A traditional Chinese medicine composition for treating recurrent oral ulcer, a traditional Chinese medicine preparation and a preparation method thereof

Abstract

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating recurrent oral ulcer, a traditional Chinese medicine preparation and a preparation method. The traditional Chinese medicine composition for treating recurrent oral ulcer has the effects of supporting healthy qi, promoting tissue regeneration and clearing heat and detoxifying, is scientific and reasonable in prescription, and simple in preparation process. When used as a medicine for treating recurrent oral ulcer, the traditional Chinese medicine composition has the excellent characteristics of remarkable curative effect, short treatment course, low recurrence after recovery, small toxic and side effects, and can effectively avoid the adverse reactions caused by western medicines. The traditional Chinese medicine composition for treating recurrent oral ulcer is accurate and complete in syndrome differentiation, has the synergistic effect of components, treats symptoms and root causes at the same time, has good treatment effect and low recurrence rate, and is helpful to popularization and application in production practice.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating recurrent oral ulcer, a traditional Chinese medicine preparation and a preparation method. BACKGROUND

[0002] Oral ulcer is a kind of oral mucosa disease with periodic recurrence, which can be self-healed and can occur in any part of oral mucosa. It is mostly seen in the mucosa of lips, cheeks, soft palate or gums of oral cavity, and a single or multiple ulcers of different sizes in circular or oval shape occur, with obvious local ulceration and burning pain, and the characteristics of periodicity, recurrence and self-limitation. According to traditional Chinese medicine, the disease is mostly caused by heat accumulation in the spleen and stomach and upward flaming of deficiency fire, and should be treated by clearing the spleen and stomach, nourishing yin and clearing heat. The treatment according to traditional Chinese medicine is mainly divided into the following types: spleen and stomach heat accumulation type, heart fire upward flaming type, liver stagnation and heat accumulation type, yin deficiency and fire exuberance type, spleen deficiency and dampness accumulation type and qi and blood deficiency type. The spleen and stomach heat accumulation type should be treated by clearing heat, purging fire, cooling blood and relieving constipation, such as taking traditional Chinese medicine prescriptions such as Qingwei Powder and Yuvie Decoction; the heart fire upward flaming type should be treated by clearing heart and descending fire and cooling blood and diuresis, such as taking traditional Chinese medicine prescriptions such as Chisan and Xiexin Decoction; the liver stagnation and heat accumulation type should be treated by clearing liver and purging fire and regulating qi and cooling blood, such as taking Longchilian Decoction and Xiaochaihu Decoction; the yin deficiency and fire exuberance type should be treated by nourishing yin and clearing heat, such as taking Liuweidihuang Decoction, Qiju Dihuang Decoction and Ganlu Yin; the spleen deficiency and dampness accumulation type should be treated by invigorating the spleen and resolving dampness, such as taking Jianpi Shengshi Decoction, Wuling Powder and Pingwei Powder; and the qi and blood deficiency type should be treated by supplementing qi and blood, such as taking Buzhong Yiqi Decoction and Shenlingbaishu Powder, but the actual clinic is more complicated.

[0003] According to traditional Chinese medicine, the causes of oral ulcer are complex, which are related to low immunity, endocrine function disorder, genetic factors, excessive mental stress and fatigue. If heat-clearing and detoxifying drugs are used, good effects cannot be obtained. Modern medicine mainly relieves symptoms and improves gastric mucosal inflammation, and there is no specific treatment method and drug. SUMMARY

[0004] The application aims to provide a traditional Chinese medicine composition for treating recurrent oral ulcer, a traditional Chinese medicine preparation and a preparation method, which has the effects of supporting healthy qi, promoting tissue regeneration, clearing heat and resolving toxins, and has the advantages of significant curative effect, short treatment course, small toxic and side effects and simple preparation process.

[0005] In order to achieve the above application purposes, the application is implemented by the following technical scheme.

