30 results about "Pyridine sulfonamide" patented technology

The present invention relates to a synergistic herbicidal composition comprising N- [ [(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl] -2- [2-fluoro- 1 -(methoxymethylcarbony loxy)propyl] -3 -pyridine sulfonamide or N-[[(4,6-dimethoxy-2-pyrimidinyl)amino] carbonyl]-2-[2-fluoro-l-(hydroxy)propyl]-3-pyridine sulfonamide and other herbicidal active materials as active ingredient. The herbicidal composition of the present invention can increase the herbicidal efficacy against major weeds, and can reduce the use amount of active ingredients per unit area, due to the synergistic effect by mixing two herbicidal active ingredient having different physiological functions or different herbicidal activities.

Invented is a method of inhibiting the activity/function of PI3 kinases using pyridosulfonamide derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of pyridosulfonamide derivatives.

The invention discloses a method for preparing high-purity torasemide and a crystal form I thereof. The method comprises the following steps of: reacting 4-chloro-3-pyridine sulfonamide and m-toluidine serving as raw materials to obtain 3-sulfamoyl-4-(3-methyl phenyl) aminopyridine, refining, and reacting with 1,1'-carbonyldimidazole and isopropamide, directly introducing isopropyl carbamyl, thus obtaining the high-purity torasemide, wherein the purity (high performance liquid chromatography (HPLC)) of the torasemide is more than 99.5 percent. The prepared torasemide has proper granularity, seed crystal is not required for crystal transformation, the torasemide can be directly transformed into the variant crystal form I, and a chemically pure torasemide variant I is obtained. The preparation method is strong in process controllability, easy and convenient to operate and high in reproducibility, and facilitates industrialized production.

The invention provides a triazolopyrimidine sulfonamide compound and synthetic methods and application thereof, relating to a penoxsulam analog and a synthetic method and application thereof. The objective of the invention is to overcome the problems of great synthesis difficulty and high cost of conventional penoxsulam. The triazolopyrimidine sulfonamide compound has a structural formula described in the specification. The method 1 comprises the following steps: 1, preparing 2-methyl-3-chlorobenzenesulfonyl chloride; and 2 preparing a finished product so as to obtain 3-chloro-2-methyl-N-(5,8-dimethoxy-[1,2,4] triazolo[1,5-c]pyrimidine-2-yl) benzsulfamide. The method 2 comprises the following steps: 1, preparing 2-mercapto-3-trifluoromethylpyridine; and 2, preparing 3-trifluoromethylpyridine-2-sulfonyl chloride; and 3, preparing a finished product so as to obtain 3-trifluoro-methyl-N-(5,8-dimethoxy-[1,2,4] triazolo[1,5-c]pyrimidine-2-yl) pyridine sulfamide. The triazolopyrimidine sulfonamide compound is used as a herbicide in a rice field.

The object is to prepare an aqueous suspension-type herbicide composition which can avoid the decomposition of a herbicidal sulfonylurea compound in water and can also retain a stable suspension state, without the need of using any complicated step. An aqueous suspension-type herbicide composition comprising: (1) at least one herbicidal sulfonylurea compound selected from the group consisting of 1-[3-[(4,6-dimethoxypyrimidin- 2-ylcarbamoyl)sulfamoyl]-2-pyridyl]-2-fluoropropyl methoxyacetate, N-[(4,6-dimethoxypyrimidin-2- yl)aminocarbonyl]-2-(2-fluoro-1-hydroxypropyl)-3- pyridinesulfonamide and salts thereof; (2) an inorganic salt; (3) at least one sulfonate salt selected from the group consisting of an arylsulfonate, an alkylarylsulfonate and formalin condensates thereof; and (4) water.

