481 results about "Hepato-renal" patented technology

The invention relates to the technical field of tumor treatment, in particular to an intelligent decision-making system for tumor precise targeted medication based on individual mutation information, which comprises a data processing layer, a variation annotation and function prediction layer, a knowledge base integration layer and a scheme decision-making engine and report visualization module. According to the intelligent decision-making system for tumor precise targeted medication based on individual mutation information, a rule engine and a prediction model are combined, dynamic priority ranking is output, multi-model fusion decision making is achieved, and clinical scene deep adaptation is achieved by predicting primary and secondary drug resistance, calculating liver and kidney function adjusting dosage and generating a combined medication time sequence scheme; through an individualized drug delivery scheme, combination drug use optimization is achieved, a visual clinical report is generated, clinical executable operation is further strengthened, and through algorithm quantification, a dynamic knowledge graph, AI auxiliary decision making and a clinical operation closed loop, the next-generation technical research direction of a tumor precise drug use system can be represented.

The present invention discloses a pharmaceutical composition comprising a circular RNA and a drug delivery carrier. Compared with traditional linear 1 * siRNA and annular 1 * siRNA, the number of repeated series connection of positive-sense strands is increased to include but not limited to two or more, it is accidentally found that the silence effect is remarkably enhanced, the expression level of the PCSK9 gene can be remarkably reduced, and degradation of mRNA of PCSK9 protein is mediated. The nano-particles are used for delivering oligonucleotide, so that the stability is improved, the immunogenicity is reduced, the effects of lowering cholesterol, reducing aortic plaque load and resisting atherosclerosis are improved, and the nano-particles are safe and free of obvious liver and kidney toxicity and have a wide application prospect in the aspect of preparing medicines for treating hypercholesterolemia and coronary heart disease.

The invention belongs to the cross technical field of nanomedicine, tumor treatment and immunotherapy, and particularly provides tumor mitochondria-targeted copper death selective induction nanoparticles, which are prepared by the following preparation method: S1, specifically coupling TPY and MHI through condensation reaction to obtain MTPY; s2, MTPY and copper ions are subjected to complexation, and an MTPY-Cu complex is obtained; and S3, the MTPY-Cu complex and albumin are subjected to self-assembly, and the MTPY-Cu-coated Alb nanoparticles are formed. The dosage of copper is only 1 / 1000 of that of free Cu < 2 + >, and equivalent immune regulation and killing effects can be achieved; primary tumors and distant tumor focuses can be inhibited, and lung metastasis is reduced; immune memory can be induced, and relapse can be prevented; the traditional Chinese medicine composition is combined with cis-platinum to remarkably enhance the curative effect and reverse the induced immunosuppression; the invention has the advantages of high biological safety and no obvious liver and kidney toxicity or hemolytic reaction.

Provided is a pharmaceutical composition, comprising a circular RNA and a drug delivery carrier. It is surprisingly found that compared with conventional linear 1 x siRNAs and circular 1 x siRNAs, increasing the number of tandem repeats in the sense strand to two or more significantly enhances the silencing effect, significantly reduces the expression level of the PCSK9 gene, and mediates the degradation of the PCSK9 protein mRNA. The use of nano-particles for delivering oligonucleotides features improved stability, reduced immunogenicity, improved cholesterol-lowering, aortic plaque load-reducing and anti-atherosclerotic effects, good safety, no significant liver and kidney toxicity, and therefore good prospects in preparing medicaments for treating hypercholesterolemia and a coronary heart disease.