[0006] A traditional Chinese medicine composition for treating recurrent oral ulcer is prepared from the following traditional Chinese medicine materials by weight:

[0007] 15-30 parts of Astragalus, 15-24 parts of stir-fried White Peony Root, 12-18 parts of Raw Rehmannia Glutinosa, 12-18 parts of Honeysuckle, 6-12 parts of Bletilla striata, 6-12 parts of White Ampelopsis, 9-18 parts of Bambusa chinensis, 15-30 parts of Taraxacum mongolicum, and 9-18 parts of Licorice.

[0008] Efficacy: Strengthens the body, promotes tissue regeneration, clears away heat and detoxifies.

[0009] Indications: recurrent oral ulcers that are difficult to heal, pain after eating, dry and bitter mouth, dry and hard stools, etc.

[0010] Recurrent oral ulcers are a type of sore, often caused by fire toxins, located in the mouth and tongue. The mouth is the orifice of the spleen, and the tongue is the sprout of the heart. Therefore, this disease should be treated by focusing on the heart and spleen. Heat accumulation in the heart and spleen can inflame the meridians, transforming fire into toxins, leading to erythema and erosion of the oral mucosa and recurring ulcers. This prescription uses raw Astragalus as the main ingredient, which has the effects of strengthening the spleen and replenishing the middle, expelling toxins and pus, promoting tissue regeneration and healing sores. It is known as the "holy medicine for treating sores." The Yangming meridian is characterized by abundant Qi and blood. Excessive stomach heat can easily affect the blood, leading to prolonged damage to body fluids and Qi, and the generation of internal Yin fire. White peony root is bitter and sour, with a slightly cold nature. It nourishes the blood and harmonizes the vital energy, astringes Yin and calms the liver, and relieves pain. Raw Rehmannia root is sweet and cold, clears heat and nourishes Yin, cools the blood and stops bleeding, and can eliminate "hidden fire in the blood." Together, these two ingredients serve as auxiliary ingredients, nourishing the blood and astringing Yin, counteracting the sweet and warm properties of Astragalus. The heart opens to the tongue and is the exterior and interior of the small intestine. Oral erosions and tongue sores indicate a transfer of heat from the heart to the small intestine, so direct purgation of the heart is not advisable. The auxiliary herbs in the formula, Rehmannia glutinosa, are combined with Dalbergia dasyphylla and Licorice root. The Rehmannia glutinosa in Dao Chi San nourishes the kidneys and cools the heart, Dalbergia dasyphylla clears the internal heat, and Licorice root purges the lowest heat, allowing the heat in the heart meridian to be channeled. The added honeysuckle is pungent and cooling, particularly effective in detoxifying, while dandelion is sweet and cold, purging heat without damaging the earth. Both are effective in eliminating carbuncles and ulcers, cooling the blood and relieving fever, purging heat and calming the upper body. Bletilla striata and Smilax glabra, a common herbal pair used for sores, can clear heat and detoxify, astringe and stop bleeding, and reduce swelling and promote tissue regeneration when applied externally.

