244 results about "Hepato-renal" patented technology

The invention discloses an RGD-click chemical crosslinking siRNA nano-carrier, a preparation method thereof and application of the nano-carrier in preparation of a medicine for treating secondary thyroidism, and belongs to the technical field of medicines.The nano-carrier is RGD-PEG-PLys (N), and the preparation method of the nano-carrier comprises the steps of synthesis of PLys (ss-DBCO), synthesis of RGD-PEG-PLys (N) and the like. According to the application, the nano-carrier is used for preparing siRNA composite nanoparticles; vascular endothelial targeting (RGD), dynamic stability (click crosslinking) and microenvironment responsiveness (disulfide bond) are organically combined for the first time to achieve mutual synergistic interaction, and the effect ceiling of an existing material is broken through; according to the siRNA composite nanoparticle, the silence effect of the PTH gene as long as 70 days can be achieved through single intravenous injection, the PTH inhibition rate is larger than 85%, the siRNA accumulation amount in parathyroid gland tissue is remarkably increased through RGD targeting (8.6 times that of a non-targeting group), the liver and kidney distribution amount is reduced by 60%, and the system toxicity is controllable.

The invention relates to a traditional Chinese medicine composition for treating allergic dermatitis. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 5-35 parts of fried coix seeds, 5-35 parts of concha margaritifera, 1-30 parts of honeysuckle stems, 1-30 parts of smoked plums, 1-30 parts of fructus liquidambaris, 1-25 parts of fructus forsythiae, 1-25 parts of radix paeoniae rubra, 1-25 parts of raw sanguisorba officinalis, 1-25 parts of radix glehniae, 1-25 parts of radix ophiopogonis and 1-25 parts of raw radix polygonati officinalis. 1-25 parts by weight of talc and 1-25 parts by weight of lophatherum gracile. The traditional Chinese medicine composition has the effects of clearing heat, cooling blood without bitter cold, dispelling wind, eliminating dampness without hurting stomach, detoxifying, relieving itching and nourishing yin, is safe in clinical use, and has no adverse effect on liver and kidney.

The application discloses a composition for protecting liver and strengthening kidney and reducing uric acid, which is made of the following raw material components: Anoectochilus roxburghii, dried tangerine or orange peel, chicory, gardenia, turmeric, Hovenia dulcis Thunb, Cistanche deserticola Y.C.Ma, Rehmannia glutinosa, potassium citrate, sodium citrate and goose myo-peptide. The composition combines the immortal concept of TCM (Traditional Chinese Medicine) "treating disease from the root" and the uric acid control method of modern nutritional medicine as an organic whole, and achieves multiple effects of protecting liver and strengthening kidney, mutual benefit of yin and yang and reducing uric acid through multiple action targets. Animal experiment results show that the composition can effectively reduce the activities of transaminase ALT and AST, relieve liver damage, reduce serum creatinine level and improve urea ammonia excretion rate, improve kidney function, inhibit the activities of xanthine oxidase and adenosine dehydrogenase and reduce uric acid level. The composition is safe and has no toxic side effects, is suitable for people with insufficient liver and kidney functions and hyperuricemia and has a wide application prospect.

The application discloses application of total flavones of chrysanthemum morifolium ramat and metabolites thereof in preparation of uric acid-lowering or liver and kidney protecting drugs or health care products. The total flavones of chrysanthemum morifolium ramat contain various flavone compounds. In a hyperuricemia model mouse, the total flavones of chrysanthemum morifolium ramat can significantly reduce blood uric acid level, and has a significant protective effect on liver and kidney, and the effect is achieved by inhibiting the activity and expression of xanthine oxidase and adenosine deaminase in the liver, and regulating the expression of uric acid related transporters in the kidney. Meanwhile, metabolites of the total flavones of chrysanthemum morifolium ramat, luteolin-7-O-glucuronide and apigenin-7-O-glucuronide, can also play a pharmacological role in the mouse body. In vitro experiments and mouse primary hepatocytes further prove that luteolin-7-O-glucuronide and apigenin-7-O-glucuronide have an inhibiting effect on the activity and expression level of xanthine oxidase. The application widens the application range of traditional Chinese medicinal materials, and provides a new direction for development of efficient and low-toxic uric acid-lowering and anti-gout drugs or health care products.

