Gynecological bacteriostatic nursing gel containing hydrolyzed collagen and preparation method thereof

Abstract

The invention discloses a gynecological antibacterial nursing gel containing hydrolyzed collagen and a preparation method thereof. Comprising the following raw materials in parts by weight: 4 to 12 parts of hydrolyzed collagen, 1 to 3 parts of glutathione, 2 to 4 parts of sophocarpidine, 0.2 to 0.5 part of resveratrol, 1 to 3 parts of hydroxybutyl chitosan, 15 to 20 parts of a traditional Chinese medicine extract, 0.5 to 1.5 parts of sodium hyaluronate, 0.1 to 0.25 part of plant essential oil, 1 to 3 parts of triethanolamine, 0.8 to 1.5 parts of lactic acid, 1 to 2 parts of carboxymethylcellulose, 1 to 1.5 parts of glycerol, 1 to 2 parts of carbomer and 0.5 to 1.5 parts of an emulsifier, 1-3 parts of a pH regulator, 10-15 parts of an irradiation improver, and the balance of purified water, totaling 100 parts; the invention relates to the technical field of gynecological gel. According to the gynecological antibacterial nursing gel containing the hydrolyzed collagen and the preparation method, the antibacterial effect of the gel is enhanced by adding the hydrolyzed collagen, so that the antibacterial effect is more durable, and the hydrolyzed collagen has relatively small molecular weight, is easily absorbed by skin, and can quickly permeate into vaginal mucosa to play nourishing and repairing roles.

Description

Technical Field

[0001] The present invention relates to the technical field of gynecological gels, and specifically to a gynecological antibacterial and nursing gel containing hydrolyzed collagen and a preparation method thereof. Background Art

[0002] Female reproductive system diseases are gynecological diseases. Gynecological diseases have a wide range, including vulvar diseases, vaginal diseases, uterine diseases, fallopian tube diseases, ovarian diseases, etc. Gynecological diseases are common and frequently-occurring diseases in women. The main symptoms include increased vaginal discharge, vulvar pruritus. Acute adnexitis is also accompanied by symptoms such as abdominal pain and fever, and chronic adnexitis is accompanied by symptoms such as abdominal pain and increased leucorrhea. Antibacterial gels are used in the treatment of such gynecological diseases.

[0003] Refer to the patent publication number "CN115645510A", which discloses a gynecological antibacterial and nursing gel containing hydrolyzed collagen and a preparation method thereof. Specifically, it includes the following components in parts by weight: 0.1 - 0.9 part of fructus cnidii extract, 0.1 - 0.9 part of sophora flavescens extract, 0.1 - 0.9 part of lotus leaf extract, 0.1 - 0.9 part of tea extract, 0.1 - 0.9 part of guava leaf extract, 0.1 - 0.9 part of angelica extract, 3 - 10 parts of hydrolyzed collagen, 5 - 11 parts of hydroxyethyl cellulose, 0.03 - 0.18 part of benzalkonium chloride, and 85 - 95 parts of purified water.

[0004] As shown in the above technology, the existing gynecological antibacterial gels on the market generally have problems such as non - persistent antibacterial effect, easy generation of side effects, or poor absorption effect. Therefore, it is of great significance to develop a gynecological antibacterial and nursing gel with a persistent antibacterial effect, no toxic side effects, easy absorption, and effective vaginal nourishment. Summary of the Invention

[0005] Aiming at the deficiencies of the prior art, the present invention provides a gynecological antibacterial and nursing gel containing hydrolyzed collagen and a preparation method thereof, which solves the problem of the non - persistent antibacterial effect of the existing gynecological antibacterial and nursing gels.