[0011] Wound healing is a dynamic and complex process, which needs to go through four typical stages: hemostasis, inflammation, proliferation and tissue remodeling and scar formation. Modern pharmacological studies show that Huangqi can significantly inhibit fibroblast proliferation and angiogenesis and has obvious anti-inflammatory activity, and it can promote the proliferation and differentiation of epidermal stem cells, thereby promoting the growth of granulation tissue, accelerating the process of epithelialization and promoting wound healing. The main effective component in Baishao is total glucosides of Paeonia lactiflora (TGP), which shows good efficacy in the treatment of various immune-related oral diseases including recurrent oral ulcer. Its effects mainly include effectively shortening the healing time of ulcer, improving pain score, promoting the absorption of inflammatory factors, improving immune function, and effectively reducing the recurrence rate during follow-up and prolonging the total interval time to improve long-term efficacy. Shengdihuang has the effects of inhibiting skin fungi, anti-inflammatory, anti-proliferation and exudation, etc. At the same time, the ethanol extract of Shengdihuang has the effect of promoting blood coagulation in anesthetized animals. Honeysuckle has the pharmacological effects of broad-spectrum antibacterial, antiviral, antipyretic, anti-inflammatory and hemostatic. Taraxacum has the effects of broad-spectrum antibacterial, anti-inflammatory, immune regulation, etc. In vitro bacteriostatic test shows that the bacteriostatic effect of the combination of honeysuckle and Taraxacum is significantly stronger than that of single traditional Chinese medicine. In addition, Lophatherum also has the effects of bacteriostasis, antioxidant, vasoconstriction and antiviral. As a commonly used traditional Chinese medicine for wound repair, Baixian can promote cell proliferation, microvessel neogenesis, inhibit scar proliferation and other abilities in each stage of the wound repair process. Bairenwaishengji can not only promote the proliferation of T lymphocytes, the phagocytic function of macrophages, play important roles such as phagocytosis, sterilization, removal of inflammatory products and tissue repair, and indirectly play the anti-infection immune effect by releasing lymphokines, but also can promote the increase of epidermal growth factor in the early and middle stages of wound healing in animal skin, thereby accelerating the healing of the wound. Licorice plays the role of regulating various drugs, and the effective components in licorice, such as quercetin, kaempferol, glycyrrhizal A, naringin and isorhamnetin, can also play a therapeutic role in the treatment of recurrent oral ulcer by eliminating inflammatory reactions and improving microcirculation.

[0012] As a preferred embodiment, the following Chinese medicinal materials are used by weight parts: 30 parts of Huangqi, 24 parts of fried Baishao, 15 parts of Shengdihuang, 15 parts of honeysuckle, 10 parts of Baixian, 10 parts of Bairenwan, 15 parts of Lophatherum, 30 parts of Taraxacum and 15 parts of licorice.

[0013] A traditional Chinese medicine preparation prepared from the traditional Chinese medicine composition for treating recurrent oral ulcer as described above or by adding a pharmaceutically acceptable excipient to the traditional Chinese medicine composition for treating recurrent oral ulcer.

[0014] Preferably, the pharmaceutically acceptable excipients include any one or more combinations of thickeners, humectants, film formers, diluents, disintegrants, lubricants, colorants, sweeteners, binders, antioxidants, dispersants, preservatives, solvents, and coagulants.

[0015] Preferably, the dosage form is any one of mouthwash and mouthwash tablets.

[0016] Preferably, when the dosage form is a mouthwash, the dosage for mouthwash is 5 to 20 mL.

[0017] As a further preferred embodiment, when the dosage form is a mouthwash, the dosage for mouthwash is 10 mL.

[0018] The method for preparing the above-mentioned traditional Chinese medicine composition for treating recurrent oral ulcers comprises the following steps:

[0019] (S.1) Weighing each component of the Chinese medicinal material according to the weight ratio, crushing and sieving to obtain a fine powder;

[0020] (S.2) Evenly mix the fine powder of the drug obtained in step (S.1), add water to decoct, filter the decoction, and concentrate the filtrate to 60°C to obtain a relative density of 1.1 to 1.4 to obtain a concentrated solution.

[0021] Preferably, the method for preparing the above-mentioned Chinese medicine composition for treating recurrent oral ulcers further comprises the following steps:

[0022] (S.3) Adding pharmaceutically acceptable excipients to the concentrated solution obtained in step (S.2) to prepare a mouthwash liquid Chinese medicine preparation.

[0023] Preferably, the method for preparing the above-mentioned Chinese medicine composition for treating recurrent oral ulcers further comprises the following steps:

[0024] (S.3) adding pharmaceutically acceptable excipients to the concentrated solution obtained in step (S.2), and tableting to prepare a mouthwash effervescent tablet.

