Silver nanoparticles with function of identifying chiral isomer, preparation method thereof and application thereof

A technology of nano-silver particles and chiral isomers, applied in chemical instruments and methods, measurement of color/spectral characteristics, and analysis through chemical reactions of materials, etc., can solve the problems of narrowing the application range and achieve a wide range of use , good operability and simple process

Inactive Publication Date: 2011-01-05
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, sensors or electrodes can only rely on a single moiety or exchange to achieve the necessary chiral selectivity, which greatly narrows their application range.

Method used

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  • Silver nanoparticles with function of identifying chiral isomer, preparation method thereof and application thereof
  • Silver nanoparticles with function of identifying chiral isomer, preparation method thereof and application thereof
  • Silver nanoparticles with function of identifying chiral isomer, preparation method thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, preparation 6-mercapto-alpha-cyclodextrin modified silver nanoparticles

[0030] 1) Weigh 21g of triphenylphosphine and 20.2g of iodine and dissolve in 80ml of N,N-dimethylformamide, add 4.32g of α-cyclodextrin after fully dissolved, and react at 80°C for 15 hours. Concentrate in vacuo to 40ml, add 30ml of sodium methoxide-methanol solution with a concentration of 3mol / L, and adjust the pH value to 9.5. The system was cooled to 25°C, and after stirring for 30 minutes, the system was precipitated with 800 ml of methanol, the precipitate was washed with methanol, and dried in vacuum to obtain 6-iodo-α-cyclodextrin.

[0031] 2) Dissolve 0.965 g of 6-iodo-α-cyclodextrin in 10 ml of N,N-dimethylformamide, and add 0.301 g of thiourea. Stir and heat up to 70°C, and react for 19 hours under nitrogen protection. After the reaction was completed, N,N-dimethylformamide was distilled off under reduced pressure to obtain 0.914 g of compound a as a yellow oil.

[003...

Embodiment 2

[0036] Embodiment 2, preparation 6-mercapto-α-cyclodextrin modified silver nanoparticles

[0037] 1) Weigh 23g of triphenylphosphine and 21.2g of iodine and dissolve in 85ml of N,N-dimethylformamide, add 4.52g of α-cyclodextrin after fully dissolved, and react at 83°C for 19 hours. Concentrate in vacuo to 42ml, add 31ml of sodium methoxide-methanol solution with a concentration of 3.2mol / L, and adjust the pH value to 10. The system was cooled to 25°C, and after stirring for 35 minutes, the system was precipitated with 1000 ml of methanol, the precipitate was washed with methanol, and dried in vacuum to obtain 6-iodo-α-cyclodextrin.

[0038] 2) 1 g of 6-iodo-α-cyclodextrin was dissolved in 15 ml of N,N-dimethylformamide, and 0.4 g of thiourea was added. Stir and heat up to 70°C, and react for 20 hours under nitrogen protection. After the reaction was completed, N,N-dimethylformamide was distilled off under reduced pressure to obtain 0.963 g of compound a as a yellow oil.

[...

Embodiment 3

[0041] Example 3, preparation of silver nanoparticles modified by 6-mercapto-α-cyclodextrin

[0042] 1) Weigh 20g of triphenylphosphine and 19.2g of iodine and dissolve in 75ml of N,N-dimethylformamide. After fully dissolving, add 4.12g of α-cyclodextrin and react at 83°C for 13 hours. Concentrate in vacuo to 38ml, add 28ml of sodium methoxide-methanol solution with a concentration of 2.9mol / L, and adjust the pH value to 9. The system was cooled to 25° C., stirred for 29 minutes, and precipitated with 750 ml of methanol. The precipitate was washed with methanol and dried in vacuum to obtain 6-iodo-α-cyclodextrin.

[0043] 2) Dissolve 0.9 g of 6-iodo-α-cyclodextrin in 5 ml of N,N-dimethylformamide, and add 0.2 g of thiourea. Stir and heat up to 65°C, and react for 18 hours under nitrogen protection. After the reaction was completed, N,N-dimethylformamide was distilled off under reduced pressure to obtain 0.875 g of compound a as a yellow oil.

[0044] 3) Add 45 ml of deioni...

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Abstract

The invention discloses silver nanoparticles with a function of sensitively identifying chiral isomer, a preparation method thereof and application thereof. The silver nanoparticles modified by 6-sulfydryl-alpha-cyclodextrin consist of the silver nanoparticles and the 6-sulfydryl-alpha-cyclodextrin which are connected by chemical bonds. In the invention, the silver nanoparticles modified by water soluble alpha-cyclodextrin are prepared by preparing stable silver nanoparticles by using silver nitrate as a source and then modifying the stable silver nanoparticles with the alpha-cyclodextrin serving as a chiral selector and by a simple method, so that the colorimetric differentiation and identification of many D-type amino acids and many L-type amino acids are realized successfully. The chiral isomer detection method provided by the invention has a simple process and high operability and can be efficiently applied to the detection of chiral amino acids and chiral medicaments.

Description

technical field [0001] The invention belongs to the field of nano optics and biotechnology, and relates to a stable nano-silver particle and its preparation method and application, in particular to a nano-silver particle with the function of sensitively identifying chiral isomer molecules, and its preparation method and application. Background technique [0002] Most biomolecules are chiral, and chiral compounds are closely related to life processes. For example, L-amino acids dominate in life forms, however, D-amino acids play an important role in physiology and pathology. Because of the significant differences in biological activity and metabolic process of different chiral isomers in the living body, simple, fast and accurate chiral molecular recognition methods have attracted people's interest in recent years. At present, chiral recognition is mainly realized by separation methods such as HPLC, CE, and TLC combined with photometric detection. Although separation methods...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/58C08B37/16G01N21/31G01N21/78
Inventor 邹纲陈鑫蒋皓王亚丽潘秀娟饶金安冷靖
Owner UNIV OF SCI & TECH OF CHINA
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