The invention belongs to the field of preparation of medicaments for reducing uric acid, and particularly relates to a traditional Chinese medicine composition for reducing uric acid level and a preparation method thereof. Piperine, oat beta-glucan and medium chain triglyceride are mixed to react, a carrier material with a net structure is formed, a uric acid reducing solution obtained through adsorption and fermentation is freeze-dried, and the obtained efficient uric acid reducing component can remarkably and efficiently reduce the uric acid level in an organism; the regulating component is mixed with the metabolism promoting component obtained after powdering, the mixture is put into the coating material which can form a transparent film after being dried, and freeze spray drying is performed to obtain the long-acting agent which can stably play a role in a long-acting manner; the composition for maintaining stability and improving taste is uniformly sprayed on the surface of the traditional Chinese medicine component for reducing the uric acid level, and the prepared traditional Chinese medicine composition for reducing the uric acid level is remarkable and efficient in effect, improved in taste, free of peculiar smell, beneficial to persistent taking and free of irritation to liver and kidney after being taken for a long time.

The invention relates to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating Parkinson's disease, namely tremor syndrome of traditional Chinese medicine, which comprises the following raw materials by weight: 390-470g of liver calming and wind calming medicine, 140-160g of radix rehmanniae, 280-320g of radix paeoniae alba, 840-960g of first decoction medicine, 390-450g of blood activating and qi regulating and tendon and collateral dredging medicine, and 305-355g of antidote. The traditional Chinese medicine composition has remarkable effects of relaxing tendons and detoxifying, and calming endogenous wind and arresting fibrillation, can play a role in solving the problems of head shaking, limb tremor, muscle stiffness, dyskinesia and the like caused by liver wind internal movement and kidney deficiency and toxic damage of Parkinson's disease, and can nourish liver and kidney, relieve tendon and vessel contracture and relieve pain due to the synergistic effect of various traditional Chinese medicinal materials contained in the traditional Chinese medicine composition. The traditional Chinese medicine composition is especially suitable for Parkinson patients with liver-wind internal movement and kidney deficiency and toxicity loss, and can gradually improve the neurotransmitter level in the brain after being taken. The traditional Chinese medicine composition has an outstanding detoxification effect, can effectively remove accumulation of pathological products such as phlegm and blood stasis in the body of the Parkinson's disease patient, prevents phlegm and blood stasis from generating toxins, and can relieve medicine poison generated by long-term medicine taking of the patient.

This invention provides a traditional Chinese medicine composition for the prevention and treatment of knee arthritis. The active ingredients, by weight, include: 15-25 parts of Salvia miltiorrhiza, 8-15 parts of Ligusticum chuanxiong, 12-20 parts of Angelica sinensis, 7-15 parts of Lycopus lucidus, 15-30 parts of Poria cocos, 8-15 parts of Placenta hominis, 18-30 parts of Clematis chinensis, 15-25 parts of Spatholobus suberectus, 25-40 parts of Paeonia lactiflora, 12-20 parts of Rehmannia glutinosa, and 8-15 parts of Glycyrrhiza uralensis. Using Salvia miltiorrhiza, Ligusticum chuanxiong, Angelica sinensis, Lycopus lucidus, Poria cocos, Placenta hominis, Clematis chinensis, Spatholobus suberectus, Paeonia lactiflora, Rehmannia glutinosa, and Glycyrrhiza uralensis as raw materials, this invention follows the principle of "principal, assistant, adjuvant, and guide" in traditional Chinese medicine. The combined use of these herbs can tonify the liver and kidneys, promote blood circulation and remove blood stasis, and has a good therapeutic effect on knee arthritis caused by liver and kidney deficiency and qi stagnation and blood stasis.

The invention discloses a pill for treating qi-blood deficiency and a preparation method thereof, and belongs to the technical field of Chinese patent medicine preparation. Comprising 80-90 parts of wall-broken ginseng rootlets, 140-160 parts of freeze-dried Chinese wolfberry fruits, 190-210 parts of fried Chinese yam powder, 110-130 parts of fermented Chinese date powder, 50-70 parts of donkey-hide gelatin beads, 80-100 parts of black sesame seed powder, 45-55 parts of maltitol, 15-25 parts of giant knotweed rhizomes, 10-14 parts of red peony roots and 0.5 part of a compound enzyme preparation. The medicine is small in packaging size, convenient to carry and low in cost; the traditional Chinese medicine composition has the advantages of scientific formula, wide application range, stable process and controllable quality, and embodies the traditional Chinese medicine theory advantages of simultaneous treatment of vital qi and pathogen and simultaneous regulation of qi and blood. Acute toxicity tests show that LD50 is larger than 20 g / kg, and the traditional Chinese medicine is free of liver and kidney dysfunction after being taken for a long time and suitable for long-term conditioning.

