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Sustained-release bromfenac sodium ophthalmic preparation

A technology of bromfenac sodium and ophthalmic preparations, applied in the field of sustained-release bromfenac sodium ophthalmic preparations, can solve the problems of large side effects, easy occurrence of corneal hyperemia, etc., and achieves small side effects, good intraocular penetration, Achieve the effect of industrial mass production

Active Publication Date: 2019-12-06
合肥华威药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there are many kinds of bromfenac sodium ophthalmic preparations on the market in China. The original research is bromfenac sodium eye drops (trade name: Pronaac) produced by Senshou Pharmaceutical Co., Ltd., but its side effects are relatively large. Dosage and method of use sho

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  • Sustained-release bromfenac sodium ophthalmic preparation
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Abstract

The invention relates to an ophthalmic pharmaceutical preparation for treating conjunctivitis, scleritis and eye postoperative inflammations, in particular to a sustained-release bromfenac sodium ophthalmic preparation. The sustained-release bromfenac sodium ophthalmic preparation provided by the invention is prepared from bromfenac sodium, carthamin yellow, sodium hyaluronate and a pharmacologically acceptable carrier. The sustained-release bromfenac sodium ophthalmic preparation provided by the invention has the advantages of good intraocular penetrability, high intraocular bioavailability,high penetration, high targeting effect, small toxic and side effects and the like, and is suitable for treating inflammatory eye diseases and used for treating conjunctivitis, scleritis and eye postoperative infection.

Description

technical field [0001] The invention relates to an ophthalmic pharmaceutical preparation for treating conjunctivitis, scleritis and eye postoperative inflammation, in particular to a sustained-release bromfenac sodium ophthalmic preparation. Background technique [0002] Inflammation is the manifestation of host tissue response to damaged blood vessels and cells. Tissue damage may be caused by physical or chemical causes, such as pathogen invasion, ischemia, allergies or improper (autoimmune) functioning of immune mechanisms. At this time, arachidonic acid is released from the phospholipids of the cell membrane, and under the catalysis of cyclooxygenase, it forms ring peroxides (PGG2 and PGH2), and then converts them into prostaglandins (PGE2, PGF2, PGD2) through the action of isomerase. ), and prostaglandins are the most powerful ocular inflammatory substances known to date, which can cause damage to the blood-aqueous humor barrier in the eyes, thereby making proteins, var...

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Application Information

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IPC IPC(8): A61K9/06A61K47/36A61K47/26A61K31/196A61P27/02A61P29/00A61P31/00
CPCA61K9/0048A61K9/06A61K31/196A61K47/26A61K47/36A61P27/02A61P29/00A61P31/00
Inventor 黄凌云王延东
Owner 合肥华威药业有限公司
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