[0006] To achieve the above objectives, the present invention is realized through the following technical solutions: A gynecological antibacterial and nursing gel containing hydrolyzed collagen, comprising the following raw materials in parts by weight:

[0007] 4 - 12 parts of hydrolyzed collagen, 1 - 3 parts of glutathione, 2 - 4 parts of matrine, 0.2 - 0.5 of resveratrol, 1 - 3 parts of hydroxybutyl chitosan, 15 - 20 parts of traditional Chinese medicine extract, 0.5 - 1.5 parts of sodium hyaluronate, 0.1 - 0.25 parts of plant essential oil, 1 - 3 parts of triethanolamine, 0.8 - 1.5 parts of lactic acid, 1 - 2 parts of carboxymethyl cellulose, 1 - 1.5 parts of glycerol, 1 - 2 parts of carbomer, 0.5 - 1.5 parts of emulsifier, 1 - 3 parts of pH regulator, 10 - 15 parts of irradiation improver, and purified water to make up 100 parts;

[0008] The traditional Chinese medicine extract is made from the following raw materials by weight: 8 - 10 parts of sophora flavescens, 6 - 8 parts of phellodendron amurense, 2 - 4 parts of cnidium monnieri, 4 - 6 parts of salvia miltiorrhiza, 4 - 6 parts of carthamus tinctorius, 2 - 5 parts of roasted licorice root, 1 - 3 parts of guava leaves, and 7 - 10 parts of motherwort.

[0009] Preferably, it includes the following raw materials by weight:

[0010] 4 parts of hydrolyzed collagen, 1 part of glutathione, 2 parts of matrine, 0.2 of resveratrol, 1 part of hydroxybutyl chitosan, 15 parts of traditional Chinese medicine extract, 0.5 parts of sodium hyaluronate, 0.1 parts of plant essential oil, 1 part of triethanolamine, 0.8 parts of lactic acid, 1 part of carboxymethyl cellulose, 1 part of glycerol, 1 part of carbomer, 0.5 parts of emulsifier, 1 part of pH regulator, 10 parts of irradiation improver, and purified water to make up 100 parts;

[0011] The traditional Chinese medicine extract is made from the following raw materials by weight: 8 parts of sophora flavescens, 6 parts of phellodendron amurense, 2 parts of cnidium monnieri, 4 parts of salvia miltiorrhiza, 4 parts of carthamus tinctorius, 2 parts of roasted licorice root, 1 part of guava leaves, and 7 parts of motherwort.

[0012] Preferably, it includes the following raw materials by weight:

[0013] 8 parts of hydrolyzed collagen, 2 parts of glutathione, 3 parts of matrine, 0.35 of resveratrol, 2 parts of hydroxybutyl chitosan, 18 parts of traditional Chinese medicine extract, 1 part of sodium hyaluronate, 0.2 parts of plant essential oil, 2 parts of triethanolamine, 1.2 parts of lactic acid, 1.5 parts of carboxymethyl cellulose, 1.25 parts of glycerol, 1.5 parts of carbomer, 1 part of emulsifier, 2 parts of pH regulator, 13 parts of irradiation improver, and purified water to make up 100 parts;

[0014] The traditional Chinese medicine extract is made from the following raw materials by weight: 9 parts of sophora flavescens, 7 parts of phellodendron amurense, 3 parts of cnidium monnieri, 5 parts of salvia miltiorrhiza, 5 parts of carthamus tinctorius, 3.5 parts of roasted licorice root, 2 parts of guava leaves, and 8.5 parts of motherwort.

[0015] Preferably, it includes the following raw materials by weight:

[0016] 12 parts of hydrolyzed collagen, 3 parts of glutathione, 4 parts of matrine, 0.5 parts of resveratrol, 3 parts of hydroxybutyl chitosan, 20 parts of traditional Chinese medicine extract, 1.5 parts of sodium hyaluronate, 0.25 parts of plant essential oil, 3 parts of triethanolamine, 1.5 parts of lactic acid, 2 parts of carboxymethyl cellulose, 1.5 parts of glycerol, 2 parts of carbomer, 1.5 parts of emulsifier, 3 parts of pH regulator, 15 parts of irradiation improver, and purified water to make up 100 parts;

[0017] The traditional Chinese medicine extract is made from the following raw materials in parts by weight: 10 parts of Sophora flavescens, 8 parts of Phellodendron amurense, 4 parts of Cnidium monnieri, 6 parts of Salvia miltiorrhiza, 6 parts of Carthamus tinctorius, 5 parts of roasted licorice, 3 parts of Psidium guajava leaves, and 10 parts of Leonurus japonicus.