The application provides a method for analyzing the synergistic mechanism of hepatotoxicity and nephrotoxicity of non-steroidal anti-inflammatory drugs. The method comprises the following steps: preliminary toxicity prediction of NSAIDs and collection of toxicity target points, collection of liver and kidney disease target points, then cross and screening of the target points to obtain core target points and common core target points of NSAIDs induced liver and kidney diseases, and then constructing a protein interaction network of the common core target points; enrichment analysis of the common core target points to obtain the common action pathway of NSAIDs induced liver and kidney diseases; finally, further screening of the common core target points to obtain the key target points of NSAIDs induced liver and kidney diseases, and verification by using molecular docking technology. Compared with the traditional method, the advantages of the method are: first, the method does not depend on large-scale patient clinical data and a large number of animal or cell experiments, avoiding the ethical controversy in animal experiments and human experiments; second, the method can identify the potential cross-pathway and synergistic toxicity mechanism when a compound triggers multiple diseases, which is helpful for more comprehensive evaluation of the toxicity risk of NSAIDs.

The invention provides a traditional Chinese medicine for treating protrusion of lumbar intervertebral disc, and relates to the technical field of traditional Chinese medicines. Aiming at the core pathogenesis of qi stagnation and blood stasis, deficiency of liver and kidney and cold-dampness arthralgia of the lumbar intervertebral disc protrusion, a synergistic compatibility concept of promoting blood circulation to remove blood stasis, tonifying liver and kidney, dispelling cold-dampness and activating meridians to stop pain is adopted. The traditional Chinese medicine is prepared from 12 traditional Chinese medicines such as ligusticum wallichii, safflower, eucommia ulmoides and radix achyranthis bidentatae through an optimized process of crushing, extracting, concentrating and forming, and the dosage form comprises tablets, capsules or oral liquid. The core innovation lies in accurate matching of the formula, multi-target synergistic effect is achieved, and the problems that traditional Chinese medicine is slow in curative effect and poor in pertinence are solved. Clinical verifications show that the traditional Chinese medicine can relieve lumbar pain within 7 days and improve symptoms such as numbness of lower limbs and limited movement within 1-2 treatment courses, has the total effective rate of greater than or equal to 92%, is safe, has no obvious toxic or side effect, is suitable for patients with different types of lumbar disc herniation, and is convenient to take and high in cost performance.

The application discloses application of white ginseng mushroom in preparation of a medicine for treating hyperuricemia, and belongs to the technical field of deep processing of edible mushrooms. The white ginseng mushroom is vacuum freeze-dried, ground into powder, other traditional Chinese medicine ingredients are extracted, concentrated, and spray-dried into powder; the white ginseng mushroom powder is mixed with sodium carboxymethyl cellulose and guar gum solution to form a mushroom suspension colloid, the microcapsules are collected after being dropped into a calcium-containing aqueous solution; the microcapsules are immersed in a high polymer compound solution for treatment, finally mixed with a stabilizer paste, and then filled after being treated by a high-pressure homogenizer and sterilized. Compared with the prior art, the medicine has good stability in simulated gastric juice, can be quickly released in simulated intestinal juice, significantly improves the bioavailability and curative effect of the medicine, can effectively reduce the serum uric acid level, improve liver and kidney functions, and regulate the intestinal flora structure, and has a significant uric acid-lowering effect and multi-target synergistic effect.

