Nano emulsion injection of alprostadil and preparation method

A technology of nano-dil and alprostadil, which is applied in the direction of pharmaceutical formula, emulsion delivery, medical preparations containing active ingredients, etc., can solve the problems of poor absorption effect and large milk particles, so as to improve distribution, improve curative effect, The effect of simple and feasible quality control method
CN1872072AInactive Publication Date: 2006-12-06广州中大创新药物研究与开发中心有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
广州中大创新药物研究与开发中心有限公司
Publication Date
2006-12-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

A nano-emulsion injection of prostaglandin E1 contains the nano-emulsion particles of rostaglandin E1, the oil for injection, hydrophilic emulsifier, lipophilic emulsifier, isotonic agent, and stabilizer. Its preparing process and its quality control method are also disclosed.
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Description

technical field

[0001] The present invention relates to a kind of alprostadil injection and preparation method thereof, more specifically, the present invention relates to a kind of alprostadil nanoemulsion injection and preparation method thereof. Background technique

[0002] Alprostadil, also known as prostaglandin E1 (Prostagland E1, PGE1), is a highly active physiologically active substance that can inhibit platelet aggregation, thromboxane A2 generation, atherosclerotic lipid plaque formation and immune complexes. Function, and can expand the pharmacological effect of peripheral and coronary blood vessels, mainly used for the treatment of limb ulcers caused by chronic arterial occlusive disease and April branch rest pain caused by microcirculation disturbance.

[0003] The molecular formula of alprostadil is: C 20 h 34 o 5 , the structural formula is as follows:

[0004]

[0005] PGE1 metabolizes very quickly in the body, and under the action of lung oxidase, 60...

Claims

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