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Intraocular lens with concentric ring pattern and surface modified by degradable drug sustained-release coating and preparation method of intraocular lens with concentric ring pattern and surface modified by degradable drug sustained-release coating

A technology of intraocular lens and surface modification, which is applied in the direction of drug devices, intraocular lenses, prostheses, etc., can solve the problem of difficult control of drug loading and release kinetics of the coating, the inability to guarantee the effectiveness and safety of drugs, and the inability to Large-scale industrial mass production and other issues, to achieve the effect of easy acquisition and promotion, small stability and foldability, strong repeatability and stability

Pending Publication Date: 2021-09-21
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned drug-loaded intraocular lens can inhibit the proliferation of lens epithelial cells relatively well, it also has some disadvantages: 1) The preparation process is complicated and inefficient, and it cannot be mass-produced on a large scale; 2) The quality of the coating is not easy to control and difficult to customize Coating properties, etc.; 3) It is difficult to control the drug loading and release kinetics of the coating, and the effectiveness and safety of the drug cannot be guaranteed, etc.

Method used

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  • Intraocular lens with concentric ring pattern and surface modified by degradable drug sustained-release coating and preparation method of intraocular lens with concentric ring pattern and surface modified by degradable drug sustained-release coating
  • Intraocular lens with concentric ring pattern and surface modified by degradable drug sustained-release coating and preparation method of intraocular lens with concentric ring pattern and surface modified by degradable drug sustained-release coating
  • Intraocular lens with concentric ring pattern and surface modified by degradable drug sustained-release coating and preparation method of intraocular lens with concentric ring pattern and surface modified by degradable drug sustained-release coating

Examples

Experimental program
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Effect test

preparation example Construction

[0033] The preparation method of the degradable drug sustained-release coating surface-modified intraocular lens having concentric ring patterns as described above comprises the following steps:

[0034] 1) Prepare the intraocular lens according to the design plan, wash it and set it aside;

[0035] 2) Preparation of sustained-release pharmaceutical composition: uniformly mix degradable polymer, drug and organic solvent to obtain sustained-release pharmaceutical composition;

[0036] 3) Preparation of drug sustained-release intraocular lens: Spin-coat the sustained-release pharmaceutical composition prepared in step 2) onto the surface of the intraocular lens prepared in step 1) by using a homogenizer to volatilize the organic solvent in the drug coating;

[0037] 4) The drug slow-release intraocular lens prepared in step 3) is sterilized and then sealed and packaged.

[0038] In the spin coating solution obtained in step 2), the concentration of the degradable polymer is 5-5...

Embodiment 1

[0058] Example 1: In order to visually show the concentric ring pattern of the prepared drug-loaded coating, this example uses red eosin as a model drug to carry out the preparation of the drug-loaded coating. Take 7.5ml polylactic acid-glycolic acid copolymer (PLGA) and 2.5mg / ml eosin in acetone and magnetically stir overnight to mix evenly, place the hydrophobic acrylate intraocular lens simulation material in the center on the homogenizer, set the spin coating parameters, Low-speed rotation 600rpm, 10s; high-speed rotation speed 2000rpm, 30s; static dispensing 10μl, start the glue homogenizer, get eosin drug slow-release coating with concentric ring pattern (such as figure 1 shown).

Embodiment 2

[0060] Take 50mg / ml polyε-caprolactone (PCL) and 25mg / ml rapamycin in chloroform and magnetically stir overnight to mix evenly, place the silicone gel intraocular lens in the center on the plate holder of the homogenizer, set the rotary Coating parameters: low-speed rotation speed 1000rpm, 30s; high-speed rotation speed 6000rpm, 30s; dynamic glue dispensing 100μl, start the glue homogenizer, and obtain the intraocular lens modified by the rapamycin sustained-release coating with concentric ring pattern.

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Abstract

The invention relates to the field of medical implant materials and instrument surface modification in the ophthalmology department, in particular to a foldable intraocular lens with a concentric ring pattern, drug sustained release function and a surface modified by a degradable drug sustained-release coating, and a preparation method of the foldable intraocular lens. The degradable drug sustained-release coating with the concentric ring pattern is formed by spin-coating a sustained-release drug composition on the surface of the intraocular lens, and the sustained-release drug composition comprises a degradable polymer, a drug and an organic solvent. The spin-coating technology is applied, the drug sustained-release coating has the special concentric ring pattern with the thin center and the thick periphery, the influence on refraction, stability and foldability of the intraocular lens is small, and the drug sustained-release coating is not prone to falling off and can be stably attached to the surface of the intraocular lens, through drug reasonable selection, the intraocular lens can be used for effectively preventing various common complications after cataract phacoemulsification surgery, such as posterior capsular opacity, intraocular inflammation and other postoperative inflammatory reactions, and the surgery effect is guaranteed.

Description

technical field [0001] The invention relates to the field of ophthalmic medical implant materials and device surface modification, in particular to a foldable intraocular lens with a concentric ring pattern degradable coating surface modification and a preparation method thereof. Background technique [0002] Cataract is the most common blinding eye disease worldwide. At present, the only effective method for the clinical treatment of cataract is phacoemulsification combined with intraocular lens implantation. However, there are still some postoperative complications in modern cataract surgery, such as posterior capsule opacity and endophthalmitis, which affect the recovery of postoperative visual acuity, or lead to severe postoperative visual acuity loss or even blindness. Posterior capsule opacification is a common complication of modern cataract surgery and often occurs months or years after surgery. Affected by factors such as patient age, diabetes mellitus, lens nucle...

Claims

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Application Information

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IPC IPC(8): A61F2/16A61M31/00
CPCA61F2/16A61M31/002A61M2210/0612A61F2240/001A61M2210/005
Inventor 林全愧陆朵朵王家豪
Owner WENZHOU MEDICAL UNIV
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