Eye drops containing tafluprost and preparation method thereof
A technology of tafluprost and eye drops, applied to medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., which can solve the problem of unstable intraocular pressure effects, inaccurate doses, and increased risks of inducing toxic and side effects And other issues
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[0011] The inventors have found in their research that using the hydrophilic polymer polycarbophil AA-1 or carbomer as an eye drop sustained-release material, which is in the form of an aqueous solution in an in vitro environment, when dripped into the conjunctival sac, Affected by the temperature, pH or ionic strength of the eye, it quickly forms a gel and attaches to the surface of the eyeball, forming a very thin layer of drug storage, which can not only increase the retention time of the drug in the eye, avoid the rapid loss of the drug, and The formed drug depot has the effect of slowly releasing the drug, avoiding the rapid elimination of the drug, and improving the bioavailability.
[0012] The invention provides an eye drop containing tafluprost, which comprises the active ingredient tafluprost and a hydrophilic polymer, wherein the hydrophilic polymer is selected from polycarbophil or carbomer.
[0013] In some embodiments, according to the total weight percentage, th...
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