which is applied in the field of extraction and purification of active ingredients in natural medicines and Chinese herbal medicines, can solve the problems of high cost, low extraction efficiency, and low purity, and achieve high recovery rate, low price, and good purity Effect

Inactive Publication Date: 2017-10-27
CHONGQING UNIV
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Problems solved by technology

[0012] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a method for extr

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  • Extraction and purification method for 6-shogaol
  • Extraction and purification method for 6-shogaol
  • Extraction and purification method for 6-shogaol

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Embodiment Construction

[0029] The present invention will be described in further detail below in conjunction with specific embodiments and accompanying drawings.

[0030] see figure 1 A method for extracting and purifying 6-shogaol, using ginger and dried ginger as raw materials, pulverizing the raw materials with 70% ethanol, and extracting them in a water bath at 40-55°C. After filtering the medicinal residues, the extract was distilled under reduced pressure to obtain a concentrated solution. The concentrated solution was extracted with petroleum ether to remove impurities, and 6-shogaol was extracted with ethyl acetate. After removing the solvent from the above extract, the ethyl acetate extraction part was subjected to silica gel column chromatography, petroleum ether: ethyl acetate (6:1 ~ 2:1) gradient elution, separated and collected R f= 0.38 (petroleum ether: ethyl acetate = 3: 1) components to obtain the crude product of 6-shogalenol separated by silica gel column chromatography. The cr...

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Abstract

The invention provides an extraction and purification method for 6-shogaol. The method comprises the following steps: taking fresh ginger and rhizoma zingiberis as raw materials; chopping the raw materials or adopting 70% ethyl alcohol for digesting in a 40-55 DEG C water bath after crushing; filtering drug residue and then performing reduced pressure distillation on the extracting liquid, thereby acquiring a concentrated solution; removing impurities by extracting the concentrated solution with petroleum ether and extracting 6-shogaol component by using ethyl acetate; after removing the solvent from the extracting liquid, performing chromatography with silica gel on the ethyl acetate extract part, adopting petroleum ether and ethyl acetate at ratio of (6:1)-(2:1) for performing gradient elution, separating and collecting the component of Rf=0.38 (petroleum ether and ethyl acetate at ratio of (3:1), thus obtaining the separated crude product of 6-shogaol; further thinning and performing chromatographic separation on the crude product of 6-shogaol, thereby acquiring pure product of 6-shogaol and representing the pure product with 1HNMR and 13CNMR. The method is simple in operation, the material cost is low, the time is saved and the purity is high. The acquired 6-shogaol product can be used as a standard product for quality control on the pharmaceutical preparation containing ginger and shogaol, pharmacological research, cosmetics, daily chemical products, and the like.

Description

technical field [0001] The invention belongs to the field of extraction and purification of active ingredients in natural medicines and Chinese herbal medicines. The invention extracts and purifies 6-shogaol from ginger. Background technique [0002] Ginger is the fresh and tender stem of Zingiber officinale. Ginger is used for both medicine and food, which can relieve the exterior and dissipate heat, warm the middle and stop vomiting. It is recorded in "Compendium of Materia Medica" that ginger can treat "malaria cold and heat (spleen and stomach gather phlegm, and send out cold and heat), cold and heat phlegm cough, cholera turning tendons, dying in the abdomen, full pain in the chest and hypochondrium (hard pain in the chest, under the side, hard pain) Fullness), constipation, hot and humid yellow, mouth sores, tooth pain, Chinese medicine poisoning, knife and ax wounds, sprained hands and feet, bruises, armpit body odor, red vitiligo, frostbite in both ears, various po...

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Application Information

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IPC IPC(8): C07C45/78C07C45/79C07C49/255
CPCC07C45/78C07C45/79C07C49/255
Inventor 穆小静吴丁丁李颜肖尚友王成善易小琦
Owner CHONGQING UNIV
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