The invention discloses an RGD-click chemical crosslinking siRNA nano-carrier, a preparation method thereof and application of the nano-carrier in preparation of a medicine for treating secondary thyroidism, and belongs to the technical field of medicines.The nano-carrier is RGD-PEG-PLys (N), and the preparation method of the nano-carrier comprises the steps of synthesis of PLys (ss-DBCO), synthesis of RGD-PEG-PLys (N) and the like. According to the application, the nano-carrier is used for preparing siRNA composite nanoparticles; vascular endothelial targeting (RGD), dynamic stability (click crosslinking) and microenvironment responsiveness (disulfide bond) are organically combined for the first time to achieve mutual synergistic interaction, and the effect ceiling of an existing material is broken through; according to the siRNA composite nanoparticle, the silence effect of the PTH gene as long as 70 days can be achieved through single intravenous injection, the PTH inhibition rate is larger than 85%, the siRNA accumulation amount in parathyroid gland tissue is remarkably increased through RGD targeting (8.6 times that of a non-targeting group), the liver and kidney distribution amount is reduced by 60%, and the system toxicity is controllable.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating triple negative breast cancer and application thereof. The traditional Chinese medicine composition is prepared from the following main active ingredients in parts by mass: 20 to 40 parts of radix astragali seu hedysari, 10 to 20 parts of rhizoma curcumae, 10 to 20 parts of herba hedyotidis diffusae, 5 to 15 parts of fructus aurantii immaturus, 5 to 15 parts of radix bupleuri, 5 to 15 parts of radix paeoniae alba and 5 to 15 parts of liquorice root. Animal experiments show that the traditional Chinese medicine composition can significantly inhibit tumor growth and pulmonary metastasis of triple-negative breast cancer tumor-bearing mice, increase the proportion of CD8 + T lymphocytes in blood, reduce the proportion of MDSCs, significantly down-regulate the expression of pro-inflammatory cytokines such as IL-6, IL-1alpha, CXCL1 and GM-CSF in serum, and cooperate with PD-L1 immunotherapy to achieve a synergistic effect. And the whole blood and liver and kidney function indexes are in a normal range. Therefore, the traditional Chinese medicine composition disclosed by the invention can be used for effectively inhibiting the tumor growth and pulmonary metastasis of the triple negative breast cancer, remodeling the immune state of an organism and reducing the release of proinflammatory factors, and is safe, reliable, free of obvious liver and kidney toxicity and blood toxicity and small in side effect.

The invention relates to the technical field of biological medicines, in particular to an iRGD targeted and anti-fibrosis small molecule dual-modified exosome as well as a construction method and application thereof. The exosome utilizes the specific binding penetration enhancement effect of iRGD (the amino acid sequence is CRGDKGPDC) and a fibroblast high-expression integrin receptor, so that the enrichment efficiency of the exosome at a focus part is improved; the anti-fibrosis micromolecule Let-7a-5p can inhibit a TGF-beta signal channel by blocking Smad2 / 3 phosphorylation, and the anti-fibrosis micromolecule Let-7a-5p and the anti-fibrosis microRNA carried by the exosome generate a synergistic anti-fibrosis effect; the exosome phospholipid bilayer can also protect Let-7a-5p from enzymolysis and prolong the half-life period, and iRGD modification can reduce the non-targeted uptake rate. An animal model verifies that the double-modified exosome has a good skin fibrosis resisting effect, and side effects such as liver and kidney function damage are not found. The invention provides an effective and safe treatment scheme for resisting skin fibrosis.

The invention discloses a radionuclide-labeled collagen hybrid peptide probe as well as a preparation method and application thereof. The chemical structural general formula of the radionuclide-labeled collagen hybrid peptide probe is (metal nuclide-chelating agent)-Linker-CHP, wherein the metal nuclide is selected from any one of Al18F, 64Cu, 67Cu, 67Ga, 68Ga, 99mTc, 89Zr, 111In, 177Lu, 186Re and 225Ac, and the metal nuclide is selected from any one of Al18F, 64Cu, 67Cu, 67Ga, 68Ga, 99mTc, 89Zr, 111In, the chelating agent is selected from any one of NODAGA, NOTA2 and DOTA; linker is a connecting joint, and CHP is a collagen hybrid peptide with a polypeptide sequence of (GfO) n or (GPO) n. The probe not only has the characteristic of radiochemical marking stability, but also has the excellent biological distribution characteristics of high uptake in target organs such as tumors and low uptake in non-target organs such as liver and kidney, and has a good clinical application prospect.

