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Oral liquid used for resisting aging, preparation method thereof, and quality controlling method thereof

An oral liquid and anti-aging technology, applied in the field of medicine, can solve problems such as chronic fatigue syndrome and other diseases that have not been seen

Inactive Publication Date: 2012-04-04
THE PHARMA FACTORY OF CHENGDU HOIST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching domestic and foreign literature and patents, the inventor has found no Chinese patent medicine preparations that can treat menopausal syndrome, neurasthenia, chronic fatigue syndrome and other diseases

Method used

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  • Oral liquid used for resisting aging, preparation method thereof, and quality controlling method thereof
  • Oral liquid used for resisting aging, preparation method thereof, and quality controlling method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 oral liquid preparation example of the present invention

[0040] Add 1000g of Radix Polygoni Multiflori, 220g of Salvia miltiorrhiza, and 300g of medlar to decoct three times, combine the decoction, filter, concentrate the filtrate to syrup (relative density at 60°C is 1.2), let it cool, add ethanol to make the alcohol content reach 70 %, place, filter, add ethanol to the filtrate to make the alcohol content reach 80%, place, filter, adjust the pH value of the filtrate to 8.0 with 10% sodium hydroxide solution, place, filter, and wash the filtrate with 10% hydrochloric acid Adjust the pH value of the liquid to 7.0, recover the ethanol, and reserve the liquid medicine;

[0041]Add 300g of Epimedium and 440g of Polygonatum (manufactured) to decoct twice, combine the decoction, filter, let stand, concentrate the filtrate to a relative density of 1.2 (50°C), let it cool, add ethanol until the alcohol content reaches 65%, stand still, filter, add ethanol to th...

Embodiment 2

[0044] Embodiment 2 oral liquid mouse oral tolerance assay of the present invention

[0045] 1. Test material

[0046] (1) Test animals

[0047] 10 healthy SD mice, weighing 17g-22g, half male and half male, provided by the Experimental Animal Center of Sichuan Antibiotic Industry Research Institute, animal qualification certificate number: Chuan Shi Dong Guan No. 32.

[0048] (2) Experimental drug

[0049] Oral liquid prepared according to Example 1, brown liquid, every 10ml, crude drug content is 27g / .

[0050] 2. Test method

[0051] (1) Administration route and dosage

[0052] With above-mentioned 10 mice after fasting for 12 hours, give oral liquid 240.975g crude drug / kg body weight of the present invention once by gavage (due to the limitation of stomach capacity by gavage of mice, so the medicinal liquid used in this experiment is prepared in Example 1 3.57 times concentrated solution of oral liquid).

[0053] (2) Detection indicators: observe the behavioral activ...

Embodiment 3

[0059] Embodiment 3 The clinical trial of oral liquid of the present invention treating climacteric syndrome

[0060] 1. Clinical trial samples:

[0061] 88 patients over 40 years old or after surgical removal of bilateral ovaries, menstrual disorders or menopausal patients with obvious menopausal symptoms. The patients were randomly divided into two groups: 46 cases in the treatment group, aged 46-52 years, with an average age of 59; 42 cases in the control group, aged 45-50 years, with an average age of 47.5 years. There was no significant difference in the general condition of the two groups of patients. All patients were tested for blood, liver and kidney function before treatment.

[0062] 2. Treatment

[0063] The treatment group took the oral liquid of the present invention prepared according to Example 1, 10 mL each time, 1 time / day; the control group took oryzanol tablets, 20 mg each time, 3 times / day. Both groups took 90 days as a course of treatment, and the cur...

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Abstract

The invention relates to an oral liquid used for resisting aging. The oral liquid is prepared from traditional Chinese medicines of prepared fleeceflower root, epimedium, prepared Siberian solomonseal rhizome, medlar, Mongolian milkvetch root, and salvia miltiorrhiza of different parts by weight. The invention also relates to a preparation method and a quality controlling method of the oral liquid. The oral liquid provided by the invention provides functions of vital energy benefiting, blood nourishing, and liver and kidney nourishing. With the oral liquid, climacteric syndrome, neurasthenia, and chronic fatigue syndrome can be treated. The oral liquid can also be used for treating phenomena of senility and physical weakness, lethargy, insomnia, amnesia, dim eyesight, deafness, and early-canities caused by insufficiency of vital energy and blood and deficiency of liver and kidney. As a result of acute toxicity tests, no obvious adverse reaction is caused by the oral liquid. Therefore, the preparation is a safe and effective Chinese patent medicine which is suitable to be clinically applied and popularized.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an anti-aging oral liquid, a preparation method and a quality control method thereof. Background technique [0002] The incidence of diseases such as climacteric syndrome, neurasthenia, and Chronic Fatigue Syndrome (Chronic Fatigue Syndrome, CFS) has increased significantly due to the accelerated pace of people's life and increased work pressure. CFS is caused by long-term high physical and mental stress or excessive mental burden, causing memory loss, inattention, sleep disorders, mental drowsiness, weakness of limbs and other systemic symptoms. The U.S. Centers for Disease Control predicts that CFS will become a major problem affecting human health in the 21st century. So far, there is no specific drug for treatment. [0003] Chinese patent medicine preparations can adjust the body's peroxidation balance as a whole, delay aging, regulate and improve the body's immune function, protect ...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K9/00G01N30/36G01N30/90A61P39/06
Inventor 杨华蓉万方林大胜张劲松高星王浪波
Owner THE PHARMA FACTORY OF CHENGDU HOIST
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