Pharmaceutical compositions from carapa guianensis

A composition and medicine technology, applied in the field of tetranortriterpenoids, can solve problems such as no analgesic activity and the like

Inactive Publication Date: 2007-08-15
FUNDACAO OSWALDO CRUZ FIOCRUZ
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, the synergistic composition of the patent has antispasmodic activity, but it has no analgesic activity

Method used

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  • Pharmaceutical compositions from carapa guianensis
  • Pharmaceutical compositions from carapa guianensis
  • Pharmaceutical compositions from carapa guianensis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Extract preparation

[0090] (a) Oil of Neem Guyana

[0091] The oil of Carapa guianensis used in the present invention is obtained by mechanical pressing of the seeds. When used in experiments, heat aliquots of oil at 40 °C until they are completely melted and dilute in sterile saline solution and Tween 20 at a ratio of 1 μL Tween / mg total mass. When preparing therapeutic solutions, the oil needs to be heated. To ensure the chemical stability of the product, each aliquot of oil was heated at 40°C at least twice.

[0092] (b) Tetranortriterpenoids

[0093] The tetranortriterpenoids of the present invention can be obtained from the oil of the oleifera oleifera or the residue of the seeds of the oleracea oleifera. The methods used in each case are conventional methods.

[0094] The oil of Oleifera oleifera was extracted with acetonitrile in three steps—minimum, stirred and decanted, and the supernatant collected. The supernatant was filtered and evaporated in a rota...

Embodiment 2

[0099] Preparation of Solutions, Drugs and Formulations

[0100] Solutions, drugs and formulations used in this experiment were prepared as described below.

[0101] (a) Preparation of drug

[0102] Promethazine chloride was soaked in tablets (Aventis), weighed and dissolved in a sterile solution of 0.9% NaCl prepared immediately before use. Cyproheptadine (Sigma) was dissolved in water. Sulpyrine was diluted and diclofenac was dissolved in fresh water (0.22 μm). Dexamethasone (Sigma), WEB 2170 (Boehringer-Ingelheim) and HOE 140 (Sigma) were dissolved in sterile NaCl (0.9%) solution. Promethazine cream (Rhodia Farma) was applied directly to the animal's paw.

[0103] All drugs are prepared immediately before use.

[0104] (b) Preparation of solution

[0105] brine

[0106] NaCl 0.9g

[0107] Distilled water (appropriate amount to) 100.00mL

[0108] Adjust pH to 7.2-7.4

[0109] heparinized saline

[0110] Saline 100.00mL

[0111] Heparin 2,000UI

[0112] Adjust pH...

Embodiment 3

[0165] In vivo assay of antiallergic activity of orally administered oil of Carapa guianensis and tetranortriterpenoids.

[0166] For all in vivo methods described below, Swiss male mice, weighing 18 to 25 g, and / or male Wistar rats, weighing 200 to 300 g, were used. The animals were funded by the Central Biotery of Fundac o Provided by Oswaldo Cruz and kept in the biotery of the Laboratório de Farmacologia Aplicada, Far-Manguinhos until use. Animals had free access to water and animal chow and were placed at 25°C with an alternating cycle of light and dark for 12 hours. The animals were treated with repellant (Mebendazole, 20 mg / 1000 mL water) for 3 days and used only for experiments after 3 days interval. All experimental methods were performed in accordance with the Ethics of Animal Experimentation by Fundagao Oswaldo Cruz, RJ.

[0167] a) Experiment of paw edema

[0168] Animals were challenged by intraplantar injections of stimulants (histamine, bradykinin and PAF-pl...

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Abstract

The invention refers to pharmaceutical compositions based on oil extracted from the seeds of Carapa guianensis Aubl and / or tetranortriterpenoid compound separated from the oil and bearing its bioactivity, which has following pharmacological properties: allergy resistance, antiphlogistic activity, acesodyne and immunoregulation, reducing the side effect and lowering the cost. The medicine combination is used to treat and prevent or defend human allergy and inflammatory disease by oral or local treatment. In each case, the compound may be liquid or solid form. The inventive compound for local treatment is nontoxic or low toxicity and provided in a semi-solid type (cream). The inventive medicine combination also provides an important replacement therapy to the allergy disease such as skin and respiratory besides the effects to the different inflammation reaction to the allergen and source of infection. Therefore, the combination can treat rheumatoid, inflammation and modification process, a plurality of hurt, pain and postoperative inflammation, acute pain complex.

Description

[0001] The present invention relates to pharmaceutical compositions based on the oil extracted from the seeds of Carapa Guianensis Aublet and / or on the compounds isolated from this oil and responsible for its biological activity, tetranortriterpenoids . The pharmaceutical composition of the present invention has the following pharmacological activities: anti-allergy, anti-inflammation, analgesic and immune regulation, said compound substantially reduces the occurrence of side effects, and has lower production cost. [0002] The pharmaceutical composition of the present invention is for the treatment, or prevention, or suppression of allergic and inflammatory diseases in humans by oral or topical application. In each case, the compound may be in liquid or solid form. Compounds for topical use may also be in semi-solid form. Compounds of the invention for topical use are non-toxic or of only low toxicity, especially provided in semi-solid form (creams). [0003] Besides having ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/58A61K36/18A61P37/00
CPCA61K47/08A61K9/0095A61K36/58A61K47/44A61K9/0014A61P17/02A61P19/02A61P25/04A61P29/00A61P29/02A61P37/00A61P37/02A61P37/08A61P41/00A61K2300/00
Inventor 玛丽亚·达斯·格雷卡斯·马勒·德奥利维拉·亨里克斯卡梅姆·佩尼多·蒙蒂罗安东尼奥·卡洛斯·西阿尼吉斯莱尼·德法蒂马·吉尔赫米诺莫妮卡·弗赖曼·德索扎·拉莫斯安德烈·卢兹·佛朗哥·萨姆佩奥伊莱恩·克鲁兹·罗莎斯卢西莱内·阿泽维多·德利马雷纳托·贾伯·彭纳福特
Owner FUNDACAO OSWALDO CRUZ FIOCRUZ
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