[0018] Preferably, the hydrolyzed collagen is prepared from fish skin as the raw material.

[0019] Preferably, the irradiation improver is usually mannitol.

[0020] The present invention also discloses a preparation method of a gynecological antibacterial nursing gel containing hydrolyzed collagen, which specifically includes the following steps:

[0021] Step 1: Use fish skin as the raw material, wash, degrease and chop it, then soak it in sodium hydroxide solution, take it out and wash it, add the treated raw material to an appropriate amount of water, adjust the pH value, add alkaline protease, and carry out an enzymatic hydrolysis reaction at a suitable temperature. The enzymatic hydrolysis time is generally 1-10 hours. Inactivate the enzyme and filter: After the enzymatic hydrolysis is completed, carry out an enzyme inactivation treatment, then filter to obtain the filtrate. The filtrate is concentrated and dried to obtain hydrolyzed collagen, and it is reserved for use;

[0022] Step 2: Place Sophora flavescens, Phellodendron amurense, Cnidium monnieri, Salvia miltiorrhiza, Carthamus tinctorius, roasted licorice, Psidium guajava leaves, Angelica sinensis and Leonurus japonicus into a washing machine for washing, and place the washed medicine on a shelf for natural air drying. After air drying, cut them separately, and mix the sliced raw materials with an appropriate amount of extractant in a specified ratio, put them into an extraction device for extraction, and then obtain the corresponding preliminary extract. After concentration and drying, obtain the traditional Chinese medicine extract, and reserve it for use;

[0023] Step 2: Weigh the corresponding extracts of Cnidium monnieri, Sophora flavescens, roasted licorice, tea extract, Psidium guajava leaves, Angelica sinensis extract and purified water according to the parts by weight, and mix and stir them evenly to obtain the first mixed solution;

[0024] Step 3: Add the corresponding parts by weight of glutathione, matrine, resveratrol, hydroxybutyl chitosan, plant essential oil, triethanolamine, lactic acid and carboxymethyl cellulose, and continue to stir evenly to obtain the first mixed solution;

[0025] Step 4: Add glycerol, carbomer, emulsifier, pH regulator, irradiation improver and hydrolyzed collagen, and continue to stir evenly. Then evacuate to obtain the gynecological antibacterial care gel containing hydrolyzed collagen.

[0026] Step 5: Fill the prepared gynecological antibacterial care gel containing hydrolyzed collagen with a fully automatic gel filling machine.

[0027] Preferably, when stirring and mixing in Step 4, control the stirring temperature at 60°C - 80°C.

[0028] The present invention provides a gynecological antibacterial care gel containing hydrolyzed collagen and a preparation method. Compared with the prior art, it has the following beneficial effects:

[0029] 1. For the gynecological antibacterial care gel containing hydrolyzed collagen and its preparation method, the addition of hydrolyzed collagen enhances the antibacterial effect of the gel, making the antibacterial effect more persistent. Hydrolyzed collagen has a small molecular weight and is easily absorbed by the skin. It can quickly penetrate into the vaginal mucosa to play a nourishing and repairing role. Hydrolyzed collagen contains various amino acids, which are important raw materials for synthesizing its own collagen. It can nourish the vaginal mucosa, promote vaginal health, and cooperate with glutathione to enhance the effect of hydrolyzed collagen.

[0030] 2. For the gynecological antibacterial care gel containing hydrolyzed collagen and its preparation method, the traditional Chinese medicine extract has a more extensive antibacterial effect and can effectively inhibit the growth of various bacteria and viruses, further enhancing the persistence of the antibacterial effect. All components are natural extracts or biodegradable materials, which have no toxic and side effects on the human body and are safe to use.

