Preparation method of test sample of musk Baoxinwan slow release gel for pharmacological research
A technology of Shexiang Baoxin Pills and slow-release gel, which is applied in the field of medicine, can solve the problems of inability to realize local administration in animal models, and achieve the effects of promoting angiogenesis, reducing the number of administrations, and high bioavailability
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[0047] Example 1
[0048] Put 45 mg of commercially available Shexiang Baoxin Pills (Shanghai Hutchison Pharmaceutical Co., Ltd., batch number 150415) into a mortar and grind into a fine powder. The powder of Shexiang Baoxin Pills has a fineness of less than 120 mesh. Then add 30 mg of racemic polylactic acid (PLA) and mix, vortex and oscillate the particles at a rate of 1750 rpm for 15 minutes at room temperature to make the particles uniformly dispersed, then add 110 mg of dimethyl sulfoxide, and extract ultrasonically at 25°C and an extraction power of 240W In 8 hours, the Shexiang Baoxin Pill sustained-release gel sample 1# was obtained. Shexiang Baoxin Pill sustained-release gel sample 1# is a transparent semi-solid brown preparation. In the prepared Shexiang Baoxin Pill sustained-release gel sample 1#, in terms of weight percentage, the Shexiang Baoxin Pill powder is 24.3%, racemic polylactic acid is 16.2%, and dimethyl sulfoxide is 59.5%.
Example Embodiment
[0049] Example 2
[0050] Put 45 mg of commercially available Shexiang Baoxin Pills (Shanghai Hutchison Pharmaceutical Co., Ltd., batch number 150415) into a mortar and grind into a fine powder. The powder of Shexiang Baoxin Pills has a fineness of less than 120 mesh. Then add 30mg of racemic polylactic acid (PLA) and mix, vortex and oscillate between 10-20min at a rate of 1500-2000rpm at room temperature to make the particles uniformly dispersed. Then add 102.8mg of N-methylpyrrolidone, at 25℃, extraction power Ultrasonic extraction at 240W for 8 hours to obtain Shexiang Baoxin Pill sustained-release gel sample 2#. Shexiang Baoxin Pill sustained-release gel sample 2# is a transparent semi-solid brown preparation. In the prepared Shexiang Baoxin Pill sustained-release gel sample 2#, in terms of weight percentage, the Shexiang Baoxin Pill powder is 25.3%, the racemic polylactic acid is 16.9%, and the N-methylpyrrolidone is 57.8%.
Example Embodiment
[0051] Example 3
[0052] Put 45 mg of commercially available Shexiang Baoxin Pills (Shanghai Hutchison Pharmaceutical Co., Ltd., batch number 150415) into a mortar and grind into a fine powder. The powder of Shexiang Baoxin Pills has a fineness of less than 120 mesh. Then add 30mg of racemic polylactic acid (PLA) and mix, vortex and oscillate between 10-20min at 1500-2000rpm at room temperature to make the particles uniformly dispersed, then add 55mg of dimethyl sulfoxide and 50mg of water, at 25℃, The extraction power was 240W ultrasonic extraction for 8 hours, and the Shexiang Baoxin Pill sustained-release gel sample 3# was obtained. Shexiang Baoxin Pill sustained-release gel sample 3# is a transparent semi-solid brown preparation. In the prepared Shexiang Baoxin Pill sustained-release gel sample 3#, in terms of weight percentage, the Shexiang Baoxin Pill powder is 25.0%, the racemic polylactic acid is 16.7%, and the dimethyl sulfoxide and water are 58.3%.
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