A herbicidal suspension concentrate composition is provided, the composition comprising at least one pyridine sulfonamide active ingredient and a polyether-polysiloxane. The pyridine sulfonamide compound preferably has the general formula (I):

The invention relates to a pharmaceutical intermediate, in particular to a method for preparing a key intermediate 5-alkyl-2-pyridine sulfonamide of pyridine sulfonamide miazines pharmaceutical active species. The method has three steps as follows: firstly, 2-alkyl pyridine chloride reacts with sodium sulfite to produce alkyl pyridine-2-sodium sulfonate; secondly, alkyl pyridine-2-sulfonic acid chloride is produced under the effect of chlorinating reagents and finally, pyridine-2-sulfonic acid amide is produced through amination. The method of the invention is simple in technique, mild in reaction conditions, safe and convenient in operation, easy in acquiring the raw materials, high in product yield and purity, few in three wastes and suitable for industrial production.

The invention relates to a novel torasemide impurity and a preparation method thereof. The invention relates to a novel torasemide impurity, namely TL-Imp07: 4-m-toluene amino-N-[(4-m-toluene aminopyridine-3-yl) sulfonyl] pyridine-3-sulfonamide. The preparation method of the TL-Imp07 comprises the steps of carrying out condensation and ammoniation reactions on 4-chloro-3-pyridine sulfonamide. The impurity is novel in structure, is reported for the first time and has great significance on quality control of torasemide crude drugs and preparations. Meanwhile, the preparation method has the advantages of being simple, convenient to operate, high in product purity and the like and can be applied to research of impurity reference substances of torasemide.

The invention relates to a synergistic weeding composition for a paddy field. The effective components of the synergistic weeding composition comprise (R)-2-[4(4-cyano-2-fluorophenyloxy)phenyloxy]-butyl propionate and one selected from a group consisting of 3-chloro-2-methyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonic amide and 3-trichloromethyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)pyridinesulfonamide, wherein a weight ratio of the effective components is (1-20): (1-10). The synergistic weeding composition exerts synergistic effect on grassy weeds, improves weeding effect and is safe to paddy rice.

The invention discloses a preparation method of 3-ethylsulfonyl-2-pyridinesulfonamide and an intermediate thereof and provides a preparation method of 3-ethylsulfonyl-2-pyridinethiol. The preparation method of 3-ethylsulfonyl-2-pyridinethiol comprises the following step of carrying out nucleophilic substitution on 2,3-diethylsulfonylpyridine and a thiolation reagent in a solvent to obtain 3-ethylsulfonyl-2-pyridinethiol, wherein the thiolation reagent is a mixture of sodium sulfide and sulfur or sodium hydrosulfide. According to the preparation method disclosed by the invention, cheap 2,3-dichloropyridine is used as a raw material, the reaction step is simple, the total yield is high, and the production cost is greatly reduced; and the preparation method is suitable for industrial production.

The invention relates to a weeding composition for a paddy field. The effective component of the weeding composition comprises a compound (A) and a compound (B), wherein (A) is 2-chloro-2,6'-diethyl-N-(2-propyloxyethyl)acetanilide, and (B) is one selected from a group consisting of 3-chloro-2-metyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzsulfamide and 3-trifluoromethyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)pyridinesulfonamide. The weeding composition has synergistic effect and a broadened weeding spectrum and is applicable to prevention and treatment of weeds in the paddy field.

The invention relates to a synergistic weeding composition for a paddy field. The synergistic weeding composition comprises a compound (A) and a compound (B) in a weight ratio of (10-80): 1, wherein (A) is N-(butoxymethyl)-alpha-chloro-alpha',6'-diethylacetanilide, and (B) is one selected from a group consisting of 3-chloro-2-metyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzsulfamide and 3-trifluoromethyl-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)pyridinesulfonamide. The synergistic weeding composition provided by the invention exerts synergistic effect on grassy weeds, improves weeding effect and is safe to paddy rice. The weeding composition has synergistic effect and a broadened weeding spectrum and is applicable to prevention and treatment of weeds in the paddy field.

The invention relates to application of a pyridine sulfonamide phosphate compound or a pharmaceutical composition containing the pyridine sulfonamide phosphate compound in preparation of an anti-encephaledema drug. The pyridine sulfonamide phosphate compound can quickly reduce intracranial pressure, is used for treating encephaledema caused by various reasons and preventing cerebral hernia, is high in safety, has no serious adverse effects such as liver and kidney injury and the like, is expected to become a novel clinical anti-encephaledema medicine, and has a very wide clinical application prospect.