[0025] Therefore, the present invention has the following beneficial effects:

[0026] (1) The Chinese medicine composition for treating recurrent oral ulcers of the present invention has the effects of strengthening the body, promoting tissue regeneration, clearing away heat and detoxifying, and has a scientific and reasonable formula and a simple preparation process. At the same time, when used as a medicine for treating recurrent oral ulcers, it has the excellent characteristics of significant efficacy, short treatment course, low recurrence after cure, and small toxic and side effects. It can also effectively avoid the adverse reactions caused by the use of Western medicine;

[0027] (2) The traditional Chinese medicine composition for treating recurrent oral ulceration of the present application is accurate and complete in syndrome differentiation, has synergistic effect of each component, treats both symptoms and root causes, has good treatment effect and low recurrence rate, and is helpful for popularization and application in production practice. DETAILED DESCRIPTION

[0028] The present application will be further described below in conjunction with specific examples. Those skilled in the art will be able to implement the present application based on these descriptions. In addition, the embodiments of the present application involved in the following descriptions are generally only embodiments of a part of the present application, rather than all embodiments. Therefore, all other embodiments obtained by those skilled in the art based on the embodiments in the present application without making creative efforts shall belong to the scope of protection of the present application.

[0029] Embodiment 1

[0030] The present embodiment provides a traditional Chinese medicine composition for treating recurrent oral ulceration and a preparation method thereof.

[0031] A traditional Chinese medicine composition for treating recurrent oral ulceration is prepared from the following traditional Chinese medicinal materials by weight parts:

[0032] 30 parts of Huangqi, 24 parts of Chao Baishao, 15 parts of Sheng Dihuang, 15 parts of Jin Yinhua, 10 parts of Baiji, 10 parts of Baiyin, 15 parts of Danzhu Ye, 30 parts of Pugongying, and 15 parts of Gancao.

[0033] A preparation method of a traditional Chinese medicine composition for treating recurrent oral ulceration comprises the following steps:

[0034] (S.1) The traditional Chinese medicinal materials in each component are weighed by weight parts and put into a traditional Chinese medicine pulverizer for pulverization. After pulverization, the fine powder is obtained by passing through a 40-mesh sieve and is reserved for use;

[0035] (S.2) The fine powder obtained in step (S.1) is mixed uniformly and poured into a medicine pot. Water is added for decoction twice. The first time, 10 times the amount of water is added. The decoction is carried out with a strong fire until the decoction liquid boils. Then, the fire is changed to a weak fire for 20-25 min. The decoction liquid is filtered out. The second time, 6 times the amount of water is added. The decoction is carried out with a strong fire until the decoction liquid boils. Then, the fire is changed to a weak fire for 15-20 min. The decoction liquid is filtered out. Then, the decoction liquids of the two times are combined, filtered, and the filter residue is removed to obtain the filtrate. The filtrate is concentrated under reduced pressure to 60℃ to measure the relative density of 1.23 to obtain the concentrated liquid. The concentrated liquid is the traditional Chinese medicine composition for treating recurrent oral ulceration.

[0036] Embodiment 2

[0037] The difference between the present embodiment and Embodiment 1 is that:

[0038] A traditional Chinese medicine composition for treating recurrent oral ulceration is prepared from the following traditional Chinese medicinal materials by weight parts:

[0039] 15 parts of Astragalus, 15 parts of stir-fried White Peony Root, 12 parts of Raw Rehmannia Glutinosa, 12 parts of Honeysuckle, 6 parts of Bletilla striata, 6 parts of Bletilla striata, 9 parts of Bambusa chinensis, 15 parts of Taraxacum mongolicum, and 9 parts of Licorice.

[0040] A method for preparing a traditional Chinese medicine composition for treating recurrent oral ulcers, wherein in step (S.2), the filtrate is concentrated under reduced pressure to 60°C and the relative density is measured to be 1.1. Other aspects are the same as those in Example 1.

[0041] Example 3

[0042] The difference between this embodiment and embodiment 1 is that:

[0043] A traditional Chinese medicine composition for treating recurrent oral ulcers, comprising the following traditional Chinese medicines in parts by weight:

[0044] 25 parts of Astragalus, 19.5 parts of stir-fried White Peony Root, 18 parts of Raw Rehmannia Glutinosa, 18 parts of Honeysuckle, 12 parts of Bletilla striata, 12 parts of White Ampelopsis, 18 parts of Bamboo Leaves, 23 parts of Taraxacum Herba, and 18 parts of Licorice.

