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Neoangiogenesis is the mechanism in cancer that permits the creation of new blood vessels to supply cancerous tumours and ensure their growth. Neoangiogenesis only refers to this phenomenon in cancer, since angiogenesis is the mechanism responsible for the formation of blood vessels throughout the human body (except in tumours).
A bispecific antibody with inflammatory microenvironment regulation function and inhibition of choroidal angiogenesis and its application
The application discloses a dual-specific antibody with functions of inflammation microenvironment regulation and simultaneous inhibition of choroidal neovascularization, and a preparation method and application thereof. The dual-specific antibody is a single-chain antibody, comprises an IL1R, an IL-1 receptor complex auxiliary subunit IL-1RAcP fragment, and extracellular domains D2 (VEGFR2D2) and D3 (VEGFR2D3) of a tyrosine kinase transmembrane receptor VEGFR2, can simultaneously bind to IL-1 and VEGF, has functions of regulating an inflammation microenvironment and inhibiting choroidal neovascularization, and can more accurately treat fundus-related diseases represented by age-related macular degeneration.
Owner:杨洋 +1