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Preparation method of test sample of musk Baoxinwan slow release gel for pharmacological research

A technology of Shexiang Baoxin Pills and slow-release gel, which is applied in the field of medicine, can solve the problems of inability to realize local administration in animal models, and achieve the effects of promoting angiogenesis, reducing the number of administrations, and high bioavailability

Active Publication Date: 2016-07-06
HEHUANG PHARMA SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical application of "Shexiang Baoxin Pill" is a microparticle pill, which is taken orally three times a day, and local administration in this animal model cannot be achieved.

Method used

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  • Preparation method of test sample of musk Baoxinwan slow release gel for pharmacological research
  • Preparation method of test sample of musk Baoxinwan slow release gel for pharmacological research
  • Preparation method of test sample of musk Baoxinwan slow release gel for pharmacological research

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Put 45 mg of commercially available Shexiang Baoxin Pills (Shanghai Hehuang Pharmaceutical Co., Ltd., batch number 150415) into a mortar and grind them into fine powder. The fineness of the powder of Shexiang Baoxin Pills is <120 mesh. Then add 30 mg of racemic polylactic acid (PLA) and mix, vortex at room temperature for 15 minutes at a rate of 1750 rpm to disperse the particles evenly, then add 110 mg of dimethyl sulfoxide, and extract by ultrasonic at 25°C and extraction power of 240W After 8 hours, the Shexiang Baoxin Pill sustained-release gel sample 1# was obtained. Shexiang Baoxin Pill Sustained-release Gel Sample 1# is a transparent semi-solid brown preparation. In the prepared Shexiang Baoxin pill sustained-release gel sample 1#, by weight percentage, the powder of Shexiang Baoxin pill was 24.3%, the content of racemic polylactic acid was 16.2%, and the content of dimethyl sulfoxide was 59.5%.

Embodiment 2

[0050] Put 45 mg of commercially available Shexiang Baoxin Pills (Shanghai Hehuang Pharmaceutical Co., Ltd., batch number 150415) into a mortar and grind them into fine powder. The fineness of the powder of Shexiang Baoxin Pills is <120 mesh. Then add 30 mg of racemic polylactic acid (PLA) and mix, vortex at room temperature at a rate of 1500-2000 rpm for 10-20 minutes to disperse the particles evenly, then add 102.8 mg of N-methylpyrrolidone, extract at 25 ° C, power Ultrasonic extraction at 240W for 8 hours to obtain Shexiang Baoxin Pill sustained-release gel sample 2#. Shexiang Baoxin Pill Sustained-release Gel Sample 2# is a transparent semi-solid brown preparation. In the prepared Shexiang Baoxin pill sustained-release gel sample 2#, by weight percentage, the powder of Shexiang Baoxin pill was 25.3%, the content of racemic polylactic acid was 16.9%, and the content of N-methylpyrrolidone was 57.8%.

Embodiment 3

[0052] Put 45 mg of commercially available Shexiang Baoxin Pills (Shanghai Hehuang Pharmaceutical Co., Ltd., batch number 150415) into a mortar and grind them into fine powder. The fineness of the powder of Shexiang Baoxin Pills is <120 mesh. Then add 30 mg of racemic polylactic acid (PLA) and mix, vortex at room temperature at a rate of 1500-2000 rpm for 10-20 minutes to disperse the particles evenly, then add 55 mg of dimethyl sulfoxide and 50 mg of water, at 25 ° C, Ultrasonic extraction at 240W for 8 hours to obtain Shexiang Baoxin Pill sustained-release gel sample 3#. Shexiang Baoxin Pill Sustained Release Gel Sample 3# is a transparent semi-solid brown preparation. In the prepared Shexiang Baoxin pill sustained-release gel sample 3#, by weight percentage, Shexiang Baoxin pill powder is 25.0%, racemic polylactic acid is 16.7%, dimethyl sulfoxide and water are 58.3%.

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Abstract

The invention belongs to the technical field of medicine and relates to a preparation method of a test sample of a musk Baoxinwan slow release gel for pharmacological research. The invention also provides a musk Baoxinwan slow release gel, prepared from the following components in percentage by weight: 0.1-30% of musk Baoxinwan powder, 0.9-30% of gel matrix agent and 40-99% of solvent. The invention further provides a preparation method of the musk Baoxinwan slow release gel and an application thereof in preparing a medicine for promoting angiogenesis. The invention also further provides an application of the musk Baoxinwan slow release gel in preparing a medicine for carrying out research on the mechanism of musk Baoxinwan in treating angiogenesis on in vitro animal models. The preparation method of the test sample of the musk Baoxinwan slow release gel for pharmacological research provided by the invention can ensure stable and lasting release of medicine, enables the medicine to play an effect on promoting therapeutic angiogenesis to the utmost extent, and provides a new dosage form for pharmacological research on the musk Baoxinwan.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a method for preparing a test sample of Shexiang Baoxin Pill sustained-release gel used in pharmacological research, in particular to a Chinese medicine compound preparation Shexiang Baoxin Pill for topical administration. Drug sustained-release gel and preparation method thereof. Background technique [0002] "Shexiang Baoxin Pill" is the exclusive product of Shanghai Hutchison Pharmaceutical Co., Ltd. It is a traditional Chinese medicine compound preparation clinically used to treat myocardial infarction, chest obstruction caused by qi stagnation and blood stasis, and angina pectoris caused by myocardial ischemia. make a significant contribution to treatment. "Shexiang Baoxin Pills" has carried out a series of modernization research on traditional Chinese medicine since its listing, including material basis and mechanism of action research, modern pharmacological research, post...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K36/54A61P9/00A61K35/55A61K35/413A61K35/65A61K31/045
Inventor 张建革赵益然周俊杰詹常森
Owner HEHUANG PHARMA SHANGHAI
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