[0031] 3. For the gynecological antibacterial care gel containing hydrolyzed collagen and its preparation method, irradiation improvers are used to significantly improve the adverse effects of irradiation on carbomer and collagen. They can ensure the biological activity of collagen, so that the gel viscosity does not decrease or even increases after irradiation, which is conducive to the targeted coating of the gel and improves the moisturizing and repairing effect. Description of the Drawings

[0032] Figure 1 It is a flowchart of the preparation method of the present invention. Detailed Embodiments

[0033] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0034] The gynecological antibacterial care gel containing hydrolyzed collagen provides three technical solutions:

[0035] It includes raw materials in the following parts by weight:

[0036] 4 - 12 parts of hydrolyzed collagen, 1 - 3 parts of glutathione, 2 - 4 parts of matrine, 0.2 - 0.5 of resveratrol, 1 - 3 parts of hydroxybutyl chitosan, 15 - 20 parts of traditional Chinese medicine extract, 0.5 - 1.5 parts of sodium hyaluronate, 0.1 - 0.25 parts of plant essential oil, 1 - 3 parts of triethanolamine, 0.8 - 1.5 parts of lactic acid, 1 - 2 parts of carboxymethyl cellulose, 1 - 1.5 parts of glycerol, 1 - 2 parts of carbomer, 0.5 - 1.5 parts of emulsifier, 1 - 3 parts of pH regulator, 10 - 15 parts of irradiation improver, and purified water is added to make up 100 parts;

[0037] The traditional Chinese medicine extract is composed of raw materials in the following parts by weight: 8 - 10 parts of sophora flavescens, 6 - 8 parts of phellodendron amurense, 2 - 4 parts of fructus cnidii, 4 - 6 parts of salvia miltiorrhiza, 4 - 6 parts of carthamus tinctorius, 2 - 5 parts of roasted licorice root, 1 - 3 parts of guava leaves, and 7 - 10 parts of motherwort.

[0038] The hydrolyzed collagen is prepared from fish skin as raw material, and mannitol is usually selected as the irradiation improver.

[0039] Example 1: 4 parts of hydrolyzed collagen, 1 part of glutathione, 2 parts of matrine, 0.2 of resveratrol, 1 part of hydroxybutyl chitosan, 15 parts of traditional Chinese medicine extract, 0.5 part of sodium hyaluronate, 0.1 part of plant essential oil, 1 part of triethanolamine, 0.8 part of lactic acid, 1 part of carboxymethyl cellulose, 1 part of glycerol, 1 part of carbomer, 0.5 part of emulsifier, 1 part of pH regulator, 10 parts of irradiation improver, and purified water is added to make up 100 parts;

[0040] The traditional Chinese medicine extract is composed of raw materials in the following parts by weight: 8 parts of sophora flavescens, 6 parts of phellodendron amurense, 2 parts of fructus cnidii, 4 parts of salvia miltiorrhiza, 4 parts of carthamus tinctorius, 2 parts of roasted licorice root, 1 part of guava leaves, and 7 parts of motherwort.

[0041] The gynecological antibacterial care gel containing hydrolyzed collagen is prepared through the following steps:

[0042] Step 1: Take fish skin as raw material, wash, degrease, chop it, soak it in sodium hydroxide solution, take it out, wash it, add the treated raw material to an appropriate amount of water, adjust the pH value, add alkaline protease, and carry out enzymatic hydrolysis reaction at a suitable temperature. The enzymatic hydrolysis time is generally 1 - 10 hours. Inactivate the enzyme and filter: After the enzymatic hydrolysis is completed, carry out enzyme inactivation treatment, then filter to obtain the filtrate. The filtrate is concentrated and dried to obtain hydrolyzed collagen and reserve it;

[0043] Step 2: Place Sophora flavescens, Phellodendron amurense, Cnidium monnieri, Salvia miltiorrhiza, Carthamus tinctorius, Honey-fried Licorice Root, Psidium guajava leaves, Angelica sinensis and Leonurus japonicus in a washing machine for cleaning, and place the cleaned drugs on a shelf for natural air drying. After air drying, slice them separately, and mix the sliced raw materials with an appropriate amount of extractant in a specified ratio, and put them into an extraction device for extraction to obtain the corresponding preliminary extract. After concentration and drying, a traditional Chinese medicine extract is obtained and reserved;