The invention discloses a traditional Chinese medicine mixture with a liver and kidney tonifying effect and a preparation method thereof, and belongs to the field of pharmaceutical preparations. The traditional Chinese medicine mixture comprises the following components in parts by weight: 45-60 parts of polygonum multiflorum; 45-60 parts of rhizoma polygonati; 110 to 130 parts of fructus rosae laevigatae; 2.4 to 3.2 parts of Chinese angelica; 45-60 parts of rhizoma cibotii; 3.2 to 3.8 of semen cuscutae; 1.8-2.4 parts of dried orange peel; 3.5 parts of fructus psoraleae; the preparation method of the traditional Chinese medicine mixture comprises the following steps: decocting the components in water, filtering, concentrating filtrate until the density is 1.10-1.16 g / mL, adding ethanol until the alcohol content is 60%, standing for 24 hours, taking supernate, filtering, and recovering the filtrate under reduced pressure until no alcohol exists; adding water to 120 parts by weight, adding 2 parts by weight of talcum powder and 1 part by weight of sodium benzoate, uniformly stirring, and standing for 24-48 hours; taking supernatant liquid, adding 120-150 parts by weight of cane sugar, adding water to 300-350 parts by weight, uniformly stirring, boiling, standing and filtering to obtain filtrate, namely the product mixture. Eight medicines of the traditional Chinese medicine mixture are applied dialectically, and complement each other in tonifying liver and kidney, invigorating spleen and replenishing qi, arresting seminal emission and arresting enuresis.

The application belongs to the technical field of nanomedicine, tumor treatment and immunotherapy, and specifically provides a copper death selective induction nanoparticle targeting tumor mitochondria, which is prepared by the following preparation method: S1, TPY is specifically coupled with MHI through a condensation reaction to obtain MTPY; S2, MTPY is complexed with copper ions to obtain an MTPY-Cu complex; and S3, the MTPY-Cu complex is self-assembled with albumin to form an MTPY-Cu@Alb nanoparticle. The copper dose of the application is only 1 / 1000 of that of free Cu 2+ , and the equivalent immune regulation and killing effects can be achieved; the primary tumor and distant tumor foci can be inhibited, and lung metastasis can be reduced; and the application can induce immune memory and prevent recurrence; the application is combined with cisplatin to significantly enhance the therapeutic effect and reverse the induced immunosuppression; and the application has high biological safety, and has no obvious hepatorenal toxicity or hemolytic reaction.

The invention discloses a medicine formula for preventing cerebral infarction and promoting rehabilitation and a preparation method thereof, and belongs to the technical field of preparation of medicines for preventing cerebral infarction, the medicine formula comprises the following raw materials by weight: 10-15 parts of flatstem milkvetch seed, 10-15 parts of dodder, 10-15 parts of tortoise plastron, 10-12 parts of red peony root, 6-9 parts of safflower, and 15-30 parts of red sage root. According to the invention, the flatstem milkvetch seed, the semen cuscutae and the tortoise plastron are used for nourishing liver and kidney, replenishing essence and benefiting marrow, so that the traditional Chinese medicine theory that kidney dominates bone marrow generation and brain is marrow sea is met, and brain function decline is improved from the source; meanwhile, the radix salviae miltiorrhizae, the radix paeoniae rubra and the flos carthami have the effects of promoting blood circulation to remove blood stasis, activating meridians to stop pain, effectively improving brain microcirculation, inhibiting platelet aggregation and reducing blood viscosity, and supplement each other to achieve the effects of strengthening the body resistance to eliminate pathogenic factors and treating both symptoms and root causes, so that the traditional Chinese medicine composition can be used for preventing cerebral infarction of high-risk groups and is also suitable for functional recovery in the rehabilitation period after cerebral infarction.

The invention relates to the technical field of traditional Chinese medicines, and discloses an external traditional Chinese medicine formula for treating arthralgia with syndrome of cold-dampness obstruction, which comprises the following ingredients: 10g of cassia twig, 6g of dried ginger, 12g of lycopodium clavatum, 12g of herba lycopi, 10g of notopterygium root, 10g of radix angelicae pubescentis, 9g of loose knot, 9g of semen brassicae, 10g of rhizoma corydalis, 15g of caulis spatholobi and 10g of cortex acanthopanacis. According to the external traditional Chinese medicine formula for treating the cold-dampness arthralgia, through accurate compatibility of medicinal materials with effects of warming and dispelling cold and dampness, promoting blood circulation to remove meridian obstruction and strengthening tendons and bones, a synergistic treatment system of warming and dredging, eliminating dampness, dredging collaterals and protecting bones is formed, so that symptoms such as joint crymodynia, stiffness and the like can be quickly relieved, cold-dampness evil can be eliminated from the pathogenesis level, and qi and blood circulation of joints can be improved; by adopting a standard processing technology and an optimized preparation method, the transdermal efficiency is improved while the irritation of the medicinal materials is reduced, the medicine can directly reach the focus, the gastrointestinal tract side effect caused by oral administration is avoided, and the traditional Chinese medicine composition is particularly suitable for middle-aged and elderly people and cold-dampness blockage type arthralgia patients with poor liver and kidney functions and sensitive skin.

The invention provides an angelica sinensis and radix paeoniae alba blood-activating capsule, which belongs to the technical field of traditional Chinese medicine pharmacy and is prepared from the following traditional Chinese medicinal materials: angelica sinensis, radix paeoniae alba, astragalus membranaceus, deer-horn glue, fructus lycii, teasel root, cassia twig, peach kernel, centipede, dragon's blood, ground beetle, native copper (calcined), mustard seed and radix achyranthis bidentatae. Angelica sinensis and radix paeoniae alba nourish and activate blood as a core and cooperate with astragalus membranaceus to tonify qi, and qi circulation causes smooth blood circulation, so that the qi-blood running state of an organism can be effectively improved; the deer-horn glue, the fructus lycii and the radix dipsaci nourish and nourish the liver and the kidney, can enhance the self-repairing and nourishing capacity of the body and assist in strengthening muscles and bones; the cassia twig can warm and dredge meridians, and can dissipate blood stasis in the body, promote local blood circulation and relieve pain and swelling by matching with the peach kernel, the dragon's blood, the ground beetle and the native copper (calcined); the centipede is good in dredging collaterals, can go deep into meridians and collaterals and The mustard has the effects of warming lung, eliminating phlegm, benefiting qi and regulating qi activity; the radix achyranthis bidentatae removes blood stasis, stimulates the menstrual flow and leads the medicine to move downwards to directly reach the disease site, and the effects of promoting blood circulation to remove meridian obstruction, tonifying liver and kidney and strengthening tendons and bones are achieved through cooperation of multiple groups of medicinal materials.

This invention relates to the field of Traditional Chinese Medicine (TCM), specifically a kidney-tonifying and aphrodisiac food-derived composition and its preparation method. While the liver and kidneys differ in morphology, structure, and physiological function, TCM theory holds that they share a common origin, stemming from congenital reproductive essence and nourished by kidney essence. Therefore, the abundance or deficiency of yin fluid in both organs is characterized by mutual abundance and deficiency; abundant liver yin is stored in kidney water, while abundant kidney yin nourishes liver wood. The formula includes: mulberry, wolfberry, yam, leek seed, black sesame, and black bean. The synergistic effects of the combination include: tonifying the kidneys and strengthening the foundation, balancing yin and yang, nourishing yin and blood, replenishing kidney yin deficiency, warming kidney yang, consolidating essence and qi, balancing yin and yang, strengthening the spleen and stomach, promoting diuresis, replenishing qi and blood, anti-aging, improving indigestion, lubricating the intestines and promoting bowel movements, and detoxification. This combination focuses on "tonifying the kidneys" while also nourishing yin, warming yang, strengthening the spleen, moistening the intestines, and anti-aging. It is especially suitable for people with kidney deficiency, weak constitution, sub-health, and middle-aged and elderly people.

The invention provides a traditional Chinese medicine composition for nourishing liver and kidney and benefiting essence and blood as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1.5 to 2.5 parts of oyster peptide, 1.5 to 2.5 parts of sea cucumber peptide, 25 to 35 parts of herba cistanche, 15 to 25 parts of rhizoma polygonati, 10 to 20 parts of fructus lycii, 8 to 12 parts of cortex eucommiae, 8 to 12 parts of fructus rubi, 10 to 20 parts of radix astragali seu hedysari, 20 to 30 parts of herba epimedii, 4 to 6 parts of radix panacis quinquefolii, 1.5 to 2.5 parts of penis et testis cervi, 8 to 12 parts of flos lonicerae, 5 to 8 parts of silkworm chrysalis, 15 to 20 parts of fructus mori, 4 to 6 parts of herba taraxaci, 5 to 8 parts of eurycoma longifolia and 1.5 to 2.5 parts of carpinacol. The traditional Chinese medicine composition disclosed by the invention is reasonable in compatibility, has the effects of tonifying kidney, strengthening essence and nourishing liver, and can be used for treating sexual hypofunction syndromes such as insufficiency of kidney yang, impotence, spermatorrhea and premature ejaculation. The whole prescription is scientific in compatibility, all medicines are mutually coordinated, and both symptoms and root causes are treated.