The invention discloses a traditional Chinese medicine compound oral preparation for treating male oligoasthenospermia, and belongs to the technical field of traditional Chinese medicine preparations. The rhizoma polygonati processed with wine, the prepared rehmannia root and the like are used for nourishing the liver and kidney to consolidate congenital, the codonopsis pilosula, the astragalus membranaceus and the like are used for invigorating spleen and replenishing qi to complement postnatal, the fried cowherb seed is used for activating blood circulation, and the salted semen plantaginis is used for promoting diuresis, so that the problems of insufficient spermatogenesis and low vitality caused by deficiency of the spleen and the kidney are fundamentally solved. Experiments and clinical researches show that the preparation can significantly improve the sperm quantity, activity and activity rate of oligoasthenospermia model mice and patients, the clinical total effective rate reaches 90%, the pregnancy rate reaches 53.3%, and the curative effect is superior to that of Wuzi Yanzong pills in a control group. The action mechanism covers regulation of blood lipid metabolism, improvement of hypothalamus-pituitary-gonad axis functions, repair of testicular seminiferous tubule structural damage and reduction of lipid deposition, and meanwhile, oxidative stress and inflammatory injury are relieved and spermatogenic cell functions are protected by regulating and controlling a PPAR signal channel and inhibiting molecular pathways such as Cga / Sting mediated cell apoptosis.

The invention relates to a traditional Chinese medicine composition for treating allergic dermatitis. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 5-35 parts of fried coix seeds, 5-35 parts of concha margaritifera, 1-30 parts of honeysuckle stems, 1-30 parts of smoked plums, 1-30 parts of fructus liquidambaris, 1-25 parts of fructus forsythiae, 1-25 parts of radix paeoniae rubra, 1-25 parts of raw sanguisorba officinalis, 1-25 parts of radix glehniae, 1-25 parts of radix ophiopogonis and 1-25 parts of raw radix polygonati officinalis. 1-25 parts by weight of talc and 1-25 parts by weight of lophatherum gracile. The traditional Chinese medicine composition has the effects of clearing heat, cooling blood without bitter cold, dispelling wind, eliminating dampness without hurting stomach, detoxifying, relieving itching and nourishing yin, is safe in clinical use, and has no adverse effect on liver and kidney.

The invention discloses a preparation method and application of a medicinal and edible traditional Chinese medicine compound with an effect of treating uric acid diseases. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 to 25 parts of semen plantaginis, 15 to 25 parts of pawpaw, 5 to 15 parts of rhizoma smilacis glabrae, 5 to 15 parts of herba portulacae, 1 to 11 parts of radix glycyrrhizae preparata, 5 to 15 parts of folium mori, 5 to 15 parts of folium perillae, 1 to 11 parts of semen pruni, 5 to 15 parts of rhizoma polygonati, 1 to 11 parts of black dates and 1 to 9 parts of mulberries. The traditional Chinese medicine compound is composed of medicinal and edible raw materials, has stable efficacy of reducing uric acid and relieving uric acid liver and kidney injury, renal fibrosis and gouty arthritis, can relieve arthrocele caused by gout, reduces the level of joint inflammatory factors and the like, and takes effect quickly. The traditional Chinese medicine composition can be used for treating hyperuricemia, uric acid nephropathy, gouty arthritis and hyperuricemia accompanying symptoms.

The present application relates to a kind of traditional Chinese medicine composition for treating cervical spondylosis and its preparation method and use, belong to the field of traditional Chinese medicine.The traditional Chinese medicine composition of the present application is prepared from the following weight ratio of raw medicinal materials: Huangqi 14.4-21.6 parts, Baishao 14.4-21.6 parts, Jixueteng 14.4-21.6 parts, Gegen 14.4-21.6 parts, Sangzhi 14.4-21.6 parts, Gouqi 7.2-10.8 parts, Tianma 7.2-10.8 parts, Chuanqiong 7.2-10.8 parts, Lingshenteng 7.2-10.8 parts, Zexie 7.2-10.8 parts, Baizhu 7.2-10.8 parts, Sanqi 2.4-3.6 parts.The present application also provides the preparation method and use of the traditional Chinese medicine composition.The present application is aimed at the complex syndrome type of "deficiency of liver and kidney combined with phlegm-dampness blocking meridians cervical spondylosis", introduces Zexie and Baizhu drug pair, and combines water and removes dampness, and has the effect of invigorating spleen and drying dampness, is specially used for treating phlegm-dampness dizziness, and the compatibility of "Tianma" significantly enhances the ability of resolving phlegm, calming wind and stopping dizziness.At the same time, Chuanqiong is introduced to promote blood circulation and qi, and goes up to head and eyes to stop pain, and Jixueteng, Lingshenteng and Gegen form synergistic compatibility, the medicinal property is mild, the curative effect is remarkable, the side effect risk is low, and it is suitable for long-term nursing of cervical spondylosis.

