Gingko leaf slow-releasing table and preparation process thereof

A technology of Ginkgo biloba and sustained-release tablets, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, can solve the problems of affecting the curative effect of Ginkgo biloba, fluctuations in blood drug concentration, and no sustained-release effect, etc. Long-lasting effect, stable blood concentration and rapid extraction

Inactive Publication Date: 2002-10-02
YABAO PHARMA GRP CO LTD
View PDF0 Cites 33 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs can play a role in the treatment of cerebral thrombosis or cerebral embolism, because they have no sustained-release effect, the number of administrations is many, which brings inconvenience to the patient, and easily causes fluctuations in blood drug concentration, which affects the effect of ginkgo biloba. drug efficacy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take the raw materials according to the following weight ratio:

[0018] Ginkgo biloba extract 120 parts Hydroxypropyl methylcellulose (HPMC) 80 parts

[0019] Lactose 50 parts Starch 30 parts

[0020] 2 parts of magnesium stearate 0.8 parts of absolute ethanol.

[0021] The preparation method of Ginkgo biloba sustained-release tablet is: it is made up of following steps:

[0022] 1), preparation of Ginkgo biloba extract: take dry Ginkgo biloba, test, wash and pulverize it and add it to the reflux reaction tank, add 50% ethanol whose weight is 5 times that of Ginkgo biloba, reflux for 2 hours, concentrate the medicinal solution, and then Use 10% sodium hydroxide to adjust the pH value of the liquid to 8.5, and then reverse the pH value to 6 with 0.5mol / L hydrochloric acid. After separating and concentrating through the mixed column of macroporous adsorption resin (D101) and polyamide resin, then Eluting with water, 20% ethanol and 70% ethanol in sequence, then desorb...

Embodiment 2

[0026] Take the raw materials according to the following weight ratio:

[0027] Ginkgo biloba extract 120 parts Hydroxypropyl methylcellulose (HPMC) 100 parts

[0028] Lactose 80 parts Starch 80 parts

[0029] 5 parts of magnesium stearate 1.2 parts of absolute ethanol.

[0030] The preparation method of Ginkgo biloba sustained-release tablet is: it is made up of following steps:

[0031] 1), preparation of Ginkgo biloba extract: take dried Ginkgo biloba, test, wash and pulverize it and add it to the reflux reaction tank, add 50% ethanol whose weight is 7 times that of Ginkgo biloba, reflux for 2 hours, concentrate the medicinal solution, and then Use 10% sodium hydroxide to adjust the pH value of the medicinal solution to 9.5, and then use 0.5mol / L hydrochloric acid to reverse the pH value to 7. After separating and concentrating through the mixed column of macroporous adsorption resin (D101) and polyamide resin, then Eluting with water, 20% ethanol and 70% ethanol in sequ...

Embodiment 3

[0035] Take the raw materials according to the following weight ratio:

[0036] Ginkgo biloba extract 120 parts Hydroxypropyl methylcellulose (HPMC) 90 parts

[0037] 60 parts of lactose, 50 parts of starch

[0038] 4 parts of magnesium stearate 1 part of absolute ethanol.

[0039] The preparation method of Ginkgo biloba sustained-release tablet is: it is made up of following steps:

[0040] 1), preparation of Ginkgo biloba extract: take dried Ginkgo biloba, test, wash and pulverize it, add it to the reflux reaction tank, add 50% ethanol whose weight is 6 times that of Ginkgo biloba, reflux for 2 hours, concentrate the medicinal solution, and then Use 10% sodium hydroxide to adjust the pH value of the liquid to 7.0, and then reverse the pH value to 6.5 with 0.5mol / L hydrochloric acid. After separating and concentrating through the mixed column of macroporous adsorption resin (D101) and polyamide resin, then Eluting with water, 20% ethanol and 70% ethanol in sequence, then d...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The preparation method of ginkgo leaf slow-released tablet mainly for curing cerebrovascular disease includes the following steps: 1. preparing gingko leaf extract; and 2. preparing slow-released tablet: using gingko leaf extract 120 portions, hydroxypropyl methyl cellulose 80-100 portions, lactose 50-80 portions and starch 30-80 portions, mixing them uniformly, adding anhydrous ethanol 0.8-1.2 portions to make granulation, then adding magnesium stearate 2-5 portions, uniformly mixing them and tabletting to obtain said invented product.

Description

1. Technical field: [0001] The invention relates to a ginkgo leaf sustained-release tablet and a preparation method thereof, which belong to a sustained-release tablet made of Chinese medicinal materials and auxiliary materials and a preparation method thereof. 2. Background technology: [0002] Cerebrovascular diseases are common and frequently-occurring diseases, and the most common clinical types are cerebral thrombosis and cerebral embolism. With the continuous improvement of people's living standards, the incidence of the disease is increasing year by year, seriously threatening human health. The cause of the disease is mostly cerebral atherosclerosis, often mixed with high blood pressure, which is particularly prone to cerebral thrombosis or cerebral embolism. In order to prevent and treat this disease, people have developed many medicines, and the oral liquid and capsule of ginkgo biloba are one of them. Although these drugs can play a role in the treatment of cereb...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P9/10
Inventor 任武贤李亚政杨武王辉轩卫银波
Owner YABAO PHARMA GRP CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap