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Non-steroid anti-inflammatory medicine for external use for ophthalmology

A non-steroidal anti-inflammatory, ophthalmic technology, applied in the direction of anti-inflammatory agents, antipyretics, drug combinations, etc., can solve problems such as inability to be used externally to the eye, and achieve the effect of less toxic side effects and strong penetrating power

Active Publication Date: 2011-05-18
GUANGDONG WHOLEWIN TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral tablets and suppositories of tiaprofenac and its salts currently in use cannot be used directly or after simple processing for external ocular use

Method used

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  • Non-steroid anti-inflammatory medicine for external use for ophthalmology
  • Non-steroid anti-inflammatory medicine for external use for ophthalmology
  • Non-steroid anti-inflammatory medicine for external use for ophthalmology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0023] Embodiment 1-3 Preparation of tiaprofen acid and its salt eye drops raw material components and consumption

[0024]

[0025] According to the technical scheme of the present invention, the optional auxiliary material kind for preparing tiaprofen acid and its salt eye drops is not limited to the kind listed in the above table, and can also have the following multiple options:

[0026] Bacteriostatic agent: except phenylmercuric nitrate, any bacteriostatic agent known in pharmacy can be used, and its dosage is according to the conventional dosage in pharmacy. For example, ① thimerosal 0.002% to 0.005% (volume-weight percentage, that is, the number of grams per 100 ml, the same below); The effective concentration is 0.002% to 0.01%; ③alcohols, commonly used chlorobutanol 0.3~0.6%; ④parabens, commonly used ethylparaben, concentration 0.03~0.06%; The concentration is 0.01-0.08%.

[0027] Thickener: thickeners commonly used in pharmacy can be used, such as any one or al...

Embodiment 4-6

[0030] Example 4-6 Preparation of tiaprofen acid and its saline ophthalmic gel raw material components and dosage

[0031]

[0032] According to the technical scheme of the present invention, the optional auxiliary materials for preparing tiaprofen acid and its salt ophthalmic gel are not limited to the varieties listed in the above table, and can also have the following multiple options:

[0033] Wherein, the kind selection and consumption of antibacterial agent are the same as embodiment 1~3.

[0034] The thickener is selected from hypromellose, methylcellulose, sodium hyaluronate, polyvinyl alcohol, polycarbophil, polyvinylpyrrolidone, carboxymethylcellulose, carbomer, chondroitin sulfate or Any combination of the varieties; the dosage ratio of the thickener to tiaprofen acid and its salt is 0.5-5 grams: 0.1-1.0 grams.

[0035] Use a pH regulator to adjust the pH value of the finished eye drops to 5.5 to 7.5; the pH regulator is any one of sodium hydroxide, hydrochloric...

Embodiment 7-9

[0037] Embodiment 7-9 Preparation of tiaprofen acid and its salt eye ointment raw material components and dosage

[0038]

[0039] Preparation method: the eye ointment is prepared by the production method of eye ointment commonly used in pharmacy. Its production method is to take tiaprofen acid and its salt, add appropriate amount of sterilized and cooled liquid paraffin, grind it into a fine paste, pass through a 200-mesh sieve, and then gradually add sterile and filtered lanolin and yellow petrolatum mixture , mix well, and you get it. All preparation equipment and packaging containers used must be sterilized.

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Abstract

The invention relates to a eye gel. The content of tiaprofenic acid or the salts thereof in every 100 weight parts of the medicine is 0.1-1.0 weight parts. The non-steroid anti-inflammatory medicine for external use for ophthalmology has good permeability in eyes and low toxic and adverse effects, and can be used for treating and preventing diseases of outer eye and anterior segment of eye, caused by non-infectious inflammations, such as blepharitis, conjunctivitis, keratitis, sclerotitis, episcleritis, iridocyclitis and postoperative inflammation.

Description

technical field [0001] The invention relates to a medical preparation, especially an external medicine for treating non-infectious inflammation in ophthalmology. Background technique [0002] External eye and anterior segment diseases caused by non-infectious inflammation, such as blepharitis, conjunctivitis, keratitis, scleritis, superficial scleritis, iridocyclitis, postoperative inflammation, etc., usually manifest as anterior chamber flare, Conjunctival hyperemia, tearing, photophobia, anterior chamber fibrinous exudation, miosis, iris hyperemia and other inflammatory manifestations. Due to the existence of the "blood-ocular barrier" in the human body, it is difficult to apply systemic medication to non-infectious inflammation of the eye. Topical application of non-steroidal anti-inflammatory drugs to the eye is an effective way to treat inflammation of the outer eye and anterior segment. Currently commonly used ophthalmic non-steroidal anti-inflammatory drugs are indom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/381A61P29/00
Inventor 叶成添吴绮峰王延东
Owner GUANGDONG WHOLEWIN TECH
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