[0045] A method for preparing a traditional Chinese medicine composition for treating recurrent oral ulcers, wherein in step (S.2), the filtrate is concentrated under reduced pressure to 60°C, and the relative density is measured to be 1.4. Other aspects are the same as those in Example 1.

[0046] Example 4

[0047] This embodiment provides a Chinese medicine mouthwash liquid preparation for treating recurrent oral ulcers and a preparation method thereof.

[0048] A traditional Chinese medicine preparation for gargling mouth for treating recurrent oral ulcers is prepared from the following Chinese medicinal materials, by weight: 30 parts of astragalus, 24 parts of stir-fried white peony root, 15 parts of raw rehmannia root, 15 parts of honeysuckle, 10 parts of bletilla striata, 10 parts of white ampelopsis, 15 parts of bamboo leaves, 30 parts of dandelion, and 15 parts of liquorice.

[0049] A method for preparing a mouthwash liquid Chinese medicine preparation for treating recurrent oral ulcers comprises the following steps:

[0050] (S.1) Weigh each component of the Chinese medicinal material according to the weight ratio and grind it into a Chinese medicine grinder. After grinding, pass it through a 40-mesh sieve to obtain a fine powder for later use;

[0051] (S.2) Mix the fine powder of the medicine obtained in step (S.1) evenly, pour it into the medicine pot, add water and boil it twice. The first time, add 10 times the amount of water, boil it with high heat until the liquid boils, then switch to low heat and boil it for 20 to 25 minutes, and filter out the decoction; the second time, add 6 times the amount of water, boil it with high heat until the liquid boils, then switch to low heat and boil it for 15 to 20 minutes, and filter out the decoction; then combine the two decoctions, filter and remove the filter residue to obtain a filtrate. Take the filtrate and concentrate it under reduced pressure to 60°C, and the relative density is measured to be 1.23 to obtain a concentrated solution;

[0052] (S.3) Adding pharmaceutically acceptable excipients to the concentrated solution obtained in step (S.2), stirring and mixing uniformly, filtering, diluting to 20 times the amount, sterilizing and bottling, thereby obtaining a Chinese medicine preparation for rinsing mouth (i.e., mouthwash) for treating recurrent oral ulcers.

[0053] Example 5

[0054] This embodiment provides a mouthwash effervescent tablet for treating recurrent oral ulcers and a preparation method thereof.

[0055] A mouthwash effervescent tablet for treating recurrent oral ulcers, prepared from the following Chinese medicinal materials in parts by weight:

[0056] 30 parts of Astragalus, 24 parts of stir-fried White Peony Root, 15 parts of Raw Rehmannia Glutinosa, 15 parts of Flos Lonicerae, 10 parts of Bletilla striata, 10 parts of Bletilla striata, 15 parts of Folium Bambusae, 30 parts of Taraxacum, and 15 parts of Radix Glycyrrhizae.

[0057] A method for preparing a mouthwash effervescent tablet for treating recurrent oral ulcers comprises the following steps:

[0058] (S.1) Weigh each component of the Chinese medicinal material according to the weight ratio and grind it into a Chinese medicine grinder. After grinding, pass it through an 80-mesh sieve to obtain a fine powder for later use;

[0059] (S.2) Mix the fine powder of the medicine obtained in step (S.1) evenly, pour it into the medicine pot, add water and boil it twice. The first time, add 10 times the amount of water, boil it with high heat until the liquid boils, then switch to low heat and boil it for 20 to 25 minutes, and filter out the decoction; the second time, add 6 times the amount of water, boil it with high heat until the liquid boils, then switch to low heat and boil it for 15 to 20 minutes, and filter out the decoction; then combine the two decoctions, filter and remove the filter residue to obtain a filtrate. Take the filtrate and concentrate it under reduced pressure to 60°C, and the relative density is measured to be 1.23 to obtain a concentrated solution;

[0060] (S.3) adding pharmaceutically acceptable excipients to the concentrated solution obtained in step (S.2), and tableting to prepare a mouthwash effervescent tablet.

