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Flexible electrode probe for long-term implantation and its preparation method and device

A flexible electrode and probe technology, applied in the fields of application, medical science, diagnosis, etc., can solve problems such as troubles and loss of life of electrode implanters, and achieve reduction of mechanical loss, inhibition of infection and postoperative inflammatory response, and high-efficiency recording Effect

Active Publication Date: 2022-03-25
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, the infection and postoperative inflammation introduced during the operation have been bothering researchers all over the world, and some people with electrode implants even lost their lives because of this.

Method used

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  • Flexible electrode probe for long-term implantation and its preparation method and device
  • Flexible electrode probe for long-term implantation and its preparation method and device
  • Flexible electrode probe for long-term implantation and its preparation method and device

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preparation example Construction

[0065] figure 1 It is a schematic flowchart of a method for preparing a flexible electrode probe for long-term implantation provided by the embodiment of the present application. Such as figure 1 As shown, the embodiment of the present application provides a method for preparing a flexible electrode probe for long-term implantation at least including:

[0066] S100, acquiring an initial flexible electrode probe;

[0067] Wherein, the initial flexible electrode probe includes an elastic insulating layer, a first electrode layer, an elastic barrier layer and a second electrode layer; the second electrode layer is at least arranged at the position of the through hole in the elastic barrier layer, and the The second electrode layer includes a hidden part and an exposed part connected to each other, the hidden part of the second electrode layer is in contact with the electrode contact point in the first electrode layer through the through hole, and the second electrode The expos...

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Abstract

The present application discloses a flexible electrode probe for long-term implantation and its preparation method and equipment. The method at least includes: obtaining an initial flexible electrode probe; at least exposing the second electrode layer in the initial flexible electrode probe A conductive modification layer is formed on the surface of the portion; the material of the conductive modification layer includes a biocompatible conductive polymer; at least a drug-coated biomaterial protective layer is formed on the surface of the conductive modification layer and the surface of the elastic insulating layer, and the Flexible electrode probes for long-term implantation. The technical solution provided by this application can achieve the characteristics of high-efficiency recording and / or stimulation and long-term stability in vivo, and effectively inhibit intraoperative infection and postoperative inflammatory response.

Description

technical field [0001] The present invention This application relates to the technical field of biological electrodes, in particular to a flexible electrode probe for long-term implantation and its preparation method and equipment. Background technique [0002] In the field of biological science research, biological monitoring plays an important role in the scientific research and diagnosis of various organs. Taking brain science as an example, EEG monitoring plays an irreplaceable role in brain science research, brain disease diagnosis and brain-computer interface technology development. The method for collecting EEG signals mainly relies on brain electrodes. At present, there are three types of brain electrodes widely used: scalp brain electrodes (EEG), cortical brain electrodes (ECoG) and intracranial brain electrodes (LFP, Spikes). . The main difference between these three types of electrodes is that the detection parts are different, so that the frequency and signal r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/262A61B5/293A61B5/268
CPCA61B5/6848A61B2562/16A61B2562/12A61B2562/125A61B2562/164
Inventor 陶虎周渝魏晓玲周志涛杨会然
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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