Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Beta-tricalcium phosphate bearing tetracycline and preparation method thereof

A technology of tricalcium phosphate and tricalcium phosphate powder, applied in medical science, prosthesis, etc.

Inactive Publication Date: 2010-01-06
HUAZHONG UNIV OF SCI & TECH
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no technology of β-tricalcium phosphate powder bearing tetracycline and its preparation method disclosed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018] Dissolve tetracycline hydrochloride powder in deionized water to form a tetracycline solution with a concentration of 4g / L; take the precursor of β-tricalcium phosphate powder prepared by the precipitation method, and after calcination at 800°C for 2 hours, the specific surface area is 14 m 2 β-tricalcium phosphate powder per gram; take tetracycline solution and β-tricalcium phosphate powder respectively by weighing the tetracycline solution and β-tricalcium phosphate powder according to the mass ratio of tetracycline and β-tricalcium phosphate; soak the β-tricalcium phosphate powder in In the tetracycline solution, stir to form a suspension of β-tricalcium phosphate in the tetracycline solution; continue to stir the suspension of β-tricalcium phosphate in the tetracycline solution for 30 minutes, then stop stirring; atomize the suspension into droplets through a sprayer , the droplets are cooled with liquid nitrogen into ice particles, and the ice particles are kept at ...

example 2

[0020] Dissolve tetracycline hydrochloride powder in deionized water to form a tetracycline solution with a concentration of 4g / L; commercially available β-tricalcium phosphate powder is calcined at 1000°C for 2 hours to obtain a specific surface area of ​​7 m 2 β-tricalcium phosphate powder per gram; take tetracycline solution and β-tricalcium phosphate powder respectively by weighing the tetracycline solution and β-tricalcium phosphate powder according to the mass ratio of tetracycline and β-tricalcium phosphate; soak the β-tricalcium phosphate powder in In the tetracycline solution, stir to form a suspension of β-tricalcium phosphate in the tetracycline solution; after stirring the suspension for 30 minutes, separate it from the solid and liquid by suction; the solid phase part is dried in a 30°C drying oven Treat for 24 hours to remove water to obtain tetracycline-loaded β-tricalcium phosphate powder with a tetracycline load of less than 0.004 g / g.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a Beta-tricalcium phosphate bearing tetracycline. The tetracycline is absorbed on the surface of the Beta-tricalcium phosphate, and the mass ratio of the tetracycline and the Beta-tricalcium phosphate is (0.001-0.1):1. The invention also provides a preparation method of the Beta-tricalcium phosphate bearing tetracycline, comprising the following steps: dissolving teline powder in a tetracycline solution formed in deionized water, uniformly mixing the calcined Beta-tricalcium phosphate powder and the tetracycline solution, extracting a solid component in the mixed solution, finally drying the solid component, and preparing and obtaining Beta-tricalcium phosphate powder bearing tetracycline on the surface. The Beta-tricalcium phosphate prepared by the method has better tetracycline bearing capacity, is used for repairing and replacing osseous tissues and also effectively eliminates postoperative inflammation.

Description

technical field [0001] The invention relates to the field of biological implant materials, in particular to a β-tricalcium phosphate bearing tetracycline and a preparation method thereof. Background technique [0002] β-tricalcium phosphate has excellent osteoconductivity, biodegradability, and biocompatibility, and is an ideal bioimplantation material, often used for bone tissue repair and replacement. The implantation process of β-tricalcium phosphate implant material is often accompanied by surgery, which can bring about inflammation. In order to eliminate postoperative inflammation, patients can be given injections or oral anti-inflammatory drugs, but the best way is to release anti-inflammatory drugs at a certain speed locally in the surgical area by the β-tricalcium phosphate implant material loaded with its own drug. [0003] The existing β-tricalcium phosphate implant material preparation process is as follows: β-tricalcium phosphate powder is molded into a parison ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/12A61L27/54
Inventor 肖建中夏风李艳毛靖张智星付涛
Owner HUAZHONG UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com