The invention relates to a traditional Chinese medicine composition for treating cervical spondylosis and a preparation method and application thereof, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 14.4 to 21.6 parts of radix astragali seu hedysari, 14.4 to 21.6 parts of radix paeoniae alba, 14.4 to 21.6 parts of caulis spatholobi, 14.4 to 21.6 parts of radix puerariae, 14.4 to 21.6 parts of ramulus mori, 7.2 to 10.8 parts of fructus lycii, 7.2 to 10.8 parts of rhizoma gastrodiae, 7.2 to 10.8 parts of rhizoma chuanxiong, 7.2 to 10.8 parts of radix clematidis, 7.2 to 10.8 parts of rhizoma alismatis, 7.2 to 10.8 parts of rhizoma atractylodis macrocephalae and 2.4 to 3.6 parts of radix notoginseng. The invention further provides a preparation method and application of the traditional Chinese medicine composition. Aiming at a compound syndrome type of liver and kidney deficiency combined with phlegm-damp collateral blocking cervical spondylosis, the rhizoma alismatis and bighead atractylodes rhizome pairs are introduced to achieve the effects of clearing damp, promoting diuresis, tonifying spleen and drying dampness together, and the traditional Chinese medicine is specially used for treating phlegm-damp dizziness and is matched with the rhizoma gastrodiae, so that the effects of reducing phlegm, stopping wind and stopping dizziness are remarkably enhanced. Meanwhile, ligusticum wallichii capable of promoting blood circulation and qi circulation is introduced to move upwards to relieve pain and forms synergistic compatibility with caulis spatholobi, herba clematidis and radix puerariae, and the traditional Chinese medicine composition is mild in medicine property, remarkable in curative effect, low in side effect risk and suitable for long-term nursing of cervical spondylosis.

The invention discloses an application of an eyesight-improving twenty-five-ingredient pill in preparation of a medicine for preventing or treating cataract and complications thereof, the eyesight-improving twenty-five-ingredient pill has obvious effects of clearing heat, cooling blood, improving eyesight and the like, has a good curative effect on cataract, is safe in clinical use, has no influence on hematuria routine, heart and liver and kidney functions before and after medication, and is suitable for clinical application. No obvious adverse reaction is found.

The application discloses a composition for protecting liver and strengthening kidney and reducing uric acid, which is made of the following raw material components: Anoectochilus roxburghii, dried tangerine or orange peel, chicory, gardenia, turmeric, Hovenia dulcis Thunb, Cistanche deserticola Y.C.Ma, Rehmannia glutinosa, potassium citrate, sodium citrate and goose myo-peptide. The composition combines the immortal concept of TCM (Traditional Chinese Medicine) "treating disease from the root" and the uric acid control method of modern nutritional medicine as an organic whole, and achieves multiple effects of protecting liver and strengthening kidney, mutual benefit of yin and yang and reducing uric acid through multiple action targets. Animal experiment results show that the composition can effectively reduce the activities of transaminase ALT and AST, relieve liver damage, reduce serum creatinine level and improve urea ammonia excretion rate, improve kidney function, inhibit the activities of xanthine oxidase and adenosine dehydrogenase and reduce uric acid level. The composition is safe and has no toxic side effects, is suitable for people with insufficient liver and kidney functions and hyperuricemia and has a wide application prospect.