[0061] Example 6

[0062] The clinical test results of the present invention in treating oral ulcers are as follows:

[0063] General information of experimental subjects: 100 patients with oral ulcers were treated with the Chinese medicine composition of the present invention. The syndrome type belonged to oral ulcers. A total of 100 people participated in the experiment, including 50 males and 50 females. The oldest was 79 years old and the youngest was 18 years old.

[0064] Diagnostic criteria: Participants who meet the following criteria will be selected for the trial:

[0065] Have a history of oral ulcers for more than 1 year; recurrent attacks, at least once a month.

[0066] Symptoms include: initial redness, swelling, pain, thirst, dry stools, fatigue and weakness, recurring mouth ulcers, worse with fatigue, and in the later stages, the surface of the mouth ulcers turns white, the complexion becomes dull, and the pulse is thin.

[0067] Efficacy evaluation criteria: Based on the oral ulcer efficacy evaluation criteria formulated by the Oral Mucosal Disease Committee of the Chinese Stomatological Association.

[0068] Cured: Oral ulcers have not recurred for more than 1 year, and ulcers, pain, edema, and congestion of the throat and oral mucosa have completely disappeared;

[0069] Markedly effective: Ulcers, pain, edema, and congestion of the throat and oral mucosa mostly disappeared within 3 days of medication. The number of ulcers in patients with multiple ulcers decreased significantly, and the interval between ulcer recurrences was significantly prolonged.

[0070] Effective: Ulcers, pain, edema, and congestion of the throat and oral mucosa partially disappear within 6 days. The number of ulcers in patients with multiple ulcers does not decrease significantly, and the interval between ulcer recurrences is prolonged.

[0071] Ineffective: After 6 days, there was no significant change in the patient's ulcer, pain, edema, congestion of the throat and oral mucosa, or the interval between ulcer recurrences. Total effective rate = cure rate + markedly effective rate + effective rate.

[0072] Treatment Method: Usage and Dosage: Use the mouthwash liquid Chinese medicine preparation for treating recurrent oral ulcers prepared in Example 4 of the present invention for gargling. The gargle dosage is 5-20 mL. In this embodiment, the most preferred gargle dosage is 10 mL. Gargle for 3 minutes, 3 times a day, for one week as one course of treatment, for a total of 2 courses of treatment. The statistical results of the efficacy of each group are shown in Table 1 below.

[0073] Table 1

[0074] get well Significantly effective efficient invalid Total efficiency 48 26 24 2 98％ .

[0075] From the data analysis in Table 1, it can be seen that the Chinese medicine composition for treating recurrent oral ulcers and the Chinese medicine preparation for rinsing mouth for treating recurrent oral ulcers of the present invention have the effects of strengthening the body, promoting tissue regeneration, clearing away heat and detoxifying when used, and have significant effects on treating recurrent oral ulcers without causing adverse reactions.

[0076] Typical case 1:

[0077] Chen Moumou, first visit on January 25, 2024:

[0078] Repeated systemic multiple rashes for several years, itching on the back, tingling. Recently based on face, back, ear, once diagnosed and treated in the dermatology department of an external hospital, no obvious improvement. Smooth bowel movements, menstrual flow, easy oral ulcers, dry mouth and eyes from time to time, good appetite, not obvious joint pain, general sleep at night, dreaminess, not obvious fatigue, denies hypertension, diabetes history, denies drug and food allergy history, hair is easily greasy. Pale tongue, dark tongue coating is thin and white, thready pulse. Adopt the mouthwash liquid Chinese medicine preparation for the treatment of recurrent oral ulcer prepared in the embodiment of the present invention 4 to gargle, gargle 3min, 3 times a day, one week is a course for the treatment of, treat 2 courses for the treatment of, oral ulcer, pain, edema, throat and oral mucosal congestion completely disappear, without recurrence.

