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Phenylsulfonic acid amido chloro diping dispersion tablet and its preparation method

A technology of amlodipine besylate and amlodipine besylate, which is applied in the field of pharmaceuticals, can solve the problems that amlodipine besylate dispersible tablets have not yet been listed on the market, achieve good clinical application prospects, effectively reduce blood pressure, and take convenient effect

Inactive Publication Date: 2005-10-26
YUNNAN BAIYAO GRP HEALTH PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But do not see amlodipine besylate dispersible tablet at home and abroad so far and go on the market

Method used

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  • Phenylsulfonic acid amido chloro diping dispersion tablet and its preparation method
  • Phenylsulfonic acid amido chloro diping dispersion tablet and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: raw material formula:

[0035] Amlodipine besylate 6.93g

[0036] Microcrystalline Cellulose 100.00g

[0037] Anhydrous lactose 30.00g

[0038] Sodium carboxymethyl starch 15.00g

[0039] Micronized silica gel 3.00g

[0040] Magnesium stearate 0.80g

[0041] Preparation method: pulverize amlodipine besylate, pass through a 100-mesh sieve after drying, and set aside; separately pulverize auxiliary materials microcrystalline cellulose, anhydrous lactose, sodium carboxymethyl starch, micropowder silica gel, and magnesium stearate, then dry, Pass through a 100-mesh sieve, and set aside; mix the above-mentioned main ingredients and auxiliary materials uniformly by the method of equal addition, measure the content, find out the theoretical tablet weight after passing the test, directly compress the tablet according to the theoretical tablet weight, and pack it to obtain the product.

Embodiment 2

[0042] Embodiment 2: raw material formula:

[0043] Amlodipine Besylate 6g

[0044] Microcrystalline Cellulose 70g

[0045] Anhydrous lactose 20g

[0046]Sodium carboxymethyl starch 14g

[0047] Micronized silica gel 2g

[0048] Magnesium stearate 0.85g

[0049] The preparation method is prepared according to the method of Example 1.

Embodiment 3

[0050] Embodiment 3: raw material formula:

[0051] Amlodipine Besylate 7g

[0052] Microcrystalline Cellulose 80g

[0053] Anhydrous Lactose 40g

[0054] Sodium carboxymethyl starch 16g

[0055] Micronized silica gel 4g

[0056] Magnesium Stearate 1.0g

[0057] The preparation method is prepared according to the method of Example 1.

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PUM

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Abstract

A dispersing table of amlodipine benzosulfonate for treating hypertension is proportionally prepared from amlodipine benzosulfonate, microcrystalline cellulose, anhydrous lactose, carboxymethyl starch sodium, micropowdered silica gel, and magnesium stearate.

Description

technical field [0001] The invention relates to medicines, in particular to amlodipine besylate dispersible tablets and a preparation method thereof. Background technique [0002] With the improvement of people's living standards and changes in dietary structure and lifestyle, the incidence of hypertension has gradually increased in recent years. Hypertension can cause damage to the heart, brain, kidney and other organs of the patient, and is closely related to sugar and lipid metabolism disorders and diabetes, which can significantly reduce the quality of life of the patient, and even endanger life in severe cases. Therefore, the research on the pathogenesis and therapeutic drugs of hypertension has attracted more and more attention from scholars at home and abroad. [0003] At this stage, the application of antihypertensive drugs is no longer limited to simply lowering blood pressure, but must also consider reducing blood pressure volatility (BPV), enhancing baroreflex se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422
Inventor 钱锋昌
Owner YUNNAN BAIYAO GRP HEALTH PROD CO LTD
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