[0044] Step 2: Weigh the corresponding Cnidium monnieri extract, Sophora flavescens extract, Honey-fried Licorice Root extract, tea extract, Psidium guajava leaf extract, Angelica sinensis extract and purified water according to the weight parts respectively, and mix and stir them evenly to obtain the first mixed solution;

[0045] Step 3: Add the corresponding weight parts of glutathione, matrine, resveratrol, hydroxybutyl chitosan, plant essential oil, triethanolamine, lactic acid and carboxymethyl cellulose, and continue to stir evenly to obtain the second mixed solution;

[0046] Step 4: Add glycerol, carbomer, emulsifier, PH regulator and hydrolyzed collagen, and continue to stir evenly. After vacuum pumping, a gynecological antibacterial nursing gel containing hydrolyzed collagen is obtained;

[0047] Step 5: Fill the prepared gynecological antibacterial nursing gel containing hydrolyzed collagen with a fully automatic gel filling machine.

[0048] Example 2:

[0049] 8 parts of hydrolyzed collagen, 2 parts of glutathione, 3 parts of matrine, 0.35 of resveratrol, 2 parts of hydroxybutyl chitosan, 18 parts of traditional Chinese medicine extract, 1 part of sodium hyaluronate, 0.2 part of plant essential oil, 2 parts of triethanolamine, 1.2 parts of lactic acid, 1.5 parts of carboxymethyl cellulose, 1.25 parts of glycerol, 1.5 parts of carbomer, 1 part of emulsifier, 2 parts of PH regulator, 13 parts of irradiation improver and purified water to make up 100 parts;

[0050] The traditional Chinese medicine extract is made from the following raw materials in weight parts: 9 parts of Sophora flavescens, 7 parts of Phellodendron amurense, 3 parts of Cnidium monnieri, 5 parts of Salvia miltiorrhiza, 5 parts of Carthamus tinctorius, 3.5 parts of Honey-fried Licorice Root, 2 parts of Psidium guajava leaves and 8.5 parts of Leonurus japonicus.

[0051] Example 3:

[0052] 12 parts of hydrolyzed collagen, 3 parts of glutathione, 4 parts of matrine, 0.5 of resveratrol, 3 parts of hydroxybutyl chitosan, 20 parts of traditional Chinese medicine extract, 1.5 parts of sodium hyaluronate, 0.25 part of plant essential oil, 3 parts of triethanolamine, 1.5 parts of lactic acid, 2 parts of carboxymethyl cellulose, 1.5 parts of glycerol, 2 parts of carbomer, 1.5 parts of emulsifier, 3 parts of PH regulator, 15 parts of irradiation improver and purified water to make up 100 parts;

[0053] The traditional Chinese medicine extract is made from raw materials in the following parts by weight: 10 parts of Sophora flavescens, 8 parts of Phellodendron amurense, 4 parts of Cnidium monnieri, 6 parts of Salvia miltiorrhiza, 6 parts of Carthamus tinctorius, 5 parts of roasted licorice, 3 parts of Psidium guajava leaves, and 10 parts of Leonurus japonicus.

[0054] Original formula:

[0055] 6 parts of benzalkonium chloride, 18 parts of traditional Chinese medicine extract, 1 part of sodium hyaluronate, 0.2 part of plant essential oil, 2 parts of triethanolamine, 1.2 parts of lactic acid, 1.5 parts of carboxymethyl cellulose, 1.25 parts of glycerol, 1.5 parts of carbomer, 1 part of emulsifier, 2 parts of pH regulator, and purified water to make up 100 parts;

[0056] The traditional Chinese medicine extract is made from raw materials in the following parts by weight: 9 parts of Sophora flavescens, 7 parts of Phellodendron amurense, 3 parts of Cnidium monnieri, 5 parts of Salvia miltiorrhiza, and 5 parts of Carthamus tinctorius.

