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Separating and purifying method for shogaol

A technology of separation and purification, sorghum, applied in the field of separation and purification of natural active ingredients, can solve the problems of unsatisfactory medical use, complex components, etc., and achieves the effects of simple implementation, high crystal purity, and easy industrial production.

Inactive Publication Date: 2005-10-19
GUANGZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content of gingerol in the ginger essential oil is relatively high (50-70%), so it tends to be separated out in the steam distillation process, but in the above cases, the gingerol always coexists with the ginger essential oil, and its composition is complex, which cannot meet the requirements of medical use. Require

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) after steam distillation of gingerol, separate the mixture of water, gingerol oil and gingerol in the obtained distillate, and filter to obtain the coarse crystal of gingerol;

[0021] (2) Add 1 part by weight of ethanol or acetone to 1 part of the crude crystal obtained in (1), then add 20 parts by weight of distilled water;

[0022] (3) adjust the pH of the solution to be 6, place it for 25 hours, and crystallize out;

[0023] (4) Filtration, vacuum drying, and thin-layer chromatography to monitor the separation effect.

[0024] The infrared spectrogram of the isolated gingerol crystal shows that its purity is not lower than 97%; the nuclear magnetic resonance spectrogram shows that its purity is 97%.

Embodiment 2

[0026] (1) after steam distillation of gingerol, separate the mixture of water, gingerol oil and gingerol in the obtained distillate, and filter to obtain the coarse crystal of gingerol;

[0027] (2) Add 1 part by weight of ethanol or acetone to 1 part of the crude crystal obtained in (1), then add 30 parts by weight of distilled water;

[0028] (3) adjust the pH of the solution to be 7, place it for 30 hours, and crystallize out;

[0029] (4) Filtration, vacuum drying, and thin-layer chromatography to obtain needle-shaped gingerol crystals.

[0030] Detected by infrared spectrum and nuclear magnetic resonance spectrum, the result is that the purity is 93%.

Embodiment 3

[0032] (1) steam distillation, separating the mixture of water and gingerol oil and gingerol obtained by separation, and filtering to obtain the coarse crystal of gingerol;

[0033] (2) Add 2 parts by weight of ethanol or acetone to 1 part of the crude crystal obtained in (1), then add 15 parts by weight of distilled water;

[0034] (3) adjust the pH of the solution to be 4, place it for 20 hours, and crystallize out;

[0035] (4) Filtration, vacuum drying, and thin-layer chromatography to obtain needle-shaped gingerol crystals.

[0036] Detected by infrared spectrum and nuclear magnetic resonance spectrum, the result is that the purity is 90%.

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PUM

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Abstract

The shogaol separating and purifying process includes the following steps: 1. separating water, Kaempferia galanga oil and shogaol in the distilled mixture, and filtering to obtain coarse shogaol crystal; 2. adding alcohol or acetone in 1-3 times the weight of coarse shogaol crystal into the coarse shogaol crystal and adding distilled water in 15-35 times the weight; 3. regulating pH value of the solution to 4-8, setting for 20-40 hr to separate crystal; and 4. filtering and vacuum drying to obtain high purity shogaol crystal. The product is used in medicine.

Description

technical field [0001] The invention relates to the separation and purification technology of natural active ingredients, which is a method for purifying the single active ingredient gingerol (ethyl p-methoxy cinnamate) in the natural plant zingibera. Background technique [0002] Sand ginger (Kaempferia galanga L.) belongs to Xianghe family and is the rhizome of Zingiberaceae kaempferia plant. The main active ingredients in the dry ginger are: 3-4% of gingerol and essential oil of ginger, and 30%-50% of starch. Gingerol mainly contains ethyl p-methoxycinnamate. (p-methoxy-ethyl-Cinnamate, also known as gingerol crystals). It has been reported at home and abroad that it has significant anti-cancer activity, antibacterial activity, anti-oxidation, etc. Gingerol should be pure as a medicine. [0003] Due to the complex components in ginger brain, it is not a single compound. The content of gingerol in the ginger essential oil is relatively high (50...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C67/54C07C69/734
Inventor 樊亚鸣陈永亨
Owner GUANGZHOU UNIVERSITY
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