30 results about "Pyridine sulfonamide" patented technology

The present invention relates to a synergistic herbicidal composition comprising N- [ [(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl] -2- [2-fluoro- 1 -(methoxymethylcarbony loxy)propyl] -3 -pyridine sulfonamide or N-[[(4,6-dimethoxy-2-pyrimidinyl)amino] carbonyl]-2-[2-fluoro-l-(hydroxy)propyl]-3-pyridine sulfonamide and other herbicidal active materials as active ingredient. The herbicidal composition of the present invention can increase the herbicidal efficacy against major weeds, and can reduce the use amount of active ingredients per unit area, due to the synergistic effect by mixing two herbicidal active ingredient having different physiological functions or different herbicidal activities.

The invention relates to the technical field of biological medicines, and particularly relates to a pyridine sulfonamide phosphate compound as well as a preparation method and application thereof. Thestructure of the pyridine sulfonamide phosphate compound is shown as a formula I shown in the specification. The pyridine sulfonamide phosphate compound has the beneficial effects that the pyridine sulfonamide phosphate compound has the characteristics of high solubility, high stability, convenience in preparation of preparations and the like, is easy to industrially amplify and is used for medical application.

The invention relates to heterocyclic compounds of the formula (I)in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

Not so many reports on the practical use of herbicidal sulfonylurea compounds have been made since they easily decompose in water or a process for production of their suspensions is complicated. Therefore, it is desired to prepare a water-based herbicidal suspension in which a herbicidal sulfonylurea compound will not decompose in water and excellent suspensibility of which is maintained, without complicated process. A water-based herbicidal suspension comprising (1) a herbicidal sulfonylurea compound (excluding 1-[3-[(4,6-dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl]-2-pyridyl]-2-fluoropropyl methoxyacetate and N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(2-fluoro-1-hydroxypropyl)-3-pyridinesulfonamide) or its salt, (2) an inorganic salt, (3) at least one sulfonate selected from the group consisting of an aryl sulfonate, an alkylaryl sulfonate and their formaldehyde condensates and (4) water.

The invention relates to a preparation method of vonopraza. The preparation method of the vonoprazan, provided by the invention, comprises the following steps of taking 2-bromo-2'-fluoroacetophenone shown as a formula 3 as a starting raw material; reacting with 3-oxoethyl propionate to generate 4-(2-fluorophenyl)-2-formacyl-4-oxoethyl butyrate shown as a formula 39; then carrying out cyclization reaction on 4-(2-fluorophenyl)-2-formacyl-4-oxoethyl butyrate and pyridine-3-sulfonamide to generate 5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-ethyl formate shown as a formula 40; then carrying out reduction and substation reaction to generate 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methyl methylamine shown as a formula 1, i.e., the vonoprazan. The preparationmethod of the vonoprazan, provided by the invention, has the characteristics of few synthesis steps and high yield.

The present invention relates to a novel class of pyridine-sulfonamide compounds and to compositions comprising the same. The compounds and compositions are useful as medicaments in the treatment of diseases responsive to inhibition of IL-1beta, such as non-alcoholic steatohepatitis (NASH) and idiopathic pulmonary fibrosis (IPF).

The present invention provides compounds of Formula (I), as defined in the specification, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention.

A herbicidal suspension concentrate composition is provided, the composition comprising at least one pyridine sulfonamide active ingredient and a polyether-polysiloxane. The pyridine sulfonamide compound preferably has the general formula (I):

A triazolopyrimidine sulfonamide compound and a synthesis method and use thereof; the present invention relates to a penoxsulam analogue and a synthesis method and use thereof. An object of the present invention is to solve the existing problems that the synthesis of penoxsulam is greatly difficult and has high costs. A triazolopyrimidine sulfonamide compound of structural formula (I) or (II); method 1: (1) preparing a 2-methyl-3-chlorobenzenesulfonyl chloride; (2) preparing a finished product, that is to say obtaining 3-chloro-2-methyl-N-(5,8-dimethoxyl-[1,2,4]triazolo[1,5-c]pyrimidine-2-yl)benzene sulfonamide. Method 2: (1) preparing 2-mercapto-3-trifluoromethyl pyridine; (2) preparing 3-trifluoromethyl pyridine-2-sulfonyl chloride; (3) preparing a finished product, that is to say obtaining 3-trifluoromethyl-N-(5,8-dimethoxyl-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)pyridine sulfonamide. The triazolopyrimidine sulfonamide compound is used as a rice field herbicide.

The invention discloses a method for preparing high-purity torasemide and a crystal form I thereof. The method comprises the following steps of: reacting 4-chloro-3-pyridine sulfonamide and m-toluidine serving as raw materials to obtain 3-sulfamoyl-4-(3-methyl phenyl) aminopyridine, refining, and reacting with 1,1'-carbonyldimidazole and isopropamide, directly introducing isopropyl carbamyl, thus obtaining the high-purity torasemide, wherein the purity (high performance liquid chromatography (HPLC)) of the torasemide is more than 99.5 percent. The prepared torasemide has proper granularity, seed crystal is not required for crystal transformation, the torasemide can be directly transformed into the variant crystal form I, and a chemically pure torasemide variant I is obtained. The preparation method is strong in process controllability, easy and convenient to operate and high in reproducibility, and facilitates industrialized production.

The object is to prepare an aqueous suspension-type herbicide composition which can avoid the decomposition of a herbicidal sulfonylurea compound in water and can also retain a stable suspension state, without the need of using any complicated step. An aqueous suspension-type herbicide composition comprising: (1) at least one herbicidal sulfonylurea compound selected from the group consisting of 1-[3-[(4,6-dimethoxypyrimidin- 2-ylcarbamoyl)sulfamoyl]-2-pyridyl]-2-fluoropropyl methoxyacetate, N-[(4,6-dimethoxypyrimidin-2- yl)aminocarbonyl]-2-(2-fluoro-1-hydroxypropyl)-3- pyridinesulfonamide and salts thereof; (2) an inorganic salt; (3) at least one sulfonate salt selected from the group consisting of an arylsulfonate, an alkylarylsulfonate and formalin condensates thereof; and (4) water.

The invention discloses a preparation method of 3-ethylsulfonyl-2-pyridinesulfonamide and an intermediate thereof and provides a preparation method of 3-ethylsulfonyl-2-pyridinethiol. The preparation method of 3-ethylsulfonyl-2-pyridinethiol comprises the following step of carrying out nucleophilic substitution on 2,3-diethylsulfonylpyridine and a thiolation reagent in a solvent to obtain 3-ethylsulfonyl-2-pyridinethiol, wherein the thiolation reagent is a mixture of sodium sulfide and sulfur or sodium hydrosulfide. According to the preparation method disclosed by the invention, cheap 2,3-dichloropyridine is used as a raw material, the reaction step is simple, the total yield is high, and the production cost is greatly reduced; and the preparation method is suitable for industrial production.