The application discloses application of total flavones of chrysanthemum morifolium ramat and metabolites thereof in preparation of uric acid-lowering or liver and kidney protecting drugs or health care products. The total flavones of chrysanthemum morifolium ramat contain various flavone compounds. In a hyperuricemia model mouse, the total flavones of chrysanthemum morifolium ramat can significantly reduce blood uric acid level, and has a significant protective effect on liver and kidney, and the effect is achieved by inhibiting the activity and expression of xanthine oxidase and adenosine deaminase in the liver, and regulating the expression of uric acid related transporters in the kidney. Meanwhile, metabolites of the total flavones of chrysanthemum morifolium ramat, luteolin-7-O-glucuronide and apigenin-7-O-glucuronide, can also play a pharmacological role in the mouse body. In vitro experiments and mouse primary hepatocytes further prove that luteolin-7-O-glucuronide and apigenin-7-O-glucuronide have an inhibiting effect on the activity and expression level of xanthine oxidase. The application widens the application range of traditional Chinese medicinal materials, and provides a new direction for development of efficient and low-toxic uric acid-lowering and anti-gout drugs or health care products.

The invention belongs to the field of preparation of medicaments for reducing uric acid, and particularly relates to a traditional Chinese medicine composition for reducing uric acid level and a preparation method thereof. Piperine, oat beta-glucan and medium chain triglyceride are mixed to react, a carrier material with a net structure is formed, a uric acid reducing solution obtained through adsorption and fermentation is freeze-dried, and the obtained efficient uric acid reducing component can remarkably and efficiently reduce the uric acid level in an organism; the regulating component is mixed with the metabolism promoting component obtained after powdering, the mixture is put into the coating material which can form a transparent film after being dried, and freeze spray drying is performed to obtain the long-acting agent which can stably play a role in a long-acting manner; the composition for maintaining stability and improving taste is uniformly sprayed on the surface of the traditional Chinese medicine component for reducing the uric acid level, and the prepared traditional Chinese medicine composition for reducing the uric acid level is remarkable and efficient in effect, improved in taste, free of peculiar smell, beneficial to persistent taking and free of irritation to liver and kidney after being taken for a long time.

The invention relates to a preparation method and application of a medicine-food homologous compound with weight-losing and lipid-lowering effects. According to the present invention, the weight of the obese mouse can be reduced by 23.23% at most, the serum total cholesterol is reduced, the leptin secretion is reduced, AST (aspartate transaminase) and ALT (alanine transaminase) have no significant difference compared to the model mouse, the volume of epididymal fat and inguinal fat cells is reduced, the number of cells in unit area is significantly increased, the fatty liver sample is relieved, the TMEM26 gene expression in the epididymal fat is significantly increased, and the weight of the obese mouse can be significantly reduced; the expression quantity of the UCP1 gene in brown fat is obviously increased. The traditional Chinese medicine composition adopts medicinal and edible substances as raw materials, is widely applicable to people, is more suitable for prevention and treatment of chronic diseases, is safe and effective, and causes little damage to liver and kidney after long-term use.

The invention relates to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating Parkinson's disease, namely tremor syndrome of traditional Chinese medicine, which comprises the following raw materials by weight: 390-470g of liver calming and wind calming medicine, 140-160g of radix rehmanniae, 280-320g of radix paeoniae alba, 840-960g of first decoction medicine, 390-450g of blood activating and qi regulating and tendon and collateral dredging medicine, and 305-355g of antidote. The traditional Chinese medicine composition has remarkable effects of relaxing tendons and detoxifying, and calming endogenous wind and arresting fibrillation, can play a role in solving the problems of head shaking, limb tremor, muscle stiffness, dyskinesia and the like caused by liver wind internal movement and kidney deficiency and toxic damage of Parkinson's disease, and can nourish liver and kidney, relieve tendon and vessel contracture and relieve pain due to the synergistic effect of various traditional Chinese medicinal materials contained in the traditional Chinese medicine composition. The traditional Chinese medicine composition is especially suitable for Parkinson patients with liver-wind internal movement and kidney deficiency and toxicity loss, and can gradually improve the neurotransmitter level in the brain after being taken. The traditional Chinese medicine composition has an outstanding detoxification effect, can effectively remove accumulation of pathological products such as phlegm and blood stasis in the body of the Parkinson's disease patient, prevents phlegm and blood stasis from generating toxins, and can relieve medicine poison generated by long-term medicine taking of the patient.