[0057] Drug treatment effect experiment:

[0058] Three test strains are used for the test, including Staphylococcus aureus, Escherichia coli, and Candida albicans. The test is divided into four groups, namely Example 1, Example 2, Example 3, and the original formula. Among them, the substances with the same raw materials in the original formula and Example 2 maintain the same parts by weight, and the bacteriostatic rate is measured at 2 min, 5 min, 10 min, and 20 min of the test time.

[0059]

[0060]

[0061] It can be seen from the tests in the above table that the gynecological bacteriostatic nursing gel containing hydrolyzed collagen provided by the present invention has excellent therapeutic ability, and the gynecological bacteriostatic nursing gel containing hydrolyzed collagen can still maintain excellent bacteriostatic ability with the increase of the action time. Among them, the weight components in Example 2 are the most excellent and are significantly better than the original formula.

[0062] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "including", "comprising" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device.

[0063] Although embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A gynecological antibacterial nursing gel containing hydrolyzed collagen and a preparation method thereof, characterized in that: Comprising the following raw materials in parts by weight: Hydrolyzed collagen 4 - 12 parts, glutathione 1 - 3 parts, matrine 2 - 4 parts, resveratrol 0.2 - 0.5, hydroxybutyl chitosan 1 - 3 parts, Chinese herbal medicine extract 15 - 20 parts, sodium hyaluronate 0.5 - 1.5 parts, plant essential oil 0.1 - 0.25 parts, triethanolamine 1 - 3 parts, lactic acid 0.8 - 1.5 parts, carboxymethyl cellulose 1 - 2 parts, glycerol 1 - 1.5 parts, carbomer 1 - 2 parts, emulsifier 0.5 - 1.5 parts, pH regulator 1 - 3 parts, irradiation improver 10 - 15 parts, and purified water to make up 100 parts; The Chinese herbal medicine extract is composed of the following raw materials in parts by weight: sophora flavescens 8 - 10 parts, phellodendron amurense 6 - 8 parts, fructus cnidii 2 - 4 parts, salvia miltiorrhiza 4 - 6 parts, carthamus tinctorius 4 - 6 parts, roasted licorice root 2 - 5 parts, psidium guajava leaves 1 - 3 parts, and motherwort 7 - 10 parts.

2. A gynecological antibacterial care gel containing hydrolyzed collagen and a preparation method thereof according to claim 1, characterized in that: Comprising the following raw materials in parts by weight: Hydrolyzed collagen 4 parts, glutathione 1 part, matrine 2 parts, resveratrol 0.2, hydroxybutyl chitosan 1 part, Chinese herbal medicine extract 15 parts, sodium hyaluronate 0.5 part, plant essential oil 0.1 part, triethanolamine 1 part, lactic acid 0.8 part, carboxymethyl cellulose 1 part, glycerol 1 part, carbomer 1 part, emulsifier 0.5 part, pH regulator 1 part, irradiation improver 10 parts, and purified water to make up 100 parts; The Chinese herbal medicine extract is composed of the following raw materials in parts by weight: sophora flavescens 8 parts, phellodendron amurense 6 parts, fructus cnidii 2 parts, salvia miltiorrhiza 4 parts, carthamus tinctorius 4 parts, roasted licorice root 2 parts, psidium guajava leaves 1 part, and motherwort 7 parts.

3. A gynecological antibacterial care gel containing hydrolyzed collagen and a preparation method thereof according to claim 1, characterized in that: Comprising the following raw materials in parts by weight: Hydrolyzed collagen 8 parts, glutathione 2 parts, matrine 3 parts, resveratrol 0.35, hydroxybutyl chitosan 2 parts, Chinese herbal medicine extract 18 parts, sodium hyaluronate 1 part, plant essential oil 0.2 part, triethanolamine 2 parts, lactic acid 1.2 parts, carboxymethyl cellulose 1.5 parts, glycerol 1.25 parts, carbomer 1.5 parts, emulsifier 1 part, pH regulator 2 parts, irradiation improver 13 parts, and purified water to make up 100 parts; The Chinese herbal medicine extract is composed of the following raw materials in parts by weight: sophora flavescens 9 parts, phellodendron amurense 7 parts, fructus cnidii 3 parts, salvia miltiorrhiza 5 parts, carthamus tinctorius 5 parts, roasted licorice root 3.5 parts, psidium guajava leaves 2 parts, and motherwort 8.5 parts.

