Application of pyridine sulfonamide phosphate compound in preparation of anti-encephaledema medicine

A technology of pyridine sulfonamide phosphate and compound, which is applied to pyridine sulfonamide phosphate compounds or pharmaceutical compositions containing them, in the field of preparation of anti-cerebral edema drugs, and achieves the effect of reducing intracranial pressure

Pending Publication Date: 2022-07-29
SHANGHAI XUNHE PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing drug for the treatment of cerebral edema is mainly mannitol injection, but mannitol injection has obvious defects in clinical use. Insufficient patients generally cannot use mannitol injection to treat cerebral edema

Method used

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  • Application of pyridine sulfonamide phosphate compound in preparation of anti-encephaledema medicine
  • Application of pyridine sulfonamide phosphate compound in preparation of anti-encephaledema medicine
  • Application of pyridine sulfonamide phosphate compound in preparation of anti-encephaledema medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Activity study of the compound of Example 1 on nitroglycerin-induced intracranial hypertension model in experimental rabbits

[0036] Male experimental rabbits were divided into groups according to their body weight: normal control group, model control group, mannitol group (1000mg / kg), torasemide group (10mg / kg), and test drug group (10mg / kg). 4. Animals in each group were anesthetized and fixed. The normal control group was intravenously injected with 0.9% sodium chloride injection 5 mL / kg, and the other groups were given continuous intravenous infusion of nitroglycerin (0.04 mg / kg / min) for 10 minutes to establish models, except for the model control group. In addition to no drug treatment, the other groups were given the corresponding drugs by intravenous injection. The mannitol injection was an aqueous solution with a concentration of 20% (weight percent), and both torasemide and the test drug were administered with normal saline (ie, 0.9%). Sodium chloride injecti...

Embodiment 2

[0039] Activity study of the compound of Example 2 on collagenase IV-induced experimental rabbit cerebral hemorrhage model

[0040] The experimental rabbits were randomly divided into groups according to their gender and weight, which were the normal control group, the model control group, the mannitol injection group, the test drug group, and the combined administration group. The normal control group was intravenously injected with 5 mL / kg of 0.9% sodium chloride injection, and the animals in the other groups were injected subdurally with 1 μL of 0.9% sodium chloride injection containing collagenase IV 0.5 μg / μL for modeling, except for the model control group. In addition to no drug treatment, the other groups were given the corresponding drugs by intravenous injection. The mannitol injection was an aqueous solution with a concentration of 20% (100% by weight), and the test drugs were all administered with normal saline (ie, 0.9% sodium chloride injection). ) is made into the...

Embodiment 3

[0045] The inhibitory activity of the compound of embodiment 3 on Na+, K+, Cl- pump

[0046] Detection of furosemide, torasemide, and serial concentrations of test drugs on porcine kidney Na + -K + -2Cl - Activity in a pump transport model. The concentration of rubidium ions in each group of buffer solutions was detected by atomic absorption spectrometry, and the concentration of each test substance / reference substance on Na was calculated according to the original concentration of RbCl added. + -K + -2Cl - Pump activity, at half effective concentration (EC 50 ) indicates activity.

[0047] The results show that the tested drugs have different degrees of inhibitory activity on Na+-K+-2Cl- pump activity, and have a dose-response relationship, EC 50 The data are shown in Table 3, and the effective rates of compounds I-1, II-1, and III-1 at different concentrations are shown in Table 4.

[0048] The activity of table 3 compounds on Na+-K+-2Cl- pump

[0049]

[0050] T...

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PUM

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Abstract

The invention relates to application of a pyridine sulfonamide phosphate compound or a pharmaceutical composition containing the pyridine sulfonamide phosphate compound in preparation of an anti-encephaledema drug. The pyridine sulfonamide phosphate compound can quickly reduce intracranial pressure, is used for treating encephaledema caused by various reasons and preventing cerebral hernia, is high in safety, has no serious adverse effects such as liver and kidney injury and the like, is expected to become a novel clinical anti-encephaledema medicine, and has a very wide clinical application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the use of a pyridinesulfonamide phosphate compound or a pharmaceutical composition containing the same in the preparation of an anti-cerebral edema medicine. Background technique [0002] Cerebral edema is a very common complication of cerebral apoplexy and craniocerebral injury. It is a histopathological reaction caused by physical, chemical, biological and other exogenous or endogenous harmful factors. Abnormal increase in water content, increase in brain volume, and in severe cases, brain herniation and even death may occur. Cerebral edema is an inevitable pathophysiological process after cerebral hemorrhage, which can lead to secondary brain damage to the brain tissue after hemorrhage. At the same time, due to the increase of extracellular fluid when it occurs, intracranial pressure increases, which in turn damages nerve function, resulting in serious adverse consequences....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/675A61P25/00A61P7/10
CPCA61K31/675A61P25/00A61P7/10
Inventor 魏农农翁志洁金华苏敏
Owner SHANGHAI XUNHE PHARMA TECH CO LTD
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