Medical nanofiber reinforced hydrophilic composite material as well as preparation method and application thereof

Abstract

The invention discloses a medical nanofiber reinforced hydrophilic composite material as well as a preparation method and application thereof. The composite material is prepared from a hydrophilic basis material and nano staple fibers, wherein the nano staple fibers are maintained in crystal morphology and are uniformly dispersed in the hydrophilic basis material; the mass percent of the nano staple fibers in the composite material is 1 to 30 percent; the nano staple fibers have the diameters of 200nm to 800nm and the lengths of 10mu m to 100mu m; according to the preparation method of the medical nanofiber reinforced composite material, which is provided by the invention, the technological design is peculiar; the nano staple fibers are uniformly dispersed in the basis material by utilizing the solubility difference of the basis material and the nano staple fibers; the multicellular spongy composite material is obtained by adopting a freeze drying method; the composite material keeps the respective advantages of two materials; defects are complementary; the composite material which is excellent in mechanical performance, good in biocompatibility and good in biodegradability is obtained, and the medical nanofiber reinforced hydrophilic composite material is moderate in degradation cycle, cannot cause a postoperative inflammation and the postoperative risk of adhesion, is more suitable for clinical demand.

Description

technical field [0001] The invention relates to the technical field of nanofiber composite materials, in particular to a medical nanofiber-reinforced hydrophilic composite material and its preparation method and application. Background technique [0002] Various tissues and organs in the human body may be abnormal or damaged. At present, the transplantation of tissues and organs is mainly used to restore their functions. In this process, a large amount of biological materials are needed to support the normal work of tissues and organs, such as stents, Ligation clips, etc., materials with good biocompatibility and biodegradability can finally form new functional tissues with the further proliferation and differentiation of cells and the degradation and absorption of materials to achieve the purpose of repairing defective tissues. The demand in the market is also increasing. [0003] Medical materials prepared from single-component polymer raw materials have high elongation a...

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Problems solved by technology

[0003] Medical materials prepared from single-component polymer raw materials have high elongation at break, good flexibility, and little damage to blood vessels and other tissues, but they also have the following shortcomings, such as slow degradation speed, poor tensile strength, and falling off. It takes 1 to 2 months, and it takes more than 6 months for complete absorption. In clinical practice, the closure time of blood vessels and other tubular tissues is only 1 to 2 weeks. There are potential risks in the long-term use of medical materials in the human body. In addition, blood vessels or other tissues may still Phenomena such as damage and bleeding are not conducive to the recovery of patients; while simple grafting or copolymerization of two materials is used, the composition ratio, segment distribution, molecular weight, etc. are not easy to control stably, and the mechanical properties and biodegradability of the material are very low. It is difficult to meet the requirements at the same time, so it cannot fully meet the clinical needs of medical polymer materials

[0004] Natural bioabsorbable polymer materials, such as collagen, gelatin, hyaluronic acid, chitosan, etc., have good hydrophilicity, biocompatibility, and biodegradability. Compared with synthetic materials, they have cell signal recognition. It can promote cell adhesion, proliferation and differentiation, and can be used for tissue regeneration and repair materials. However, this type of material also has the following disadvantages. The mechanical properties are low, especially after contact with water, the strength will further decrease or deform. In clinical application When the product is broken, it may fall off and other undesirable phenomena, which limits the application of this type of material

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