This invention discloses a fermented traditional Chinese medicine for treating hyperlipidemia, its preparation method, and its application, relating to the field of traditional Chinese medicine. This fermented traditional Chinese medicine is prepared using Bacillus sp. JQ.Y-1, which was deposited on June 24, 2021, at the China Center for Type Culture Collection (CCTCC), Wuhan University, Wuhan, China, with accession number CCTCC NO: M2021761. The fermented traditional Chinese medicine provided by this invention offers a new alternative drug for the treatment of hyperlipidemia of the dampness-obstruction type in the middle jiao (middle burner). It has a significant lipid-lowering effect, is safe and reliable, can regulate intestinal flora, protect the liver and kidneys, and has no side effects.

This invention discloses a water-soluble melanin CEST contrast agent, its preparation method, and its application, relating to the field of magnetic resonance imaging contrast agent technology. This contrast agent, its preparation method, and its application aim to solve the technical problem that existing contrast agents containing paramagnetic metals can damage liver and kidney function. This water-soluble melanin CEST contrast agent comprises the following components by weight: 2-3 parts ammonia, 40 parts ethanol, 100 parts deionized water, and 0.5 parts reaction substrate. The chemical shift corresponding to this contrast agent preparation method is 4.0 ppm, exhibiting good adaptability to acidic environments and suitability for use in the tumor microenvironment. It is polymerized using dopamine hydrochloride or 3,4-dihydroxyphenylalanine, with inexpensive, simple, and readily available raw materials, simple synthesis, and easy large-scale preparation. It achieves tumor imaging without the need for paramagnetic metal ions, avoiding the damage to liver and kidney function caused by heavy metal ions.

This invention proposes a traditional Chinese medicine preparation and its preparation method for treating olfactory dysfunction in Parkinson's disease of the liver and kidney yin deficiency type. Belonging to the field of traditional Chinese medicine preparations, it is made from the following raw materials: 10-15g of Rehmannia glutinosa (processed), 20-30g of Paeonia lactiflora, 10-15g of Spatholobus suberectus, 12-15g of Eclipta prostrata, 10-15g of Ligustrum lucidum, 8-10g of Centipeda minima, 10-15g of Acorus tatarinowii, and 10-15g of Angelica dahurica. The entire formula works synergistically to nourish the liver and kidneys, invigorate blood circulation, and clear the nasal passages, exhibiting good clinical therapeutic effects. This invention assesses the olfactory function of patients with olfactory dysfunction in Parkinson's disease of the liver and kidney yin deficiency type using the T&T olfactory test and other methods, and applies a traditional Chinese medicine nasal spray treatment, systematically exploring the therapeutic efficacy of this external application of traditional Chinese medicine for the aforementioned symptoms. This invention can provide clinical data support for the standardized diagnosis and treatment of olfactory dysfunction in Parkinson's disease and has significant clinical application value for improving patients' quality of life and optimizing the prognostic assessment system.

The invention discloses a targeting peptide for blocking combination of IL-17A and IL-17RA / RC and application thereof, the targeting peptide is selected from AZS-1, AZS-2, AZS-3, AZS-4 and AZS-5 or a combination of any one of AZS-1, AZS-2, AZS-3, AZS-4 and AZS-5 and IBP, the amino acid sequence of AZS-1 is as shown in SEQ ID NO: 1, the amino acid sequence of AZS-2 is as shown in SEQ ID NO: 2, the amino acid sequence of AZS-3 is as shown in SEQ ID NO: 3, the amino acid sequence of AZS-4 is as shown in SEQ ID NO: 4, and the amino acid sequence of AZS-5 is as shown in SEQ ID NO: 5. The amino acid sequence of the AZS-5 is as shown in SEQ ID NO: 5, and the amino acid sequence of the IBP is as shown in SEQ ID NO: 6. The targeting peptide provided by the invention has good tolerance, can generate effective interaction with the surface of a target protein, can realize specific binding with IL-17A, has relatively high blocking ability, can effectively improve symptoms of liver and kidney cell injury, cell edema and skin injury caused by psoriasis after being applied to a psoriasis mouse model, and has a good application prospect. The compound has a good application prospect in treatment and / or adjuvant therapy of IL-17A-mediated inflammatory diseases.