The invention relates to the technical field of critical index monitoring methods, in particular to an intelligent critical index monitoring method and system based on clinical data. According to the method, a standardized data packet is constructed by collecting vital sign data of a patient, an inspection index group, drug intervention parameters and individual characteristics of the patient; calculating an individualized drug metabolism correction coefficient based on the liver and kidney function state and a real-time creatinine value, and dynamically generating a drug influence factor in combination with the flow rate of an analgesia pump; scene classification is carried out according to the medicine influence factor value and the blood pressure change trend, and the alarm weight of each monitoring index is dynamically adjusted; and finally, accurate risk assessment and graded early warning are realized through multi-index fusion analysis. The system comprises a data acquisition function module, a dynamic analysis function module, a weight adjustment function module and an early warning decision function module. The clinical problem that a traditional monitoring system is insufficient in sensitivity to progressive deterioration in a drug interference environment is effectively solved, and a more reliable safety monitoring scheme is provided for postoperative high-risk patients.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a kidney-tonifying and liver-nourishing compound preparation and a preparation method thereof. The compound preparation comprises 5-15 parts of roasted herba epimedii, 5-15 parts of fructus cnidii, 50-70 parts of roasted radix astragali and 10-30 parts of pulp of dogwood fruit. The traditional Chinese medicine composition has remarkable curative effects on various diseases and chronic strain caused by deficiency of liver and kidney and deficiency of blood and essence, such as dizziness, blurred vision, fatigue, swelling and pain of waist, back and limbs, dry mouth and eyes, limb ache and weakness, irregular menstruation, incapability of holding weight or hemiplegia and the like, and has a very good application prospect.

The invention belongs to the technical field of medical information, and relates to a drug interaction screening method based on drug use records. The core structure comprises: a data integration module, which obtains a multi-source medication record of a patient in real time through an HL7 / FHIR interface and carries out structured processing; the metabolism engine calculation module is used for identifying a metabolism action mode based on the drug-metabolic enzyme influence relation database and quantifying a net effect value by adopting a dynamic time weighting algorithm; the risk decision module is used for integrating liver and kidney functions and gene polymorphism data and generating a three-dimensional risk matrix through a multi-factor prediction model; and the clinical output module is used for executing risk visualization early warning, alternative medicine recommendation and individualized monitoring scheme generation. Dynamic medication time sequence analysis, individualized risk quantification and clinical decision closed-loop management are realized, and medication safety is improved.

The invention provides a method and device for calculating the liver-kidney ratio of an ultrasonic image, and relates to the technical field of ultrasonic image analysis, and the method comprises the steps: obtaining a target ultrasonic image, carrying out the recognition and segmentation of a liver region and a kidney region in the target ultrasonic image through a pre-constructed cascading convolutional neural network frame, and obtaining the liver-kidney ratio of the target ultrasonic image; obtaining a target liver mask and a target kidney mask; based on predefined ROI (Region of Interest) parameters, filtering the target ultrasonic image, taking pixel points in a filtering result, which are positioned in the target liver mask, as liver ROI selection results, and taking pixel points in the filtering result, which are positioned in the target kidney mask, as kidney ROI selection results; and based on a pixel pair selection result, estimating the liver-kidney ratio of the target ultrasonic image through a statistical method. Through the method provided by the invention, quantitative estimation of the liver-kidney ratio is realized, and errors caused by manual operation of technicians are effectively avoided.

