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Double stimuli responsive type poly amino acid-based supermolecular reverse gel and method for preparing same

A dual-stimuli-response, polyamino acid technology, applied in the field of chemical gel and its preparation, can solve the problems of undiscovered prior art and achieve the effect of simple preparation method and fast gelation speed

Inactive Publication Date: 2010-03-31
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] After searching the prior art, no similar prior art in this field was found

Method used

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  • Double stimuli responsive type poly amino acid-based supermolecular reverse gel and method for preparing same

Examples

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Effect test

Embodiment 1

[0023] Example 1: Preparation of linear polyamino acid-based supramolecular reverse gel

[0024] Polyethylene glycol (MPEO-NH 2 ) as a macroinitiator to initiate the ring-opening polymerization of γ-benzyl-L-glutamic acid-N-carboxy anhydride (BLG-NCA), and then use acetic acid (CH 3 COOH) and hydrobromic acid (HBr) mixed system, after taking off the benzyl group of the PBLG segment, the poly(L-glutamic acid)-polyethylene glycol (PLG) used to form the reverse gel is obtained 35 -b-PEO) diblock copolymer with an arm length of 35 repeating units.

[0025] Using the above diblock copolymer (PLG 35 -b-PEO, 40mg) was added to a 5mL volumetric flask containing magnetic particles, and 1mL deionized water was added. After stirring, the polymer was insoluble, and the solution was cloudy with a small amount of precipitation; 12μL 3mol / L NaOH solution was taken with a micro syringe, and made Its pH ~ 8, at this time the system is clear and transparent, then add 60mg α-CD under vigorous...

Embodiment 2

[0028] Example 2: Preparation of polyamino acid-based supramolecular reverse gel with eight arms

[0029] Using methoxypolyethylene glycol (MPEO-D) with 8 branched amino groups at one end 3 ) as a macroinitiator to initiate the ring-opening polymerization of γ-benzyl-L-glutamic acid-N-carboxy anhydride (BLG-NCA), and then use acetic acid (CH 3 COOH) and hydrobromic acid (HBr) system, after removing the benzyl protection of the PBLG segment, the eight-armed poly(L-glutamic acid)-polyethylene glycol (D3-PBLG) used to form the reverse gel was obtained 13 -b-PEO) a diblock copolymer with an arm length of 13 repeating units.

[0030] Using the above diblock copolymer (D3-PLG 13 -b-PEO, 40mg) was added to a 5mL volumetric flask containing magnetic particles, and 1mL deionized water was added. After stirring, the polymer was insoluble, and the solution was cloudy with a small amount of precipitation; 70μL 3mol / L NaOH solution was taken with a micro-syringe to make Its pH=8, at thi...

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Abstract

The invention provides a double stimuli responsive type poly amino acid based supermolecular reverse gel used in the technical field of water gel and a method for preparing the same, wherein the method comprises the following steps of: synthesizing a linear poly(L-benzyl-glutaric acid ester)-polyethylene glycol diblock copolymer; preparing a poly(L-glutamic acid)-polyethylene glycol di-block copolymer used for forming the reverse gel; forming the supermolecular reverse micelle in which the alpha-cyclodextrin-polyethylene glycol complex serves an inner core and the poly(L-glutamic acid) servesa shell; and protonating the poly(L-glutamic acid) chain segments in an acid environment, forming crosslinking by using the mutual action of the hydrogen bonds between the poly(L-glutamic acid) chainsegments, and allowing the supermolecular reverse micelles to mutually gather to form the double stimuli responsive type poly amino acid-based supermolecular reverse gel at room temperature. Comparedwith the prior art, the elastic modulus of the gel is further improved, the gel system prepared by the method is damaged when the pH value of the gel system is higher than 8, the reverse gel can be formed again when the pH value of the gel system is adjusted to be 5, so that the pH value reversibility is good.

Description

technical field [0001] The invention relates to a chemical gel in the technical field of chemical engineering and a preparation method thereof, in particular to a dual stimulus-responsive polyamino acid-based supramolecular reverse gel and a preparation method thereof. Background technique [0002] Unlike chemical gels, the network structure in supramolecular gels is formed by weak interactions such as intermolecular hydrogen bonds, π-π stacking, hydrophobic interactions, and electrostatic interactions. Moreover, supramolecular hydrogels often produce large volume phase transitions with changes in external environments such as temperature, pH value, solvents, electromagnetic fields, or chemical substances. At present, supramolecular hydrogels have received extensive attention in the fields of controlled drug release, tissue engineering, smart materials, biosensors, and enzyme immobilization. Based on the fact that temperature and pH are two important factors in physiologica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/48C08G69/10C08G65/48C08J3/075C08L5/16C08L71/00C08L77/04
Inventor 陈怡董常明
Owner SHANGHAI JIAO TONG UNIV
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