The invention relates to the technical field of pharmaceutical preparations, in particular to a traditional Chinese medicine composition for treating knee osteoarthritis, a preparation as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 10 to 15 parts of herba epimedii, 10 to 15 parts of fructus corni, 15 to 25 parts of rhizoma dioscoreae nipponicae, 15 to 30 parts of rhizoma smilacis glabrae, 10 to 15 parts of radix gentianae macrophyllae, 3 to 6 parts of ground beeltle, 10 to 15 parts of spina gleditsiae, 10 to 15 parts of radix achyranthis bidentatae, 10 to 15 parts of cortex eucommiae, 3 to 6 parts of radix notoginseng, 10 to 15 parts of rhizoma drynariae, 10 to 15 parts of radix paeoniae alba, 15 to 30 parts of semen coicis and 3 to 6 parts of liquorice root. The traditional Chinese medicine compound provided by the invention integrates tonifying, blood activating, dampness eliminating and collateral dredging medicines, and avoids the limitation of pure tonifying or evil eliminating, so that the traditional Chinese medicine compound is more in line with the characteristics of KOA deficiency in root and excess in superficies. The traditional Chinese medicine composition is especially suitable for patients with complex knee osteoarthritis with symptoms such as deficiency of liver and kidney, rheumatic arthralgia and stagnation of blood stasis. In addition, through multi-target treatment, the formula gives consideration to both symptoms and root causes, not only aims at local symptoms of KOA, but also adjusts the overall function.

This invention discloses a traditional Chinese medicine composition with calming and sleep-aiding effects and its preparation method, relating to the field of pharmaceutical technology. The traditional Chinese medicine composition with calming and sleep-aiding effects comprises the following raw materials in parts by weight: 15-25 parts of vetiver volatile oil, 15-25 parts of valerian volatile oil, 8-12 parts of sandalwood volatile oil, 8-12 parts of cyperus rotundus volatile oil, 8-12 parts of albizia julibrissin bark volatile oil, 5-8 parts of orange blossom volatile oil, 8-12 parts of polygala tenuifolia volatile oil, 8-12 parts of schisandra chinensis volatile oil, 5-8 parts of jasmine volatile oil, and 500-520 parts of fractionated coconut oil. This invention also provides a method for preparing the traditional Chinese medicine composition with calming and sleep-aiding effects, effectively solving the problems of existing sleep aid products that easily cause liver and kidney metabolic burden, gastrointestinal irritation, uncontrollable dosage of active ingredients, and ingestion of ineffective ingredients.

This invention discloses a kidney-tonifying and blood-activating traditional Chinese medicine composition and its application in improving postoperative visual function, belonging to the field of pharmaceutical technology. The kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is made from 10 parts of Cuscuta chinensis, 15 parts of Broussonetia papyrifera fruit, 18 parts of Lycium barbarum, 15 parts of Leonurus japonicus, 20 parts of Leonurus japonicus, 10 parts of Ligusticum chuanxiong, 9 parts of Prunus persica kernel, 6 parts of Carthamus tinctorius, 15 parts of Poria cocos, 18 parts of Albizia julibrissin bark, 12 parts of Astragalus membranaceus, and 12 parts of Pueraria lobata root. It can be standardized and adjusted according to clinical complications. This invention focuses on the critical point of "kidney deficiency and blood stasis" one month after posterior scleral reinforcement surgery, using the principles of tonifying the liver and kidneys and activating blood circulation to improve ocular microcirculation, enhance and stabilize vision, thereby protecting visual function, and conforming to the treatment principle of "treating the root cause when the condition is mild."

The invention discloses a traditional Chinese medicine for treating leucoderma and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. Comprising medicine for oral administration, astragalus membranaceus, codonopsis pilosula, bighead atractylodes rhizome, rhizoma smilacis glabrae, Chinese yam, fructus psoraleae, angelica sinensis, buffalo horn shreds, dogwood, salvia miltiorrhiza, red paeony root, safflower carthamus, ligusticum wallichii, peach kernel, polygonum multiflorum, eclipta alba, white mulberry root-bark, divaricate saposhnikovia root, radix bupleuri, scutellaria baicalensis, curcuma aromatica, fingered citron, rhizoma cyperi, felwort, parched white peony root, tribulus terrestris, gardenia, radix angelicae and rhizoma typhonii. The external immersion liquid comprises fructus psoraleae, radix angelicae, cortex dictamni, radix polygoni multiflori, borax, rhizoma typhonii, semen cuscutae, flos carthami and white spirit. Through oral administration for regulating qi and blood, tonifying liver and kidney, dredging meridians and collaterals and consolidating root, external application for dredging local parts and promoting pigment, internal and external synergism and simultaneous treatment of both symptoms and root causes, the traditional Chinese medicine is especially suitable for middle-aged and elderly patients with qi and blood deficiency, deficiency of liver and kidney and qi stagnation and blood stasis type leucoderma.

