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Bacteriostatic hydrocolloid dressing and preparation method thereof

A hydrocolloid and hydrophilic colloid technology, applied in the fields of biological materials and medical supplies, can solve the problems of not being able to give full play to the biological activity of chitosan, not improving the quality of wound healing, and single function, and achieving excellent ability to absorb exudate , Good healing environment, strong paste effect

Inactive Publication Date: 2010-10-20
WUHAN RUIER BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Some manufacturers at home and abroad use chitosan or its derivatives as raw materials to prepare hydrocolloids to produce dressings. Although the obtained hydrocolloids can partially maintain the activity of chitosan, it is difficult to form a wet dressing on the wound. Or, although it can form a moist environment, it cannot fully exert the biological activity of chitosan, so that it has poor antibacterial property and single function, and cannot improve the quality of wound healing.

Method used

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  • Bacteriostatic hydrocolloid dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 1.5 kg of medical-grade ethylene propylene rubber, 1.0 kg of gelatin, 1 kg of mineral oil and 0.2 kg of phytic acid, mix them thoroughly with an internal mixer, then add 3.0 kg of sodium carboxymethyl cellulose, 1.0 kg of calcium alginate, 1.0 kg of viscose resin, 1.2 kg of O-carboxymethyl chitosan, and 0.1 kg of dry nano silver powder are mixed uniformly to form a blend. Among them, mineral oil and tackifying resin are both medical grade; O-carboxymethyl chitosan has a molecular weight of 100,000 to 500,000, a degree of deacetylation of 70%, a degree of carboxymethylation of 0.5 to 0.7, and a degree of substitution of the 6-hydroxyl 0.9; The particle size of the dry nano-silver powder is 100-1000nm; the molecular weight of sodium carboxymethyl cellulose is 20,000-50,000, and the degree of deacetylation is 70%. The above blend is uniformly coated on one side of a microporous polyurethane membrane with a pore size of 0.2μm-10μm and a thickness of 0.01mm-0.02mm to for...

Embodiment 2

[0027] Take 2.0 kg of medical grade ethylene propylene rubber, 1.0 kg of gelatin, 1 kg of mineral oil and 0.2 kg of phytic acid, mix them thoroughly with an internal mixer, then add 2.5 kg of sodium carboxymethyl cellulose, 1.0 kg of calcium alginate, 1.0 kg of viscose resin, 1.2 kg of O-carboxymethyl chitosan, and 0.1 kg of dry nano silver powder are mixed uniformly to form a blend. Among them, mineral oil and tackifying resin are both medical grade; O-carboxymethyl chitosan has a molecular weight of 500,000-1,000,000, a degree of deacetylation of 75%, a degree of carboxymethylation of 0.7-0.9, and a degree of substitution of the 6-hydroxyl It is 0.7; the molecular weight of sodium carboxymethyl cellulose is 80,000-150,000, and the degree of deacetylation is 75%; the particle size of the nano-silver dry powder is 1000-3000nm. The above blend is uniformly coated on one side of a microporous polyurethane membrane with a pore size of 0.2μm-10μm and a thickness of 0.01mm-0.02mm to...

Embodiment 3

[0030] Take 1.5kg of medical grade ethylene propylene rubber, 0.8kg of gelatin, 1kg of mineral oil and 0.2kg of phytic acid, mix them thoroughly with an internal mixer, then add 3.0kg of sodium carboxymethylcellulose, 1.2kg of calcium alginate, 1.0 kg of viscose resin, 1.2 kg of O-carboxymethyl chitosan, and 0.1 kg of dry nano silver powder are mixed uniformly to form a blend. Among them, mineral oil and tackifying resin are both medical grade; O-carboxymethyl chitosan has a molecular weight of 1,000,000-1,500,000, a degree of deacetylation of 80%, a degree of carboxymethylation of 0.9-1.2, and a degree of substitution of the 6-position hydroxyl group. It is 0.8; the molecular weight of sodium carboxymethyl cellulose is 200,000-300,000, and the degree of deacetylation is 85%; the particle size of nano-silver dry powder is 3000-6000 nm. The above blend is uniformly coated on one side of a microporous polyurethane membrane with a pore size of 0.2μm-10μm and a thickness of 0.01mm-...

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Abstract

The invention discloses a bacteriostatic hydrocolloid dressing and a preparation method thereof. The dressing comprises a polyurethane film, a hydrophilic colloid layer and a peeling layer which are adhered in turn. The preparation method comprises the following steps of: mixing a medical grade rubber substrate, gelatin, mineral oil, an antioxidant, sodium carboxymethyl cellulose, calcium alginate, a tackifier, O-carboxymethyl chitosan and dried nano-silver powder uniformly to obtain a blend; uniformly coating the obtained blend on the polyurethane film to form the hydrophilic colloid layer; covering the peeling layer on the hydrophilic colloid layer; and stamping to obtain the bacteriostatic hydrocolloid dressing. The bacteriostatic hydrocolloid dressing of the invention has high bacteriostasis, and simultaneously has the characteristics of high capacity of absorbing transudate, waterproofness, air permeability, firm adhesion, high compliance, capability of meeting diversified requirements on complicated wound, and simple and easily-implemented preparation method.

Description

Technical field [0001] The invention relates to a bacteriostatic hydrocolloid dressing and a preparation method thereof, and belongs to the field of medical supplies and also to the field of biological materials. Background technique [0002] Hydrocolloid dressing is a new type of medical dressing, mainly used in clinically difficult wounds. Hydrocolloid dressings are popular among medical staff because of their ability to create a moist healing environment and their semipermeable membrane properties. Compared with traditional dressings, hydrocolloid dressings have the following advantages: faster healing, no adhesion to the wound when changing dressings, easy operation by nurses, impermeable bacteria, alleviating wound pain, and reducing the number of dressing changes. [0003] Some existing hydrocolloid dressings generally use cellulose derivative sodium carboxymethyl cellulose as the main raw material, such as the Kanghuier ulcer patch from Coloplast, Urgotul from France, and M...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/30A61L15/28A61L15/26A61L15/44
Inventor 陈思全邹伟
Owner WUHAN RUIER BIOTECH
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