[0079] Typical Case 2

[0080] Wang, first visit on April 30, 2024:

[0081] After surgery for thyroid malignant tumor, the patient suffered from fatigue, poor appetite, repeated blisters on the tip of the tongue and corners of the mouth, accompanied by pain, cough and sputum, occasionally with blood in the sputum, pale tongue, fat tongue coating, and soft pulse. No abnormalities were found in liver and kidney function. The Chinese medicine preparation for treating recurrent oral ulcers prepared in Example 4 of the present invention was used for gargling. The gargling dosage was 5 to 20 mL. In this embodiment, the most preferred gargling dosage was 10 mL. Gargling was performed for 3 minutes, 3 times a day, for a course of one week.

[0082] Follow-up visit on May 5, 2024:

[0083] Fatigue and poor appetite have improved, blisters on the tip of the tongue and corners of the mouth have subsided, coughing and sputum have decreased, and there are no obvious blood streaks or blood clots. The tongue is pale, plump, and has a smooth coating. The pulse is weak and soft. Liver and kidney function are normal. Oral ulcers, pain, edema, and congestion in the throat and oral mucosa have completely disappeared and have not recurred.

[0084] The above description is only a detailed description of the preferred embodiments and principles of the present invention. For ordinary technicians in this field, based on the ideas provided by the present invention, there may be changes in the specific implementation methods, and these changes should also be considered as the scope of protection of the present invention.

Claims

1. A Chinese medicinal composition for external use for treating recurrent oral ulcers, characterized in that: By weight, it is made from the following Chinese medicinal materials: 15-30 parts of Astragalus, 15-24 parts of stir-fried White Peony Root, 12-18 parts of Raw Rehmannia Glutinosa, 12-18 parts of Honeysuckle, 6-12 parts of Bletilla striata, 6-12 parts of White Ampelopsis, 9-18 parts of Bamboo Leaves, 15-30 parts of Taraxacum, and 9-18 parts of Licorice.

2. A Chinese medicinal composition for external use for treating recurrent oral ulcers according to claim 1, characterized in that: The invention is prepared from the following Chinese medicinal materials by weight: 30 parts of astragalus, 24 parts of stir-fried white peony root, 15 parts of raw rehmannia root, 15 parts of honeysuckle, 10 parts of white striata, 10 parts of white ampelopsis, 15 parts of bamboo leaves, 30 parts of dandelion, and 15 parts of liquorice.

3. A Chinese medicine preparation prepared by adding pharmaceutically acceptable excipients to the external Chinese medicine composition for treating recurrent oral ulcers according to claim 1 or 2.

4. A Chinese medicine preparation for treating recurrent oral ulcers according to claim 3, characterized in that, Pharmaceutically acceptable excipients are any one or more of thickeners, humectants, film formers, diluents, disintegrants, lubricants, colorants, sweeteners, binders, antioxidants, dispersants, preservatives, solvents, and coagulants.

5. A Chinese medicine preparation for treating recurrent oral ulcers according to claim 3, characterized in that, The Chinese medicine preparation is a mouthwash.

6. A method for preparing a traditional Chinese medicine composition for external use for treating recurrent oral ulcers according to claim 1 or 2, characterized in that: The following steps are involved: (S.1) Weigh each component of the Chinese medicinal material according to the weight ratio, crush it, and sieve it to obtain a fine powder; (S.2) Evenly mix the fine powder of the drug obtained in step (S.1), add water to decoct, filter the decoction, and concentrate the filtrate to 60°C and measure the relative density to be 1.1-1.4 to obtain a concentrated solution.

7. The method for preparing a traditional Chinese medicine composition for external use for treating recurrent oral ulcers according to claim 6, characterized in that: The following steps are also included: (S.3) Adding pharmaceutically acceptable excipients to the concentrated solution obtained in step (S.2) to prepare a mouthwash.