This invention provides a traditional Chinese medicine composition for the prevention and treatment of knee arthritis. The active ingredients, by weight, include: 15-25 parts of Salvia miltiorrhiza, 8-15 parts of Ligusticum chuanxiong, 12-20 parts of Angelica sinensis, 7-15 parts of Lycopus lucidus, 15-30 parts of Poria cocos, 8-15 parts of Placenta hominis, 18-30 parts of Clematis chinensis, 15-25 parts of Spatholobus suberectus, 25-40 parts of Paeonia lactiflora, 12-20 parts of Rehmannia glutinosa, and 8-15 parts of Glycyrrhiza uralensis. Using Salvia miltiorrhiza, Ligusticum chuanxiong, Angelica sinensis, Lycopus lucidus, Poria cocos, Placenta hominis, Clematis chinensis, Spatholobus suberectus, Paeonia lactiflora, Rehmannia glutinosa, and Glycyrrhiza uralensis as raw materials, this invention follows the principle of "principal, assistant, adjuvant, and guide" in traditional Chinese medicine. The combined use of these herbs can tonify the liver and kidneys, promote blood circulation and remove blood stasis, and has a good therapeutic effect on knee arthritis caused by liver and kidney deficiency and qi stagnation and blood stasis.

The invention discloses a pill for treating qi-blood deficiency and a preparation method thereof, and belongs to the technical field of Chinese patent medicine preparation. Comprising 80-90 parts of wall-broken ginseng rootlets, 140-160 parts of freeze-dried Chinese wolfberry fruits, 190-210 parts of fried Chinese yam powder, 110-130 parts of fermented Chinese date powder, 50-70 parts of donkey-hide gelatin beads, 80-100 parts of black sesame seed powder, 45-55 parts of maltitol, 15-25 parts of giant knotweed rhizomes, 10-14 parts of red peony roots and 0.5 part of a compound enzyme preparation. The medicine is small in packaging size, convenient to carry and low in cost; the traditional Chinese medicine composition has the advantages of scientific formula, wide application range, stable process and controllable quality, and embodies the traditional Chinese medicine theory advantages of simultaneous treatment of vital qi and pathogen and simultaneous regulation of qi and blood. Acute toxicity tests show that LD50 is larger than 20 g / kg, and the traditional Chinese medicine is free of liver and kidney dysfunction after being taken for a long time and suitable for long-term conditioning.

The application provides a method for analyzing the synergistic mechanism of hepatotoxicity and nephrotoxicity of non-steroidal anti-inflammatory drugs. The method comprises the following steps: preliminary toxicity prediction of NSAIDs and collection of toxicity target points, collection of liver and kidney disease target points, then cross and screening of the target points to obtain core target points and common core target points of NSAIDs induced liver and kidney diseases, and then constructing a protein interaction network of the common core target points; enrichment analysis of the common core target points to obtain the common action pathway of NSAIDs induced liver and kidney diseases; finally, further screening of the common core target points to obtain the key target points of NSAIDs induced liver and kidney diseases, and verification by using molecular docking technology. Compared with the traditional method, the advantages of the method are: first, the method does not depend on large-scale patient clinical data and a large number of animal or cell experiments, avoiding the ethical controversy in animal experiments and human experiments; second, the method can identify the potential cross-pathway and synergistic toxicity mechanism when a compound triggers multiple diseases, which is helpful for more comprehensive evaluation of the toxicity risk of NSAIDs.

The invention provides a traditional Chinese medicine for treating protrusion of lumbar intervertebral disc, and relates to the technical field of traditional Chinese medicines. Aiming at the core pathogenesis of qi stagnation and blood stasis, deficiency of liver and kidney and cold-dampness arthralgia of the lumbar intervertebral disc protrusion, a synergistic compatibility concept of promoting blood circulation to remove blood stasis, tonifying liver and kidney, dispelling cold-dampness and activating meridians to stop pain is adopted. The traditional Chinese medicine is prepared from 12 traditional Chinese medicines such as ligusticum wallichii, safflower, eucommia ulmoides and radix achyranthis bidentatae through an optimized process of crushing, extracting, concentrating and forming, and the dosage form comprises tablets, capsules or oral liquid. The core innovation lies in accurate matching of the formula, multi-target synergistic effect is achieved, and the problems that traditional Chinese medicine is slow in curative effect and poor in pertinence are solved. Clinical verifications show that the traditional Chinese medicine can relieve lumbar pain within 7 days and improve symptoms such as numbness of lower limbs and limited movement within 1-2 treatment courses, has the total effective rate of greater than or equal to 92%, is safe, has no obvious toxic or side effect, is suitable for patients with different types of lumbar disc herniation, and is convenient to take and high in cost performance.

