Application of Danshensu in preparation of medicine for treating cerebrovascular diseases

A technology of cerebrovascular disease and danshensu, applied in the field of application of danshensu in the preparation of drugs for treating cerebrovascular diseases

Inactive Publication Date: 2005-11-30
YANTAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report about Danshensu having the effect of treating cerebrovascular disease in the body; In view of this, the inventor has found that Danshensu has the medical application of treating cerebrovascular disease through a large number of experimental studies

Method used

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  • Application of Danshensu in preparation of medicine for treating cerebrovascular diseases

Examples

Experimental program
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Effect test

preparation example 1

[0016] Preparation Example 1: Preparation of Danshensu Freeze-dried Powder for Injection

[0017] Precisely weigh 20.0g of Danshensu raw material and 40.0g of medicinal mannitol, dissolve in 1000ml of water for injection, stir well to dissolve, add water for injection to 2000ml, add 2.0g of activated carbon for needles, heat to 60°C and stir for 30 minutes , carbon rod filtration, and the filtrate was sterilized by filtration through a 0.25 μm microporous membrane, divided into 1000 vials, with a filling volume of 2.0ml / vial, and freeze-dried to obtain the product. Each bottle contains danshensu 20mg.

preparation example 2

[0018] Preparation Example 2: Preparation of Danshensu Injection

[0019] Accurately weigh 20.0g of Danshensu raw material, dissolve in 1000ml of water for injection, stir well to dissolve, add water for injection to 2000ml, add 2.0g of activated carbon for needles, heat to 60°C and stir for 30 minutes, filter with carbon rod, and filtrate through Sterilize by filtration with a 0.25 μm microporous membrane, pack in 1,000 vials with a filling volume of 2.0 ml / bottle, seal, and sterilize. Each bottle contains danshensu 20mg.

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Abstract

The present invention provides application of Danshensu in preparation of medicine for treating cerebrovascular diseases, concretely relates to application of Danshensu in preparation of medicine for treating ischemic stroke, application of Danshensu in preparation of medicine for treating NMDA receptor derivation neurons in the brain damage, application of Danshensu in preparation of medicine for treating brain trauma. The invention also provides medicine composition containing Danshensu for treating cerebrovascular diseases, whose unit dose is 50-200mg.

Description

technical field [0001] The invention relates to the application of danshensu in the preparation of medicines for treating cerebrovascular diseases. Background technique [0002] With the acceleration of population aging and the change of lifestyle, cerebrovascular disease has become a global health problem, and the death rate of cerebrovascular accident ranks second in the world, which greatly endangers people's health. The development of new and effective drugs for the prevention and treatment of cerebrovascular diseases is an urgent clinical need. [0003] Danshensu is a water-soluble component of traditional Chinese medicine Danshen, which has the effects of dilating blood vessels, increasing coronary blood flow, and antithrombotic effects. It is an active ingredient in Compound Danshen Dripping Pills and Danshen Injection. [0004] [0005] Danshensu structural formula [0006] The traditional Chinese medicine Danshen is widely used in the treatm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192
Inventor 田京伟王超云孙芳张太平蒋王林傅风华
Owner YANTAI UNIV
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