The invention relates to the technical field of knee joint disease prevention and treatment, in particular to a knee joint remote functional therapy, which comprises a treatment end and a patient execution end, and is characterized in that the treatment end is used for sending an auxiliary treatment video, an auxiliary treatment audio and a voice instruction to the execution end through a network; the auxiliary treatment terminal receives the auxiliary treatment video, the auxiliary treatment audio and the voice instruction sent by the treatment terminal and is used for guiding and activating the knee joint self-healing function of the patient, cooperatively dredging knee joint meridians and collaterals and eliminating inflammation. The knee joint remote functional therapy method has the advantages that no medicine or injection or operation is needed, and damage of chemical medicine to liver and kidney functions and damage of operation to human tissue structures are avoided; space-time limitation is broken through in a remote mode, patients do not need to go back and forth to medical institutions, each treatment only needs 10 minutes, and operation does not need professional skills. The treatment end can send energy videos to large-scale patients at the same time, and the problem that traditional one-to-one treatment is low in efficiency is solved.

This invention discloses a traditional Chinese medicine composition for treating degenerative bone diseases, its preparation method, and its application. It is made from the following raw materials in parts by weight: 30-50 parts Rehmannia glutinosa (processed), 15-30 parts deer antler glue, 20-80 parts Cistanche deserticola, 15-50 parts Morinda officinalis, 15-50 parts tortoise shell glue, 30-80 parts Lycium barbarum, 10-50 parts Curculigo orchioides, 15-50 parts Eucommia ulmoides, 20-80 parts Cuscuta chinensis, and 30-50 parts Dioscorea opposita. 0 parts, Drynaria fortunei 15-50 parts, Achyranthes bidentata 10-50 parts, Taxillus chinensis 20-50 parts, Broussonetia papyrifera 15-30 parts, Clematis chinensis 15-50 parts, Acanthopanax senticosus 15-50 parts; Through the formulation strategy of "regulating the liver and kidneys, nourishing essence and blood, and combining tonification and purging", combined with a specific extraction process, it systematically regulates the balance of bone metabolism, achieves dual prevention and treatment of osteoporosis and bone hyperplasia, and treats both the symptoms and the root cause, and has high safety for long-term use.

This invention discloses a traditional Chinese medicine composition and its preparation method for treating liver, kidney, and cardiovascular diseases, relating to the field of traditional Chinese medicine preparations. It is made from the following raw materials in parts by weight: 10-30 parts of Gastrodia elata, 15-40 parts of Salvia miltiorrhiza, 10-25 parts of Panax quinquefolius, 10-30 parts of Panax notoginseng, 5-20 parts of Chrysanthemum morifolium, and 10-15 parts of Gecko. This traditional Chinese medicine composition and its preparation method for treating liver, kidney, and cardiovascular diseases features synergistic innovation in formulation, is suitable for specific populations, and achieves the therapeutic effects of clearing liver heat, promoting blood circulation, nourishing qi and yin, and tonifying the liver and kidneys. The process preserves the active ingredients, is suitable for absorption by middle-aged and elderly individuals, and maximizes the retention of heat-sensitive active ingredients such as gastrodin, total saponins of Panax notoginseng, tanshinone IIA, and total flavonoids of Chrysanthemum morifolium. The dosage form is flexible and adaptable, with a wide range of applications. Both the ultrafine powder and oral liquid preparations avoid irritating components. The application is clearly targeted, with significant differentiated advantages, especially suitable for middle-aged and elderly men around 70 years old and individuals with hyperglycemia and dizziness.

The application discloses application of Dingxuan Granules in preparation of medicines for treating early kidney damage caused by hypertension of the type of yin deficiency and yang hyperactivity, and the Dingxuan Granules are prepared from radix rehmanniae, lycium barbarum, gastrodia, uncaria, wine salvia miltiorrhiza, alisma, motherwort and achyranthes bidentata. The Dingxuan Granules have the effects of tonifying liver and kidney, calming liver wind and promoting water and descending qi, and are suitable for people with early kidney damage caused by hypertension.