The application discloses application of white ginseng mushroom in preparation of a medicine for treating hyperuricemia, and belongs to the technical field of deep processing of edible mushrooms. The white ginseng mushroom is vacuum freeze-dried, ground into powder, other traditional Chinese medicine ingredients are extracted, concentrated, and spray-dried into powder; the white ginseng mushroom powder is mixed with sodium carboxymethyl cellulose and guar gum solution to form a mushroom suspension colloid, the microcapsules are collected after being dropped into a calcium-containing aqueous solution; the microcapsules are immersed in a high polymer compound solution for treatment, finally mixed with a stabilizer paste, and then filled after being treated by a high-pressure homogenizer and sterilized. Compared with the prior art, the medicine has good stability in simulated gastric juice, can be quickly released in simulated intestinal juice, significantly improves the bioavailability and curative effect of the medicine, can effectively reduce the serum uric acid level, improve liver and kidney functions, and regulate the intestinal flora structure, and has a significant uric acid-lowering effect and multi-target synergistic effect.

The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 to 25 parts of radix salviae miltiorrhizae, 8 to 15 parts of rhizoma chuanxiong, 12 to 20 parts of radix angelicae sinensis, 7 to 15 parts of herba lycopi, 15 to 30 parts of poria cocos, 8 to 15 parts of human placenta, 18 to 30 parts of herba speranskiae tuberculatae, 15 to 25 parts of caulis spatholobi, 25 to 40 parts of radix paeoniae alba, 12 to 20 parts of radix rehmanniae and 8 to 15 parts of liquorice root. The traditional Chinese medicine composition takes salvia miltiorrhiza, ligusticum wallichii, angelica sinensis, herba lycopi, poria cocos, human placenta, garden balsam stem, caulis spatholobi, radix paeoniae alba, radix rehmanniae and liquorice as raw materials, follows the medication principle of monarch, minister, assistant and guide of traditional Chinese medicines, can tonify the liver and kidney and promote blood circulation to remove blood stasis by combining the medicines, and has a good treatment effect on liver and kidney deficiency and qi stagnation and blood stasis type knee arthralgia.

The invention discloses a traditional Chinese medicine mixture with a liver and kidney tonifying effect and a preparation method thereof, and belongs to the field of pharmaceutical preparations. The traditional Chinese medicine mixture comprises the following components in parts by weight: 45-60 parts of polygonum multiflorum; 45-60 parts of rhizoma polygonati; 110 to 130 parts of fructus rosae laevigatae; 2.4 to 3.2 parts of Chinese angelica; 45-60 parts of rhizoma cibotii; 3.2 to 3.8 of semen cuscutae; 1.8-2.4 parts of dried orange peel; 3.5 parts of fructus psoraleae; the preparation method of the traditional Chinese medicine mixture comprises the following steps: decocting the components in water, filtering, concentrating filtrate until the density is 1.10-1.16 g / mL, adding ethanol until the alcohol content is 60%, standing for 24 hours, taking supernate, filtering, and recovering the filtrate under reduced pressure until no alcohol exists; adding water to 120 parts by weight, adding 2 parts by weight of talcum powder and 1 part by weight of sodium benzoate, uniformly stirring, and standing for 24-48 hours; taking supernatant liquid, adding 120-150 parts by weight of cane sugar, adding water to 300-350 parts by weight, uniformly stirring, boiling, standing and filtering to obtain filtrate, namely the product mixture. Eight medicines of the traditional Chinese medicine mixture are applied dialectically, and complement each other in tonifying liver and kidney, invigorating spleen and replenishing qi, arresting seminal emission and arresting enuresis.