Application of pirfenidone in preparation of medicaments for controlling proliferative diseases after ophthalmologic operation and eye drops thereof

Abstract

The invention discloses an application of pirfenidone in the preparation of medicaments for controlling proliferative diseases after an ophthalmologic operation and eye drops thereof. According to the invention, pirfenidone is prepared into the eye drops. Experiments show that pirfenidone has good stability and good ocular tissue permeability, can inhibit HLECs migration and propagation, and has no cytotoxicity to HLECs within the action range (0-1mg / ml). With pirfenidone being within the range of 0-1%, the eye drops are continuously applied on eyes within a month with safety and with no obvious toxic and side effect. Pirfenidone can be used to delay the generation of PCO after the rabbit corneal Phaco operation, reduce HLECs propagation and minimize the shield of PCO to an optical region. In addition, there is no obvious ocular surface injury or postoperative inflammation aggravation and severe adverse reaction after PFD is applied in the rabbit corneal Phaco operation. Therefore, pirfenidone can be used to control proliferative diseases after an ophthalmologic operation, especially posterior capsule opacification generated after a cataract surgery.

Description

Technical field: [0001] The invention belongs to the field of medicines for preventing and treating ophthalmic diseases, and specifically relates to the application of pirfenidone in preparing medicines for preventing and treating proliferative diseases after ophthalmic surgery, especially opacity of the posterior lens capsule after cataract surgery, and eye drops. Background technique: [0002] Cataract is the number one blinding eye disease in the world. Cataract prevention and treatment is a key project in the prevention and treatment of blindness and public health, which has significant practical significance. At present, the prevention and treatment of cataract is mainly based on surgical treatment-extracapsular cataract extraction or phacoemulsification and cataract extraction combined with intraocular lens implantation. With the improvement of surgical technology and the continuous development of surgical instruments, the success rate and the quality of cataract surgery h...

AI Technical Summary

Problems solved by technology

With the improvement of surgical techniques and the continuous development of surgical instruments, the success rate of cataract surgery and the quality of sight recovery have been greatly improved. Most cataract patients can recover their sight through surgery. , PCO, that is, post-occurrence cataract) has caused varying degrees of visual obstruction to patients, and has become the biggest factor affecting the recovery of visual function in cataract patients after surgery.

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