4. A gynecological antibacterial care gel containing hydrolyzed collagen and a preparation method thereof according to claim 1, characterized in that: Comprising the following raw materials in parts by weight: Hydrolyzed collagen 12 parts, glutathione 3 parts, matrine 4 parts, resveratrol 0.5, hydroxybutyl chitosan 3 parts, Chinese herbal medicine extract 20 parts, sodium hyaluronate 1.5 parts, plant essential oil 0.25 part, triethanolamine 3 parts, lactic acid 1.5 parts, carboxymethyl cellulose 2 parts, glycerol 1.5 parts, carbomer 2 parts, emulsifier 1.5 parts, pH regulator 3 parts, irradiation improver 15 parts, and purified water to make up 100 parts; The Chinese herbal medicine extract is composed of the following raw materials in parts by weight: sophora flavescens 10 parts, phellodendron amurense 8 parts, fructus cnidii 4 parts, salvia miltiorrhiza 6 parts, carthamus tinctorius 6 parts, roasted licorice root 5 parts, psidium guajava leaves 3 parts, and motherwort 10 parts.

5. A gynecological antibacterial nursing gel containing hydrolyzed collagen and a preparation method thereof according to claim 1, characterized in that: The hydrolyzed collagen is prepared from fish skin as the raw material.

6. The gynecological antibacterial nursing gel containing hydrolyzed collagen and its preparation method according to claim 1, characterized in that: The irradiation improver is usually mannitol.

7. A preparation method of a gynecological antibacterial nursing gel containing hydrolyzed collagen, characterized in that: Comprising the following steps: Step 1: Use fish skin as raw material, wash, degrease, chop it, soak it in sodium hydroxide solution, take it out, wash it, add the treated raw material to an appropriate amount of water, adjust the pH value, add alkaline protease, and carry out enzymatic hydrolysis reaction at an appropriate temperature. The enzymatic hydrolysis time is generally 1 - 10 hours. Inactivate the enzyme and filter: After enzymatic hydrolysis is completed, carry out enzyme inactivation treatment, then filter to obtain the filtrate. The filtrate is concentrated and dried to obtain hydrolyzed collagen, which is reserved for use; Step 2: Place Sophora flavescens, Phellodendron amurense, Cnidium monnieri, Salvia miltiorrhiza, Carthamus tinctorius, Radix Glycyrrhizae Preparata, Psidium guajava leaves, Angelica sinensis and Leonurus japonicus in a washing machine for washing, and place the washed drugs on a shelf for natural air drying. After air drying, cut them separately, and mix the sliced raw materials with an appropriate amount of extractant in a specified ratio, put them into an extraction device for extraction, and then obtain the corresponding preliminary extract. After concentration and drying, obtain the traditional Chinese medicine extract, which is reserved for use; Step 2: Weigh the corresponding extracts of Cnidium monnieri, Sophora flavescens, Radix Glycyrrhizae Preparata, tea extract, Psidium guajava leaf extract, Angelica sinensis extract and purified water according to parts by weight, and mix and stir evenly to obtain the first mixed solution; Step 3: Add the corresponding parts by weight of glutathione, matrine, resveratrol, hydroxybutyl chitosan, plant essential oil, triethanolamine, lactic acid and carboxymethyl cellulose, and continue to stir evenly to obtain the first mixed solution; Step 4: Add glycerol, carbomer, emulsifier, pH regulator, irradiation improver and hydrolyzed collagen, and continue to stir evenly. After evacuating the air, obtain the gynecological antibacterial nursing gel containing hydrolyzed collagen; Step 5: Fill the prepared gynecological antibacterial nursing gel containing hydrolyzed collagen with a fully automatic gel filling machine.

8. The preparation method of a gynecological antibacterial nursing gel containing hydrolyzed collagen according to claim 1, characterized in that: When stirring and mixing in Step 4, control the stirring temperature at 60°C - 80°C.

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