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Medical application of natural product 6-shogaol in enhancing chemosensitivity of pancreatic cancer on gemcitabine and compound drug composite of natural product 6-shogaol

A technology of gemcitabine and shogaol, applied in the field of natural medicine

Inactive Publication Date: 2013-08-28
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the combination of 6-shogaol and gemcitabine in the treatment of pancreatic cancer has not been reported

Method used

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  • Medical application of natural product 6-shogaol in enhancing chemosensitivity of pancreatic cancer on gemcitabine and compound drug composite of natural product 6-shogaol
  • Medical application of natural product 6-shogaol in enhancing chemosensitivity of pancreatic cancer on gemcitabine and compound drug composite of natural product 6-shogaol
  • Medical application of natural product 6-shogaol in enhancing chemosensitivity of pancreatic cancer on gemcitabine and compound drug composite of natural product 6-shogaol

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] tablet

[0028] The medicine and auxiliary materials are passed through 80 mesh sieves respectively, 7.8 grams of gemcitabine are fully mixed with 48 grams of microcrystalline cellulose and 12 grams of carboxymethyl starch sodium, 10% starch slurry is made into soft materials, granulated with 18 mesh sieves, and dried at 60°C 1. Fully mix 107.5 gram 6-shogaol with 24 gram microcrystalline cellulose, 15 gram starch and 8 gram carboxymethyl starch sodium, 10% starch slurry soft material, 18 mesh sieve granulation, 60 Dry at 100°C to obtain granule 2. According to the principle of equal increase, fully mix granule 1 and granule 2, sieve the granules with 16 meshes, add magnesium stearate, mix well, and compress into tablets, the tablet weight is 500 mg.

Embodiment 2

[0030] soft capsule

[0031] Heat 300 grams of polyethylene glycol 400 to 50°C, slowly stir and add 17.5 grams of povidone to mix evenly, then add 7.45 grams of gemcitabine and 103 grams of 6-shogaol, and stir until the solution is clear and a uniform and stable medicinal solution is formed . The medicinal liquid is introduced into a soft capsule pill press, and soft capsules are prepared according to a conventional soft capsule preparation method.

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Abstract

The invention relates to the field of natural drugs, and discloses medical application of natural product 6-shogaol in enhancing the chemosensitivity of pancreatic cancer on gemcitabine and a compound drug composite of the natural product 6-shogaol. According to the invention, low-dose gemcitabine can generate biological effect under high dose through the combined administration of the 6-shogaol and the gemcitabine, so that the clinical usage amount of the gemcitabine can be greatly reduced, the toxic side effect can be reduced, the clinical treatment safety index can be enhanced, and good clinical application development prospect is achieved.

Description

technical field [0001] The invention relates to the field of natural medicines, and discloses a medical application of a natural product 6-shogaol that can enhance the chemosensitivity of pancreatic cancer to gemcitabine and a compound pharmaceutical composition thereof. Background technique [0002] Pancreatic cancer is a malignant tumor of the digestive tract with hidden clinical manifestations, rapid development, and poor prognosis. Its early diagnosis is difficult and treatment methods are limited, so the mortality rate is high. In western countries, the death rate of pancreatic cancer ranks fourth; in my country, pancreatic cancer is also one of the three major digestive tract malignancies. Traditional treatments for pancreatic cancer mainly include surgery, radiotherapy, and chemotherapy. So far, surgery is still the most effective treatment for pancreatic cancer, but pancreatic cancer lacks obvious symptoms in the early stage, and most cases have lost the chance of r...

Claims

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Application Information

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IPC IPC(8): A61K31/7068A61K31/12A61P35/00
Inventor 李萍徐晓军周玲齐练文马江
Owner CHINA PHARM UNIV
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